Protein Alignment CG18304 and Mtcl1

DIOPT Version :10

• Sequence 1: NP_001260170.1
• Gene: CG18304 / 33969
• FlyBaseID: FBgn0031869
• Length: 1901
• Species: Drosophila melanogaster
• Sequence 2: XP_038940728.1
• Gene: Mtcl1 / 316764
• RGDID: 1308319
• Length: 2010
• Species: Rattus norvegicus
• Alignment Length: 2064
• Identity: 410/2064 - (19%)
• Similarity: 715/2064 - (34%)
• Gaps: 682/2064 - (33%)

  Fly   116 PATA--STSRAASSAEDQDVAVTVKLPVPPRRHTTALDIKEVEHAITPPTRVTSSPSKTSSIPDE 178
            ||||  |..||.:.|..:..::|.|.|..|             .:...|.|::..........|
  Rat    56 PATATPSAGRAPTPAAPRSPSLTGKAPPSP-------------GSPAAPGRLSRRSGVVPGAKD- 106

  Fly   179 LVILSTDSLAERVRKMNLLKKQRSLNSRENSRERSVP-RREEESESTATPTPVVPDRPERSKSGT 242
                               |......:|.....::.| .|.......|.|...| .||..::...
  Rat   107 -------------------KPPPGAGARSAGGAKAAPGTRRATRAGPAEPLSRV-GRPAGAEPPP 151

  Fly   243 SLNQLAQAEQ------KRAALPPKKVAVASTTTAS---------SSNSSSTSLKTSNSTSASNEV 292
            :|::..:|::      .||.:||...|.....|.|         |...||:.|....|...|:|.
  Rat   152 ALSKGRKAKRGPGTPPARAVVPPAPAARVPAVTLSVTSVAGTRISHTDSSSDLSDCASEPLSDEQ 216

  Fly   293 KVVTSTSS---SSTSSSS---VRRKEADSVASKE-----------IKRQTVPAASISHSNSTSST 340
            :::.:.||   |.|.||.   :|.....|..|:.           :....|..|.:...:|...|
  Rat   217 RLLPAASSDAESGTGSSDREPLRGAPTPSSGSRGPPPGSPEPPTLLAAPPVAGACLGGRSSPGGT 281

  Fly   341 ASTA---SKSQDTNGMQEQMKALKLELETMKTRAEKAEREKSDILLRRLASMDTASNRTAASEAL 402
            .|.:   ...:|..|                    :|..|::.:             .|....:|
  Rat   282 PSGSPGPGSQEDVGG--------------------RAPPERTIL-------------GTPKEPSL 313

  Fly   403 NLQQKLNEMKEQLDRVTEDKRKLNLRMKELENKGSESELRRKLQAAEQICEELMEENQSAKKEIL 467
            ..|.:|..:.|                        |.||.|::       |||..||...|.|:.
  Rat   314 GEQPRLLVVAE------------------------EEELLREM-------EELRSENDYLKDELD 347

  Fly   468 NLQAEMDEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRKIETLEQERQSSFNAELS 532
            .|:|||:|::|::.:::......|:::|::|.||||||.::|:|:::|  :|:.......:.||
  Rat   348 ELRAEMEEMRDSYLEEDGYQLQELRRELDRANKNCRILQYRLRKAEQK--SLKVAETGQVDGEL- 409

  Fly   533 NKIKKLEEELRFSNELTRKLQAEAEELRNPGKK--------KAPMLGVLGKSTSADA------KF 583
              |:.||::|:.:.:::.:|..|.|.:.....|        :..|:.|   ..|..|      :.
  Rat   410 --IRSLEQDLKVAKDVSVRLHHELETVEEKRAKAEDDNETLRQHMIEV---EISRQALQNELERL 469

  Fly   584 TRESLTRGGSQEDPQHLQRELQDSI----------ERETDLKDQLKFAEEELQRLRDRERKRVRF 638
            ...||.|.||:|  .:.:::|.:.|          :...|||.||:||:||...:|.:..|..|
  Rat   470 RESSLKRRGSRE--IYKEKKLVNQITLPRAVLAWQDDSADLKCQLQFAKEEASLMRKKMAKLGR- 531

  Fly   639 SCGTQTEVPLEVVAFPRGTQTVATVQSDMSTSVENLVTSNVAVTQTDFEVPDRNVSIERETMSSP 703
               .:.|:..|:       |...::..|:                 |..:|...
  Rat   532 ---EKDELEQEL-------QKYKSLYGDV-----------------DSPLPTGE----------- 558

  Fly   704 FAGLFPPSSSSRVGQSGSLLFPSAISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDPA 768
             || .|||:..                                                     |
  Rat   559 -AG-GPPSTRE-----------------------------------------------------A 568

  Fly   769 ELRILLELNEQEASILRLKVEDLEKENAESKKYVRELQAKLRQDSSNGSKSSLLSLGT------- 826
            ||::.|:|.|:|||||..|:.:||.||...|..:.::  :::.:....|:..:..:.|
  Rat   569 ELKLRLKLVEEEASILGRKIVELEVENRGLKAEMEDI--RVQHEREGTSRDHVPGIPTSPFGDSM 631

  Fly   827 -SSSAAEKKVKTLNEELVQLRRTLTEKEQTVDSLKNQLSKLDTLETENDKLAKENKRLLALRKAS 890
             ||:...:.::.:.||...|||:::|.|.....|.::|||..         .:.::....|....
  Rat   632 ESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFK---------FEPHQESGWLGDGV 687

  Fly   891 EKTGEVDQKMKESLAQAQRERDELTARLKRMQLEAEDKLPPRTAKRVNDLTPKSHLKKWVEELED 955
            .|.......::|.|..|:.:.|||:.::  ::|:.|::|....|:|. ||.  :||
  Rat   688 SKGPGASAPLQEELKSARLQIDELSGKV--LKLQCENRLLLSNAQRC-DLA--AHL--------- 738

  Fly   956 EISEMRVMLSSSGTDQLKALQSAKGALEEDLRKCKQKLSLAEGDVQRLKLLNGSSSKVSELEQKL 1020
                                         .||....:.|.||.|..:
  Rat   739 -----------------------------GLRAPSPRDSDAESDAGK------------------ 756

  Fly  1021 KRGDEEAKKLNSKLKDLEDKVKKQEAQLKLGETSKSTWESQSKREKEKLSSLEKDMEKQAKE--- 1082
            |..|.|           |.::.:.:.:..:|      .||.|:...||.|........:|.|
  Rat   757 KESDGE-----------EGRLPQPKREGPVG------GESDSEDMFEKTSGFGSGKPSEASEPCP 804

  Fly  1083 ------KEKLEAKIS-QLDAELLSAKKSAEKSKSSLEKEIKDLKTKASKSDSKQVQDLKKQVEEV 1140
                  :|..|..:: :|:|:.|  :::.|:..|..:..|:|...:.:.|.|..||.      |.
  Rat   805 TELLRVREDTECLVTMKLEAQRL--ERTVERLISDTDGFIRDSGLRGNGSASPGVQG------EG 861

  Fly  1141 QASLSAEQKRYEDLNNHWEKLSEETILMRAQLTTEKQSLQAELNASKQKIAEMDTIRIERTDMAR 1205
            :.||: |....|.:|...:...:|......|::.....| :.|:...:..:.:.|:    |.::|
  Rat   862 EGSLN-EPHLLETINGRMKAFRKELQAFLEQMSRIVDGL-SPLSHLTESSSFLSTV----TSVSR 920

  Fly  1206 --KLSEAQKRIA-DLQAKALKTVN---GNGAEYERTVLKNKLAEKEHEY-------ERLRRENEM 1257
              .:....|.:. |||:|..:.:.   |.....||..|:.:...:.|.:       ..|..::..
  Rat   921 DSPIGTLGKELGPDLQSKLREQLEWQLGQDRGDEREGLRLRATRELHRHADGDSGSHGLGGQSCF 985

  Fly  1258 NIDL-----VFQLRKDNDDLNGKLSDYNRIEQAQSSLNGHGARREAEIRELKEQ----LQSTELQ 1313
            |::|     :.:.....::|.|:|....|:.|.::....:      :||:::|.    |:..||:
  Rat   986 NLELRGSPVLPEQSVSVEELQGQLQQAARLHQEETETYTN------KIRKMEEDHLYALRWKELE 1044

  Fly  1314 MKSEVATVRLRYEQQVKNLSGELTSMQRQCERFKKDRDAF--------------KQMLE------ 1358
            |.|    :.|:.....:..|.|...:|::....|::...|              |||.|
  Rat  1045 MHS----LALQNTLHKRTWSDEKNMLQQELRSLKQNIFLFYVKLRWLLKHWRQGKQMEEGGEDFA 1105

  Fly  1359 ----------VAQKKI-GDLKANNTGRQ--SRG----------------SMHSS-----DDDDKS 1389
                      :|:..: |..:.:.|.::  .||                |.|.|     |....|
  Rat  1106 ESEHPENVPGLAELGVQGGHRTDGTDQEGTDRGCGLPMGEPAPHSPVQMSEHGSRLPTADGGPLS 1170

  Fly  1390 KIAYLEQQI-----GHLED---QLVESRLESSKIKTELVSERSANEIKISEMQSKLNEFEE--ER 1444
            |.....||:     ..|||   :|.|......:::.:..|:::|.:::.:.::.:|.:.||  |:
  Rat  1171 KQVVENQQLFRALKALLEDFRSELREDEHARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTEK 1235

  Fly  1445 VIGSGSTKLPGMKTKLELSWQKEREDQQRLLQETSTLARDLRQTLFEVERERDKERLESKRKLDQ 1509
            .:|...:...| |..|    :||||..|:||.::..|..|||..:...|:..::|::|...:||
  Rat  1236 SLGELDSSAEG-KGAL----KKEREVHQKLLADSHGLVMDLRWQIHHREKNWNREKVELLERLD- 1294

  Fly  1510 IKRATEEEMEEGRKKIAELQCDLLELRDVHAKLRTSNEKLRRERERYEKELIKRRMEADGGDRKV 1574
                 .|..|.||:|                      |:|....|:.:||...||.
  Rat  1295 -----NERQEWGRQK----------------------EELLWRVEQLQKEKSPRRS--------- 1323

  Fly  1575 GALLQTVDELVKIAPDLKIVGSGGSARSSSSSGYDKNLRPEQPNVRRSRSPS--PTLSSSQI--- 1634
            |:.|                   .|.|...:..|     |.|.::..||..|  |...:..|
  Rat  1324 GSFL-------------------CSPREDDNRPY-----PHQGSLHPSRPVSMWPCEDTDSIPFE 1364

  Fly  1635 TSVLARLAE-----ASEEL----RKFQRVNED---------EQERSRMRRSNLRRAAS------- 1674
            ...|::|.|     |||.|    ......:||         |:|.|  |:.||:||.|
  Rat  1365 DRPLSKLKESDRCSASENLYLDALSLDDDSEDPPPLRNCLAEEEES--RKGNLQRAVSVSCMSEF 1427

  Fly  1675 ---QENDPHGSTSSVASAAGSQRGGGRLSRNSSNNGSLIRKSLSLD-------HSIQRDQNIW-- 1727
               .:..|......:.||:..:.....|   |.::...|.:..|.|       ....|..::|
  Rat  1428 QRLMDVSPFLPEKGLPSASSREDVTPPL---SPDDLKYIEEFNSKDWDYTSPRAGADRPPDLWAD 1489

  Fly  1728 RQDDGSV------------------------SSMQS------------IDSELGG--LVRDSSLD 1754
            |.:.|.|                        .:|.|            :.:|..|  ::......
  Rat  1490 RTEVGRVGHEATAEPCPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRTHVLTEQSGVHVLHSPPAI 1554

  Fly  1755 SRLDSRLSGGSTQSDI-PRG------------------------------PRKKKKGIMGKLRSL 1788
            .|:||..|||..:|.: |.|                              ||..:..:.|.||.|
  Rat  1555 RRVDSIASGGEGRSRVDPEGPFPMSRARGNLADAKGGHPEPVLNRWPCTPPRHPRDCVEGSLRPL 1619

  Fly  1789 TKSSRNSESEIS-IQGSDSDISVASDMRSSKKDLRGRLSGMFKRSGSAS---RSESMERAGS--- 1846
            .:....|....| :...|...:::.||:.....:|..:.     ||.|.   |..:.:..||
  Rat  1620 DRPLCPSLGFASPLNSLDMSRNMSDDMKEVAFSVRNAMC-----SGPAEPQVRDMACQTNGSRTA 1679

  Fly  1847 DQRPVAVTVVGHPDGPQPREPPPANSLTPRPIRSIPKPPSAGAPTTPTT 1895
            ..:.:....||     ...|...|:.:|..|.:.:  .|.||..|||.:
  Rat  1680 GTQTIQTISVG-----LQTEALRASGVTSSPHKCL--TPKAGGGTTPVS 1721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	SMC_prok_B	<354..1093	CDD:274008	152/780 (19%)
		SMC_prok_B	831..>1544	CDD:274008	158/808 (20%)
		PHA03307	1657..>1901	CDD:223039	66/343 (19%)
Mtcl1	XP_038940728.1	PHA03307	7..>290	CDD:223039	54/267 (20%)
		SMC_N	330..>1111	CDD:481474	202/1004 (20%)
		SMC_prok_B	<342..659	CDD:274008	93/422 (22%)
		SOGA	504..598	CDD:463264	39/187 (21%)
		SOGA	633..725	CDD:463264	23/102 (23%)
		SMC_prok_B	<1167..>1323	CDD:274008	46/188 (24%)
		DUF4482	1269..1392	CDD:464333	39/183 (21%)