Protein Alignment CG18304 and Mtcl3

DIOPT Version :10

• Sequence 1: NP_001260170.1
• Gene: CG18304 / 33969
• FlyBaseID: FBgn0031869
• Length: 1901
• Species: Drosophila melanogaster
• Sequence 2: NP_080414.2
• Gene: Mtcl3 / 67412
• MGIID: 1914662
• Length: 945
• Species: Mus musculus
• Alignment Length: 1183
• Identity: 233/1183 - (19%)
• Similarity: 408/1183 - (34%)
• Gaps: 414/1183 - (34%)

  Fly   105 IDEPDNVARRPPATASTSRAAS----------SAEDQDVAVTVKLPVPPRRHTTALDIKEVEHAI 159
            :.:|.:....|.||::::.||:          |.:.|    ..:.|..||           ::::
Mouse     1 MSQPPSGGAAPAATSASAAAAATEARMHPEGCSRKQQ----RAQSPARPR-----------DNSL 50

  Fly   160 TPPTRVTSSPSKTSSIPDELVILSTDSLAERVRKMNLLKKQRSLN-------SRENSR------E 211
            ......|.||            |........||:..|.::|:..|       |...||      |
Mouse    51 RQTAGATRSP------------LGVGPKLNSVRQQQLQQQQQQGNKITGRSTSGTGSRGLGGGAE 103

  Fly   212 RSVPRREEESESTATPTPVVPD--RPERSKSGTSLNQLAQAEQKRAALP----------PKKV-- 262
            ::||         :.|...||.  :|.....|:....||....:|:..|          |.||
Mouse   104 KAVP---------SIPKGAVPGAVQPAPGAEGSPAAILASVSFRRSGQPEEAPREIESGPSKVGE 159

  Fly   263 ---------------------------------------AVASTTTASSSNSSSTSLKTSNSTSA 288
                                                   .|.:|...|   |.:..:..|..|:|
Mouse   160 PPPLGGVGGGGEGGGAGGGPGDREGGAPQPPPPRGWRGKGVRATQRGS---SVAEGVSPSPPTAA 221

  Fly   289 SNEVKVVTSTSSSSTSSSSVRR------KEA---DSVASKEIKRQTVPAASISHSNSTSSTASTA 344
            :::.....|.:|.|.|:.|...      ||.   ..:....:|::...||:.:....|.: ....
Mouse   222 TSKTPGPGSRNSGSGSTGSGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAAQMHTKN-GGGG 285

  Fly   345 SKSQDTNGMQEQMKALKLELET-MKTRAE----KAEREKSDILLRRLASMDTASNRTAASEALNL 404
            |:|....|.....:.|.:...: |...||    .||...|.      .:|..|:..::...:..|
Mouse   286 SRSSPVAGAPAICEPLVVPSSSPMAAAAEGPQQSAEGNGSG------GAMQAAAPPSSQPHSQQL 344

  Fly   405 QQKLNEMKEQLDRVTEDKRKLNLRMKELENKGSESELRRKLQAAEQICEELMEENQSAKKEILNL 469
            |:: .:|:|::                                     |:|.|||::.|.||..|
Mouse   345 QEQ-EDMQEEM-------------------------------------EKLREENETLKNEIDEL 371

  Fly   470 QAEMDEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRKIETLEQERQSSFNAELSNK 534
            :.||||::|||.:::......::.:||:|.||||||.::|:|::||  .|...:....:.||
Mouse   372 RTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERK--RLRYAQTGEIDGEL--- 431

  Fly   535 IKKLEEELRFSNELTRKLQAEAEELRNP--------GKKKAPMLGV-LGKSTSAD--AKFTRESL 588
            ::.||::|:.:.:::.:|..|.|.:...        .|.:..::.| :.|....:  .|....||
Mouse   432 LRSLEQDLKVAKDVSVRLHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSL 496

  Fly   589 TRGGSQEDPQHLQRELQDSIERET-DLKDQLKFAEEELQRLR------DRERKRVRFSCGTQTEV 646
            .|.||::.|:..::..|...|.:. |||.||:|.:||...:|      |:|:.|
Mouse   497 KRRGSKDLPKSEKKAQQTPTEDDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDR----------- 550

  Fly   647 PLEVVAFPRGTQTVATVQSDMSTSVENLVTSNVAVTQTDFEVPDRNVSIERETMSSPFAGLFPPS 711
                  |....|...:...|:                 |..:|...            || .|||
Mouse   551 ------FEHELQKYRSFYGDL-----------------DSPLPKGE------------AG-GPPS 579

  Fly   712 SSSRVGQSGSLLFPSAISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDPAELRILLEL 776
            :..                                                     |||::.|.|
Mouse   580 TRE-----------------------------------------------------AELKLRLRL 591

  Fly   777 NEQEASILRLKVEDLEKENAESKKYVRELQAK---LRQDSSNGSKSSLLSLGTSSSAAEKKVKTL 838
            .|:||:||..|:.:||.||       |.|:|:   ||.:..|||.:.|:             :..
Mouse   592 VEEEANILGRKIVELEVEN-------RGLKAELDDLRGEDFNGSSNPLM-------------REQ 636

  Fly   839 NEELVQLRRTLTEKEQTVDSLKNQLSKLDTLETENDKLAKENKRLLA-LRKASEKTGEVDQKMKE 902
            :|.|.:||:.|...|...:.|:..::.|:          ::|||:.| |.|...|:...|.....
Mouse   637 SESLSELRQHLQLVEDETELLRRNVADLE----------EQNKRITAELNKYKYKSSGHDSSRHH 691

  Fly   903 SLAQAQRERDEL-TARL-------KRMQLEAEDKLPPRTAKRVNDLTPKSHLKKWVEELEDEISE 959
            ..|:.:..::|| .|||       |.|||:.|:::.....:|. ||.  |||.
Mouse   692 DNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRY-DLA--SHLG------------ 741

  Fly   960 MRVMLSSSGTDQLKALQSAKGALEEDLRKCKQKLSLAEGDVQRLKLLNGSSSKVSELEQKLKRGD 1024
                :..|..|......:.|...::|.|...:|   .||.:      .|.|.            .
Mouse   742 ----IRGSPRDSDAESDAGKKESDDDSRPPHRK---REGPI------GGESD------------S 781

  Fly  1025 EEAKKLNSKLKDLEDKVKKQEAQLKLGET-----SKSTWESQSKREKEKLSSLEKDMEKQAKEKE 1084
            ||.:.:.|                 |..|     :...| .:|..:::::..:..:.|:..|..:
Mouse   782 EEVRNIRS-----------------LTPTRSFYPTPGPW-PKSFSDRQQMKDIRSEAERLGKTID 828

  Fly  1085 KL---------EAKISQLDAELLSAKKSAEKSKSSLEKEIKDLKTKASKSDSKQVQDLKKQVEEV 1140
            :|         ||:|...:.:|.......:......|.|:........|:..|::|..   ::.:
Mouse   829 RLIADTSTIITEARIYVANGDLFGLMDEEDDGSRIREHELLYRINAQMKAFRKELQTF---IDRL 890

  Fly  1141 QASLSAEQKRYED 1153
            :...||:.:..|:
Mouse   891 EVPKSADDRGAEE 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	SMC_prok_B	<354..1093	CDD:274008	165/787 (21%)
		SMC_prok_B	831..>1544	CDD:274008	65/346 (19%)
		PHA03307	1657..>1901	CDD:223039
Mtcl3	NP_080414.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..250		50/287 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..293		5/28 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..366		17/102 (17%)
		SMC_prok_B	<365..713	CDD:274008	113/482 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	494..522		8/27 (30%)
		SOGA	519..613	CDD:463264	38/200 (19%)
		SOGA	639..727	CDD:463264	26/97 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..811		17/124 (14%)