Protein Alignment SA1 and STAG3

DIOPT Version :10

• Sequence 1: NP_477268.2
• Gene: SA1 / 33974
• FlyBaseID: FBgn0020616
• Length: 1127
• Species: Drosophila melanogaster
• Sequence 2: XP_016867173.2
• Gene: STAG3 / 10734
• HGNCID: 11356
• Length: 1242
• Species: Homo sapiens
• Alignment Length: 1152
• Identity: 451/1152 - (39%)
• Similarity: 687/1152 - (59%)
• Gaps: 92/1152 - (7%)

  Fly    30 STSDADSPTKRMTRLRARGGVRDKPPIIDDDEDDFFAPIARKRKTPATRKGPTERKERVERPRKE 94
            |:|.|..|...........|..|.  ::.|::.||...:.|..|..|.:: |.:.....:.|:|.
Human    20 SSSSASLPFDDRDSNHTSEGNGDS--LLADEDTDFEDSLNRNVKKRAAKR-PPKTTPVAKHPKKG 81

  Fly    95 PVDKGHHERIDSEREITTDENSLYYIVRHSKNPIASIVDQWIEQYKANRETALVALMQFFINASG 159
            ......|.|..||    ...|.|:..|:.:|:.:.|:||:|::.||.:::...:.|:.|||.:.|
Human    82 SRVVHRHSRKQSE----PPANDLFNAVKAAKSDMQSLVDEWLDSYKQDQDAGFLELVNFFIQSCG 142

  Fly   160 CKGKISEDIQYPVDHTSIIRRMTEEFDEESGEYPLIMSGTQWRKFKNNFCDFVQTLVKQCQYSII 224
            |||.::.::...:.::.||:.:||:|:|:||:||||..|..|:||:.:||:||:|||.|||||::
Human   143 CKGIVTPEMFKKMSNSEIIQHLTEQFNEDSGDYPLIAPGPSWKKFQGSFCEFVRTLVCQCQYSLL 207

  Fly   225 YDQFLMDNVISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVALLVSNNFDNAAKQFEAERVKSR 289
            ||.|.||::||||||||||||||||||:|||||||||:||.|||.:|.:.||..:|:||||.|..
Human   208 YDGFPMDDLISLLTGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSVHQDNNQRQYEAERNKGP 272

  Fly   290 DRRASDRLDSLMTKRSELEENMDEIKSMLTYMFKSVFVHRYRDSLPDIRAICMAEIGIWMENYPQ 354
            .:||.:||:||:.||.||:|:.:||:.|:..:|:.||||||||.||:|||||:.|||.||::|..
Human   273 GQRAPERLESLLEKRKELQEHQEEIEGMMNALFRGVFVHRYRDVLPEIRAICIEEIGCWMQSYST 337

  Fly   355 NFLDDSYLKYIGWTLHDKIGEVRLRCLQSLLPLYEKDELKGKLELFTSKFKDRIVAMTLDKEFEV 419
            :||.||||||||||||||..||||:|:::|..||...:|..:||||||:||||:|:|.:|:|::|
Human   338 SFLTDSYLKYIGWTLHDKHREVRLKCVKALKGLYGNRDLTTRLELFTSRFKDRMVSMVMDREYDV 402

  Fly   420 SVHAVKLVISILKIHPEILADKDCEIVYELVYSSHRGVAQAAAEFLNVRLFHLTADM-----EET 479
            :|.||:|:|.|||....:|.|.|||.||.:||:||||:|.||.|||..:||:...::     .|.
Human   403 AVEAVRLLILILKNMEGVLTDADCESVYPVVYASHRGLASAAGEFLYWKLFYPECEIRMMGGREQ 467

  Fly   480 KTKRGKVRMPNTPLVRDLVQFFIESELHEHGAYLVDSFID-SNDMVRDWECMTDLLLEEPGPNEE 543
            :...|..|    ...:.|:.||:|||||:|.||||||..| :...::|||.:|.||||:    ::
Human   468 RQSPGAQR----TFFQLLLSFFVESELHDHAAYLVDSLWDCAGARLKDWEGLTSLLLEK----DQ 524

  Fly   544 VLDNKQESTLIEIMVSSVKQSATGEVPVGRASNRKCTLSAKELKAIQDEKAKLTEHFIVTLPSLL 608
            .|.:.||||||||:|||.:|::.|..||||.:.|| .|::||.|...|::.|||||.|..||.||
Human   525 NLGDVQESTLIEILVSSARQASEGHPPVGRVTGRK-GLTSKERKTQADDRVKLTEHLIPLLPQLL 588

  Fly   609 EKYQADSEKLANLLAVPQYFDLNLYTTNRQEGNLQALLDRINQVMSMHTGREVLETCAKTLECLC 673
            .|:.||:||:..||.:...|||::|.|.|.|.:|:..|.::.:|:..|....|||..|..|..||
Human   589 AKFSADAEKVTPLLQLLSCFDLHIYCTGRLEKHLELFLQQLQEVVVKHAEPAVLEAGAHALYLLC 653

  Fly   674 AEGSATYTRCNIARSNIIESAVNKYKDAIEEWRNLIQGEETPNEDDIYNITITLKVLSILYSSHN 738
            ......::|.:.|||.:::...::::..:||   |:|.... :||::||:..|||.||..|::|:
Human   654 NPEFTFFSRADFARSQLVDLLTDRFQQELEE---LLQSSFL-DEDEVYNLAATLKRLSAFYNTHD 714

  Fly   739 LNPWELFKSLFQDVEEAQSKENIDRCLPNEALVYCIEACYFSISWGLQYVENECESVNVTEVVAE 803
            |..|||::...|.:::|.....:    |::.::..:...||||.|.|.::.....|   .:.::.
Human   715 LTRWELYEPCCQLLQKAVDTGEV----PHQVILPALTLVYFSILWTLTHISKSDAS---QKQLSS 772

  Fly   804 LRNNLDTFMGACFELTRDGPTVQIQEAAYQSICDLLIIFSDKLARSEIEHIRGLEYKSRMDEHLI 868
            ||:.:..|...|.....|..| :|||.|:..:.|||:|||.::.....:.:|.|.:.........
Human   773 LRDRMVAFCELCQSCLSDVDT-EIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFPEATLQSE 836

  Fly   869 LDNFVQHYVFSLKQDVA-----QDETRIEELHKKRNFLACYCKLVVYNIIPTMRAASIFKYYVKC 928
            |.:|:..:||....|:.     :|..:||.||::|..||.:|||::|.::....|:.:||:|.|.
Human   837 LASFLMDHVFIQPGDLGSGDSQEDHLQIERLHQRRRLLAGFCKLLLYGVLEMDAASDVFKHYNKF 901

  Fly   929 YNDYGDIIKATLGKAREINKVNFAMTLLLSLITVF-KSLQEQSEDGIVSKSSQEFVDLKELAKRF 992
            |||||||||.||.:||:|::.:.:..|||||..:: :.|||....|:  .....|:::::||:||
Human   902 YNDYGDIIKETLTRARQIDRSHCSRILLLSLKQLYTELLQEHGPQGL--NELPAFIEMRDLARRF 964

  Fly   993 ALTFGFDAIKNRESVAAIHRGGIYFAANK-EPDDPVRAPTRLLFLEVLNEFNYKLLKQDKKVIMS 1056
            ||:||...::||:.|..:|:.||.|:.:: .|......|..|.|||:|:||:.:|..|||::::|
Human   965 ALSFGPQQLQNRDLVVMLHKEGIQFSLSELPPAGSSNQPPNLAFLELLSEFSPRLFHQDKQLLLS 1029

  Fly  1057 FLDKII-----PPAMPSSRAEEWQPLILYRNSLLHGE-----TDQAPVASKRAYTR-----KRRD 1106
            :|:|.:     .|..|      |.|:..|.:||...|     :.|...:|||....     .|.|
Human  1030 YLEKCLQHVSQAPGHP------WGPVTTYCHSLSPVENTAETSPQVLPSSKRRRVEGPAKPNRED 1088

  Fly  1107 HDEEEEE----------------------------EEDEEEHNDPDY 1125
            ....:||                            |.:||:.::.|:
Human  1089 VSSSQEESLQLNSIPPTPTLTSTAVKSRQPLWGLKEMEEEDGSELDF 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SA1	NP_477268.2	IRR1	66..>426	CDD:227824	181/359 (50%)
		STAG	190..303	CDD:462502	73/112 (65%)
STAG3	XP_016867173.2	IRR1	37..>394	CDD:227824	179/363 (49%)
		STAG	173..286	CDD:462502	73/112 (65%)