DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA and Stag3

DIOPT Version :9

Sequence 1:	NP_477268.2	Gene:	SA / 33974	FlyBaseID:	FBgn0020616	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	NP_446182.1	Gene:	Stag3 / 114522	RGDID:	621333	Length:	1256	Species:	Rattus norvegicus

Alignment Length:	1087	Identity:	426/1087 - (39%)
Similarity:	660/1087 - (60%)	Gaps:	68/1087 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DDDEDDFFAPIARKRKTPATRKGPTERKERVERPRKEP--VDKGHHERIDSEREI--TTDENSLY 118
            |.|.:|......|||    ..|.|.:.....:.|:|:.  |..|:    |..:.:  |:|   |:
  Rat    63 DSDFEDSLRRNVRKR----AAKRPPKAIPVAKHPKKQSHIVPGGN----DKNKSVPPTSD---LF 116

  Fly   119 YIVRHSKNPIASIVDQWIEQYKANRETALVALMQFFINASGCKGKISEDIQYPVDHTSIIRRMTE 183
            ..|:.:::...|:||:|:|.||.:.....:.|:.|||.|.|||..::.::...:.::.||:.:||
  Rat   117 DAVKAARSCAQSLVDEWLENYKQDENAGFLELVNFFIRACGCKSTVTPEMFKTMSNSEIIQHLTE 181

  Fly   184 EFDEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQCQYSIIYDQFLMDNVISLLTGLSDSQVRAF 248
            ||:|:||:|||...|..|:||:.:||:||:|||.|||||:::|.|.||::||||.||||||||||
  Rat   182 EFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVCQCQYSLLFDGFPMDDLISLLIGLSDSQVRAF 246

  Fly   249 RHTATLAAMKLMTALVDVALLVSNNFDNAAKQFEAERVKSRDRRASDRLDSLMTKRSELEENMDE 313
            |||:|||||||||:||.|||.:|.:.||..:|:||||.|..::||.:||:||:.||.|.:||.:|
  Rat   247 RHTSTLAAMKLMTSLVKVALQLSLHKDNNQRQYEAERNKGPEQRAPERLESLLEKRKEFQENQEE 311

  Fly   314 IKSMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWMENYPQNFLDDSYLKYIGWTLHDKIGEVRL 378
            |:.|:..:|:.||||||||.||:|||:|:.|||.||::|..:||:||||||||||||||..||||
  Rat   312 IEGMMNAIFRGVFVHRYRDILPEIRAVCIEEIGCWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRL 376

  Fly   379 RCLQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLDKEFEVSVHAVKLVISILKIHPEILADKDC 443
            :|:::|..||...||..::||||::||||:|:|.:|:|.||:|.|::|:..|||....:|...||
  Rat   377 KCVKALAGLYSNQELSSRMELFTNRFKDRMVSMVMDRESEVAVEAIRLLTLILKNMEGVLTSADC 441

  Fly   444 EIVYELVYSSHRGVAQAAAEFLNVRLFHLTADMEETKTKRGKVRMPNTPLVRD----LVQFFIES 504
            |.:|.:||.|:|.:|.:|.||:..::||....   .|...|:.|..:....|.    |:.||:||
  Rat   442 EKIYSIVYISNRAMASSAGEFVYWKIFHPECG---AKAVSGRERRRSPQAQRTFIYLLLAFFMES 503

  Fly   505 ELHEHGAYLVDSFID-SNDMVRDWECMTDLLLEEPGPNEEVLDNKQESTLIEIMVSSVKQSATGE 568
            |.|:|.||||||..| :...::|||.:|.|||::    ::.|.:.||..||||:|||.:|:|.|.
  Rat   504 EHHDHAAYLVDSLWDCAGSYLKDWESLTSLLLQK----DQNLGDMQERMLIEILVSSARQAAEGH 564

  Fly   569 VPVGRASNRKCTLSAKELKAIQDEKAKLTEHFIVTLPSLLEKYQADSEKLANLLAVPQYFDLNLY 633
            .||||.:.:| :|:|||.|....:|.||.||.|..||.||.|:.||:|.:|.||.:..|||||:|
  Rat   565 PPVGRITGKK-SLTAKERKLQAYDKVKLAEHLIPLLPQLLAKFSADAENVAPLLRLLSYFDLNIY 628

  Fly   634 TTNRQEGNLQALLDRINQVMSMHTGREVLETCAKTLECLCAEGSATYTRCNIARSNIIESAVNKY 698
            .|.|.|.:|:.||.::.:|:..|...||||..|..|..||......::|.:.|||.:::...:::
  Rat   629 CTQRLEKHLELLLQQLQEVVVKHVEPEVLEAAAHALYLLCKPEFTFFSRVDFARSQLVDLLTDRF 693

  Fly   699 KDAIEEWRNLIQGEETPNEDDIYNITITLKVLSILYSSHNLNPWELFKSLFQDVEEAQSKENIDR 763
            :..:::   |:|.... :||::|::|.|||.||..|::|:|..||:.:...:.:.:|.....:
  Rat   694 QQELDD---LMQSSFL-DEDEVYSLTATLKRLSAFYNAHDLTRWEISEPCSRLLRKAVDTGEV-- 752

  Fly   764 CLPNEALVYCIEACYFSISWGLQYVENECESVNVTEVVAELRNNLDTFMGACFELTRD-GPTVQI 827
              |::.::..:...||||.|.:.::.   ||.:..:::: |:..:..|...|.....| .|  :|
  Rat   753 --PHQVILPALTLVYFSILWTVTHIS---ESTSQKQLMS-LKKRMVAFCELCQSCLSDVDP--EI 809

  Fly   828 QEAAYQSICDLLIIFSDKLARSEIEHIRGLEYKSRMDEHLILDNFVQHYVFSLKQDVA-----QD 887
            ||.|:..:.|||:|||.::.....:.:|.|.:.........|.:|:..:||....::.     :|
  Rat   810 QEQAFVLLSDLLLIFSPQMVVGGRDFLRPLVFFPEATLQSELASFLMDHVFLQPGELGNGQSQED 874

  Fly   888 ETRIEELHKKRNFLACYCKLVVYNIIPTMRAASIFKYYVKCYNDYGDIIKATLGKAREINKVNFA 952
            ..:||.||::|..||.:|||::|.::....|:.:||:|.|.|.|||||||.||.:||:|::...:
  Rat   875 HVQIELLHQRRRLLAGFCKLLLYGVLELDAASDVFKHYNKFYEDYGDIIKETLTRARQIDRCQCS 939

  Fly   953 MTLLLSLITVFKSL-QEQSEDGIVSKSSQEFVDLKELAKRFALTFGFDAIKNRESVAAIHRGGIY 1016
            ..|||||..::..| |||....:....:  |:::::||:||||:||...:.||:.|..:|:.||.
  Rat   940 RILLLSLKQLYTELIQEQGPQDLTELPA--FIEMRDLARRFALSFGPQQLHNRDLVVMLHKEGIK 1002

  Fly  1017 FAANK-EPDDPVRAPTRLLFLEVLNEFNYKLLKQDKKVIMSFLDKII-----PPAMPSSRAEEWQ 1075
            |:.:: .|....|.|..:.|||:|:||:.:|..|||::::|:|:|.:     .|:.|      |.
  Rat  1003 FSLSELPPAGSSREPPNIAFLELLSEFSPRLFHQDKQLLLSYLEKCLQRVSMAPSHP------WG 1061

  Fly  1076 PLILYRNSLLHGE-----TDQAPVASKRAYTRKRRDHDEEEEEEEDE 1117
            |:..|.:||...|     :.|.|..||:......|...|||...:.|
  Rat  1062 PVTTYCHSLHLVENTAEASSQGPPHSKKRCIEVPRRLQEEESSSQGE 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA	NP_477268.2	STAG	190..298	CDD:285686	67/107 (63%)
Stag3	NP_446182.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..110		13/54 (24%)
		STAG	188..296	CDD:400698	67/107 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1169		5/13 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1230..1256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353509
Domainoid	1	1.000	677	1.000	Domainoid score	I129
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	899	1.000	Inparanoid score	I361
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	1	1.000	-	-		otm45410
orthoMCL	1	0.900	-	-		OOG6_101510
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X570
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810