Protein Alignment CG18304 and Mtcl2

DIOPT Version :10

• Sequence 1: NP_001260170.1
• Gene: CG18304 / 33969
• FlyBaseID: FBgn0031869
• Length: 1901
• Species: Drosophila melanogaster
• Sequence 2: NP_001158135.1
• Gene: Mtcl2 / 320706
• MGIID: 2444575
• Length: 1654
• Species: Mus musculus
• Alignment Length: 1843
• Identity: 391/1843 - (21%)
• Similarity: 671/1843 - (36%)
• Gaps: 566/1843 - (30%)

  Fly   222 ESTAT---PTPVVPDRPERSKSGTSLNQLAQAEQKRAALP--PKKVAVASTTTASSSNSSSTSLK 281
            ||:|.   |.|......||.||            .||..|  ||.||..|...........::..
Mouse     7 ESSARGYGPPPAPAPAAERKKS------------HRAPSPARPKDVAGWSLAKGRRGTGPGSATA 59

  Fly   282 TSNSTSASNEVK---VVTSTSSSSTSSSSVRRKEADSVASKEIKRQTV----PAASISHSNSTSS 339
            ...::||..:.|   |...|..:....:.||    ..|.:|...|...    |....|.::|:|.
Mouse    60 CGTASSARPDKKGRAVAPGTRGTGPRVAGVR----TGVRAKGRPRPGTGPRPPPPPPSLTDSSSE 120

  Fly   340 TASTASKSQDTNGMQEQMKALKLELETMKTRAEKA--------------EREKSDILLRRLASMD 390
            .:..||         |:.:.|.||| .:.:.||.|              ..:......|..||.|
Mouse   121 VSDCAS---------EEARQLGLEL-ALSSDAESAAGGPAGTRTGQPPQPAQSGQQPPRPPASPD 175

  Fly   391 TASNRTAASEALNLQQKLNEMKEQLDRVTEDKRKLNLRMKELENKGSESELRRKLQAAEQICEEL 455
            ..|  .|||...:.:..|:......| :||:       |.:....|...||           |||
Mouse   176 EPS--VAASSVGSSRLPLSASLAFSD-LTEE-------MLDCGPGGLVREL-----------EEL 219

  Fly   456 MEENQSAKKEILNLQAEMDEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRKIETLE 520
            ..||...|.||..|:|||.|::|.:.:::|.....|::.|::|:|.||||.::|:|::|:  :|.
Mouse   220 RSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERR--SLR 282

  Fly   521 QERQSSFNAELSNKIKKLEEELRFSNELTRKLQAEAEELRNPGKKKAPMLGVLGKSTSADAKFTR 585
            ..:....:.||   |:.||::::.|.:::.:|..|.|.:    :||...|
Mouse   283 AAQTGQVDGEL---IRGLEQDVKVSKDISMRLHKELEVV----EKKRMRL--------------- 325

  Fly   586 ESLTRGGSQEDPQHLQRELQDSIERETDLKDQLKFAEEELQRLRDRE-RKRVRFSCGTQTEVPLE 649
                    :|:.:.|::.|     .||:|..|:  .:.||.|.|:.. :||...|.|...:.|
Mouse   326 --------EEENEGLRQRL-----IETELAKQV--LQTELDRPREHSLKKRGTRSLGKTDKKP-- 373

  Fly   650 VVAFPRGTQTVATVQSDMSTSVENLVTSNVAVTQTDFEVPDRNVSIERETMSSPFAGLFPPSSSS 714
                     |.....:|:...:......:..:.:...::...|.|::.|.:.  :..|:
Mouse   374 ---------TAQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK--YRSLY------ 421

  Fly   715 RVGQSGSLLFPSAISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDPAELRILLELNEQ 779
                 |.|  .:|:|       ..:|:..||...                   .||::.|:|.|:
Mouse   422 -----GDL--DAALS-------AEELADAPHSRE-------------------TELKVHLKLVEE 453

  Fly   780 EASILRLKVEDLEKENAESKKYVRELQAKLRQDSSNG------SKSSLLSLG--TSSSAAE--KK 834
            ||::|..::.:||.||       |.|:|::.....:|      ::.:..|||  ...|.||  :.
Mouse   454 EANLLSRRIVELEVEN-------RGLRAEMDDMKDHGGGGGPEARLAFSSLGGECGESLAELRRH 511

  Fly   835 VKTLNEELVQLRRTLTEKEQTVDSLKNQLSKLDTLETENDKLAKENKRLLALRKASEKTGEVDQK 899
            ::.:.||...|||:..|.|.....|.|:|:|..: |.|.|....|           :....:.:.
Mouse   512 LQFVEEEAELLRRSSAELEDQNKLLLNELAKYRS-EHELDVTLSE-----------DSCSVLSEP 564

  Fly   900 MKESLAQAQRERDELTARLKRMQLEAEDKLPPRTAKRVNDLTPKSHLKKWVEELEDEISEMRVML 964
            .:|.||.|:.:..||:.::|::|.                                   |.||:|
Mouse   565 SQEELAAAKLQIGELSGKVKKLQY-----------------------------------ENRVLL 594

  Fly   965 SSSGTDQLKALQSAKGALEEDLRKCKQKLSLAEGDVQRLKLLNGSSSKVSELEQKLKRGDEEAKK 1029
            |:.....|.:.||.:..||.|          ||.                        ||
Mouse   595 SNLQRCDLASCQSTRPMLETD----------AEA------------------------GD----- 620

  Fly  1030 LNSKLKDLEDKVKKQEAQLKLGETSKSTWESQSK-REKEKLSSLEKDMEKQAKEKEKLEAKISQL 1093
                        ..|.....||||.:.......: ||.|.|..|        :|:..|.:|  .:
Mouse   621 ------------SAQCVPAPLGETLEPHAARLCRAREAEALPGL--------REQAALVSK--AI 663

  Fly  1094 DAELLSAKKSAEKSKSSLEKEIKDLKTKASKSDSKQVQDLKKQVEEVQASLSAEQKRYEDLNNHW 1158
            |..:..|...:...:..|:.|..||:...:..:|:..:|.|.    :.|
Mouse   664 DVLVADANGFSVGLRLCLDNECADLRLHEAPDNSEGPRDAKL----IHA---------------- 708

  Fly  1159 EKLSEETILMRAQLTTEKQSLQAELNASKQKIAEMDTIRIERTDMA-----RKLSEAQKRIADL- 1217
                   ||:|..:      ||.||||..:|           .|:|     ::..|....:..|
Mouse   709 -------ILVRLSV------LQQELNAFTRK-----------ADVALGSSGKEQPEPFPALPALG 749

  Fly  1218 ---QAKALKTVNGNGAEYERTVLKNKLAEKEHEYERLRRENEMNIDLVFQ----------LRKDN 1269
               .||.:......|::::....::.|     |:|...||.....||..:          ..:||
Mouse   750 SQGPAKEIMLSKDLGSDFQPPDFRDLL-----EWEPRIREAFRTGDLESKPDPSRNFRPYRAEDN 809

  Fly  1270 DDLNGKLSDYNRI-EQAQSSLNGHGARREAEIRELKEQLQSTELQMKSEVA------TVRLRYEQ 1327
            |....::.|...: .:|..||.|           |:||| |.|.|::.|.|      .|:|:.:|
Mouse   810 DSYASEIKDLQLVLAEAHDSLRG-----------LQEQL-SQERQLRKEEADSFNQKMVQLKEDQ 862

  Fly  1328 QVKNLSGEL----TSMQRQCER---------FKKDRDAFK-QMLEVAQKKIGDLKANNTGRQSRG 1378
            |...|..|.    .|:||:.|:         ..::...|| ..|.:..|....||     |..:|
Mouse   863 QRALLRREFELQSLSLQRRLEQKFWSQEKNILVQESQQFKHNFLLLFMKLRWFLK-----RWRQG 922

  Fly  1379 SMHSSDDDDKSKIAYLEQQIGHLEDQLVESRLESSKIKT-ELVSERSANE-IK-ISEMQSKLNE- 1439
            .:..|::||..::..:::....:|::.:.::...:|..| |..::.:.|| || :::|:..|.|
Mouse   923 KVLPSEEDDFLEVNSMKELYLLMEEEEMNAQHSDNKACTGESWTQNTPNECIKTLADMKVTLKEL 987

  Fly  1440 ------------------------FEEERV------------IGSGSTKLPGMKTKLELSWQKER 1468
                                    :|.||.            .|.|:::.||...|..|  |:||
Mouse   988 CWLLQDERRGLTELQQQFAKAKATWETERAELKGHASQMELKAGKGASERPGPDWKAAL--QRER 1050

  Fly  1469 EDQQRLLQETSTLARDLRQTLFEVERERDKERLESKRKLDQIKRATEEEMEEGRKKIAELQ--CD 1531
            |:||.||.|:.:...:|.:.|...||...:|:|:...:|...|:..|::::|.:.::::||  .:
Mouse  1051 EEQQHLLAESYSAVMELTRQLQLSERHWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAAE 1115

  Fly  1532 LLELRDVHAKLRTSNEKLRRERERYEKELIKRRMEAD-GGD----RKVGALLQTVDELVKIAPDL 1591
            ...|:....:.:.::.|..|..:.::||.:.   ||: ||.    .|..:.:...:.|:..:|.|
Mouse  1116 PWVLKHSDMEKQDNSWKEARSEKTHDKEGVS---EAELGGTGLKRTKSVSSMSEFESLLDCSPYL 1177

  Fly  1592 KIVGSGGSARSSSSSGYDKNLRPEQPNVRRSRSPSPTLSSSQITSVLARLAEASEELRKFQRVNE 1656
                :||.||       :|.|    ||       .|..:                    |.....
Mouse  1178 ----AGGDAR-------NKKL----PN-------GPAFA--------------------FVSTEP 1200

  Fly  1657 DEQERSRMRRSNLRRAASQENDPHGST---SSVASAAGSQRGGGRLSRN-SSNNGSLIRKSLSLD 1717
            .|.|:....::.|            ||   |.:.|.|..:..|.::.|: ::.:.:.||...|..
Mouse  1201 VEPEKDAKEKAGL------------STRDCSHIGSLACQEPAGRQMQRSYTAPDKTGIRVYYSPP 1253

  Fly  1718 HSIQRDQNIWRQDDGSV---------SSMQSIDSELGGLVRDSS---LDSRLDSRLSGGSTQSDI 1770
            .:.:....:....:|.:         ::.....:|..||...|.   |.:....||.|||..|..
Mouse  1254 VARRLGVPVVHDKEGKILIEPGFLFTTAKPKESAEADGLAESSYSRWLCNFSRQRLDGGSGASTS 1318

  Fly  1771 PRGPRKKKKGIMGKLRSLTKSSRNSESEISIQGSDSDISVASDMRSSKKDLRGRL-SGMFKRSGS 1834
            ..||                 :..:..:..:.|:.||     ||:.....:|..: ||..:|...
Mouse  1319 GSGP-----------------AFPALHDFEMSGNMSD-----DMKEITNCVRQAMRSGSLERKVK 1361

  Fly  1835 ASRSESMERAGSDQRPVAVTVVGHPDGPQPREPPPANSLTPR-----PIRS-------------I 1881
            .:.|:::..|....:.:....||....| ||....:.|.:||     .:||             |
Mouse  1362 NTSSQTVGVATVGTQTIRTVSVGLQTDP-PRSSLHSKSWSPRSSSLVSVRSKQISSSLDKVHSRI 1425

  Fly  1882 PKP---PSAGAPTTPTTRRRVAK 1901
            .:|   |..|:|  ...||.|:|
Mouse  1426 ERPCCSPKYGSP--KLQRRSVSK 1446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	SMC_prok_B	<354..1093	CDD:274008	165/764 (22%)
		SMC_prok_B	831..>1544	CDD:274008	167/797 (21%)
		PHA03307	1657..>1901	CDD:223039	56/281 (20%)
Mtcl2	NP_001158135.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..188		49/208 (24%)
		PHA03307	28..>211	CDD:223039	46/218 (21%)
		Required for association with Golgi apparatus membrane	209..238		14/39 (36%)
		SMC_prok_B	<214..541	CDD:274008	101/435 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..379		10/41 (24%)
		SOGA	378..472	CDD:463264	25/141 (18%)
		SOGA	504..593	CDD:463264	28/135 (21%)
		SCP-1	<814..>1109	CDD:114219	74/313 (24%)
		GumC	<998..>1115	CDD:442439	30/118 (25%)
		DUF4482	1065..1203	CDD:464333	35/182 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1122..1146		4/23 (17%)
		KR-rich domain required for microtubules binding	1406..1505		11/43 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1427..1450		8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1537..1560
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1627..1654