DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG18304 and MTCL2

DIOPT Version :10

Sequence 1:NP_001260170.1 Gene:CG18304 / 33969 FlyBaseID:FBgn0031869 Length:1901 Species:Drosophila melanogaster
Sequence 2:NP_542194.2 Gene:MTCL2 / 140710 HGNCID:16111 Length:1661 Species:Homo sapiens


Alignment Length:1851 Identity:382/1851 - (20%)
Similarity:670/1851 - (36%) Gaps:592/1851 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 PTPVVPDRPERSKSGTSLNQLAQAEQKRAALP--PKKVAVASTTTASSSNSSSTSLKTSNSTSAS 289
            |.|.....|||.||            .||..|  ||.||..|...........:::..|.:.|:.
Human    17 PAPAPAPAPERKKS------------HRAPSPARPKDVAGWSLAKGRRGPGPGSAVACSAAFSSR 69

  Fly   290 NEVK---VVTSTSSSSTSSSSVRRKEADSVASKEIKRQTV----PAASISHSNSTSSTASTASKS 347
            .:.|   |......:....:.||    ..|.:|...|...    |....|.::|:|..:..||  
Human    70 PDKKGRAVAPGARGAGVRVAGVR----TGVRAKGRPRSGAGPRPPPPPPSLTDSSSEVSDCAS-- 128

  Fly   348 QDTNGMQEQMKALKLELETMKTRAEKAEREKSDILLRR----------------------LASMD 390
                   |:.:.|.||| .:.:.||.|....:.:...:                      :|:..
Human   129 -------EEARLLGLEL-ALSSDAESAAGGPAGVRTGQPAQPAPSAQQPPRPPASPDEPSVAASS 185

  Fly   391 TASNRTAASEALNLQQKLNEMKEQLDRVTEDKRKLNLRMKELENKGSESELRRKLQAAEQICEEL 455
            ..|:|...|.:|.......||   ||                   ...|.|.|:|       |||
Human   186 VGSSRLPLSASLAFSDLTEEM---LD-------------------CGPSGLVREL-------EEL 221

  Fly   456 MEENQSAKKEILNLQAEMDEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRKIETLE 520
            ..||...|.||..|:|||.|::|.:.:::|.....|::.|::|:|.||||.::|:|::|:  :|.
Human   222 RSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERR--SLR 284

  Fly   521 QERQSSFNAELSNKIKKLEEELRFSNELTRKLQAEAEELRNPGKKKAPMLGVLGKSTSADAKFTR 585
            ..:....:.||   |:.||::::.|.:::.:|..|.|.:.   ||:|.:                
Human   285 AAQTGQVDGEL---IRGLEQDVKVSKDISMRLHKELEVVE---KKRARL---------------- 327

  Fly   586 ESLTRGGSQEDPQHLQRELQDSIERETDLKDQLKFAEEELQRLRDRERKRVRFSCGTQTEVPLEV 650
                    :|:.:.|::.|     .||:|..|:  .:.||:|.|:...|:               
Human   328 --------EEENEELRQRL-----IETELAKQV--LQTELERPREHSLKK--------------- 362

  Fly   651 VAFPRGTQTVATVQSDMSTSVENLVTSNVAVTQTDF-------------EVPDRNVSIERETMSS 702
                |||:::.  ::|..|.|:.  .|.....|..|             ::...|.|::.|.:. 
Human   363 ----RGTRSLG--KADKKTLVQE--DSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLK- 418

  Fly   703 PFAGLFPPSSSSRVGQSGSLLFPSAISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDP 767
             :..|:           |.|  .||:|       ..:|:..||...                   
Human   419 -YRSLY-----------GDL--DSALS-------AEELADAPHSRE------------------- 443

  Fly   768 AELRILLELNEQEASILRLKVEDLEKENAESKKYVRELQAKLRQDSSNG-------SKSSLLSLG 825
            .||::.|:|.|:||::|..::.:||.||       |.|:|::.....:|       ::.:..:||
Human   444 TELKVHLKLVEEEANLLSRRIVELEVEN-------RGLRAEMDDMKDHGGGCGGPEARLAFSALG 501

  Fly   826 ---TSSSAAE--KKVKTLNEELVQLRRTLTEKEQTVDSLKNQLSKLDTLETENDKLAKENKRLLA 885
               ...|.||  :.::.:.||...|||:..|.|.....|.|:|:|..: |.|.|....|      
Human   502 GGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRS-EHELDVALSE------ 559

  Fly   886 LRKASEKTGEVDQKMKESLAQAQRERDELTARLKRMQLEAEDKLPPRTAKRVNDLTPKSHLKKWV 950
                 :....:.:..:|.||.|:.:..||:.::|::|.                           
Human   560 -----DSCSVLSEPSQEELAAAKLQIGELSGKVKKLQY--------------------------- 592

  Fly   951 EELEDEISEMRVMLSSSGTDQLKALQSAKGALEED----------------------LRKCKQKL 993
                    |.||:||:.....|.:.||.:..||.|                      :|.|:.: 
Human   593 --------ENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAR- 648

  Fly   994 SLAEGDVQRLKLLNGSSSKVSELEQKLKRGDEEAKKLNSKLKDLEDKVKKQEAQLKLGETSKSTW 1058
               |.:|  |..|...::.||      |..|......|.....|...:..:.|..:|.|...:  
Human   649 ---EAEV--LPGLREQAALVS------KAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDN-- 700

  Fly  1059 ESQSKREKEKLSSLEKDMEKQAKEKEKLEAKISQLDAELLSAKKSAEKSKSS--------LEKEI 1115
             |:..|:.:.:.::   :.:.:..:::|.|...:.||.|..:.|..::|.||        |.|||
Human   701 -SEGPRDTKLIHAI---LVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEI 761

  Fly  1116 ---KDLKTKASKSDSKQVQDLKKQVEEVQASLSAEQKRYEDLNNHWEKLSEETILMRAQLTTEKQ 1177
               |||.:.....|.:.:.:.:.::.|.        .|..||::            :...:...:
Human   762 LLAKDLGSDFQPPDFRDLPEWEPRIREA--------FRTGDLDS------------KPDPSRSFR 806

  Fly  1178 SLQAELNAS-KQKIAEMDTIRIERTDMARKLSEAQKRIADLQAKALKTVNGNGAEYERTVLKNKL 1241
            ..:||.|.| ..:|.|:..:          |:||...:..||                       
Human   807 PYRAEDNDSYASEIKELQLV----------LAEAHDSLRGLQ----------------------- 838

  Fly  1242 AEKEHEYERLRRENEMNIDLVFQLRKDN-DDLNGKLSDYNRIEQAQSSLNGHGARREAEIRELKE 1305
                   |:|.:|.        ||||:. |:.|.|:....  |..|.:|    .|||.|      
Human   839 -------EQLSQER--------QLRKEEADNFNQKMVQLK--EDQQRAL----LRREFE------ 876

  Fly  1306 QLQSTELQMKSEVATVRLRYEQQVKNLSGELTSMQRQCERFKKDRDAFKQMLEVAQKKIGDLKAN 1370
             |||..||.:.|     .::..|.||:      :.::.::||.:      .|.:..|....||  
Human   877 -LQSLSLQRRLE-----QKFWSQEKNM------LVQESQQFKHN------FLLLFMKLRWFLK-- 921

  Fly  1371 NTGRQSRGSMHSSDDDDKSKIAYLEQQIGHLEDQLVESRLESSKIKT-ELVSERSANE-IK-ISE 1432
               |..:|.:..|:.||..::..:::....:|::.:.::...:|..| :..::.:.|| || :::
Human   922 ---RWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLAD 983

  Fly  1433 MQSKLNE----FEEERVIGSGSTKLPGMKTKLELSW----------------------------- 1464
            |:..|.|    ..:||   .|.|:|.....|.:.:|                             
Human   984 MKVTLKELCWLLRDER---RGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPD 1045

  Fly  1465 -----QKEREDQQRLLQETSTLARDLRQTLFEVERERDKERLESKRKLDQIKRATEEEMEEGRKK 1524
                 |:|||:||.||.|:.:...:|.:.|...||...:|:|:...:|...|:..|::::|.:.:
Human  1046 WKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNR 1110

  Fly  1525 IAELQ--CDLLELRDVHAKLRTSNEKLRRERERYEKELIKRRMEADGGDRKVGALLQTVDE---L 1584
            :::||  .|...|:....:.:.::.|..|..:.::||.:. .:|..|...|....:.::.|   |
Human  1111 LSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVS-EVELGGNGLKRTKSVSSMSEFESL 1174

  Fly  1585 VKIAPDLKIVGSGGSAR-----SSSSSGYDKNLRPEQPNVRRSRSPSPTLSSSQITSVLARLAEA 1644
            :..:|.|    :||.||     ::.:.|:..: .|..|  .:.....|.|||...          
Human  1175 LDCSPYL----AGGDARGKKLPNNPAFGFVSS-EPGDP--EKDTKEKPGLSSRDC---------- 1222

  Fly  1645 SEELRKFQRVNEDEQERSRMRRSNLRRAASQENDPHGSTSSVASAAGSQRGGGRLSRNSSNNGSL 1709
                                  ::|...|.|  ||.|.....:..|..:.|              
Human  1223 ----------------------NHLGALACQ--DPPGRQMQRSYTAPDKTG-------------- 1249

  Fly  1710 IRKSLSLDHSIQRDQNIWRQDDGSV---------SSMQSIDSELGGLVRDSS---LDSRLDSRLS 1762
            ||...|...:.:....:....:|.:         ::.....:|..||...|.   |.:....||.
Human  1250 IRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAEADGLAESSYGRWLCNFSRQRLD 1314

  Fly  1763 GGSTQSDIPRGPRKKKKGIMGKLRSLTKSSRNSESEISIQGSDSDISVASDMRSSKKDLRGRL-S 1826
            |||..|....||     |....|.           :..:.|:.||     ||:.....:|..: |
Human  1315 GGSAGSPSAAGP-----GFPAALH-----------DFEMSGNMSD-----DMKEITNCVRQAMRS 1358

  Fly  1827 GMFKRSGSASRSESMERAGSDQRPVAVTVVGHPDGPQPREPPPANSLTPR-----PIRS------ 1880
            |..:|...::.|:::..|....:.:....||....| ||......:.:||     .:||      
Human  1359 GSLERKVKSTSSQTVGLASVGTQTIRTVSVGLQTDP-PRSSLHGKAWSPRSSSLVSVRSKQISSS 1422

  Fly  1881 -------IPKP---PSAGAPTTPTTRRRVAK 1901
                   |.:|   |..|:|  ...||.|:|
Human  1423 LDKVHSRIERPCCSPKYGSP--KLQRRSVSK 1451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG18304NP_001260170.1 SMC_prok_B <354..1093 CDD:274008 167/807 (21%)
SMC_prok_B 831..>1544 CDD:274008 162/792 (20%)
PHA03307 1657..>1901 CDD:223039 55/277 (20%)
MTCL2NP_542194.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..187 39/195 (20%)
PRK07003 <33..>179 CDD:235906 30/159 (19%)
Required for association with Golgi apparatus membrane. /evidence=ECO:0000250|UniProtKB:E1U8D0 211..240 15/35 (43%)
SMC_prok_B 253..>550 CDD:274008 89/407 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..373 6/40 (15%)
SOGA 380..474 CDD:463264 28/141 (20%)
SOGA 508..597 CDD:463264 28/135 (21%)
GumC <1002..>1119 CDD:442439 25/116 (22%)
DUF4482 1069..1207 CDD:464333 31/143 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1196..1221 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1432..1456 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1538..1563
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1661
Blue background indicates that the domain is not in the aligned region.

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