Protein Alignment CG18304 and mtcl2

DIOPT Version :10

• Sequence 1: NP_001260170.1
• Gene: CG18304 / 33969
• FlyBaseID: FBgn0031869
• Length: 1901
• Species: Drosophila melanogaster
• Sequence 2: XP_002942331.3
• Gene: mtcl2 / 100493417
• XenbaseID: XB-GENE-6049995
• Length: 1617
• Species: Xenopus tropicalis
• Alignment Length: 2031
• Identity: 373/2031 - (18%)
• Similarity: 655/2031 - (32%)
• Gaps: 784/2031 - (38%)

  Fly   215 PRREEESESTATPTPVVPDRPERSKSGTSLNQLAQAE-QKRAALPPKKVAVASTTTASSSNSSST 278
            |...|:.:....|:|..|    :..||.||::..::. ...:.|||          .......|.
 Frog    13 PPAPEKKKMNRAPSPARP----KELSGWSLSKTRRSSPASLSVLPP----------GPRRPLPSP 63

  Fly   279 SLKTSNSTSASNEVKVVTSTSSSSTSSSSVRRKEADSVASKEIKRQTVPAASISHSNSTSSTAST 343
            ..|.........:.|.:.......|.|||     ..|.||:|                :|.|:..
 Frog    64 GTKKQPGARPGGKSKSLGGAPGPRTDSSS-----EGSCASEE----------------SSGTSRG 107

  Fly   344 ASKSQDTNGMQEQMKALKLELETMKTRAEKAEREKSDILLRRLASMDTASNRTAASEALNLQQKL 408
            ||..:...|                                     ...|:|...|.::....
 Frog   108 ASSEEGGGG-------------------------------------SGTSSRMQCSTSMAFSD-- 133

  Fly   409 NEMKEQLDRVTEDKRKLNLRMKELENKGSESELRRKLQAAEQICEELMEENQSAKKEILNLQAEM 473
                     :|||          |.:.|:|..||.        .:||..||...|.||..|::||
 Frog   134 ---------LTED----------LLDGGTEGLLRE--------MDELRSENDYLKDEIEELRSEM 171

  Fly   474 DEVQDTFRDDEVKAKTSLQKDLEKATKNCRILSFKLKKSDRK--------------IETLEQE-- 522
            .|::|.:.:::|.....|::.||:..|.||||.::|||::|:              |.||||:
 Frog   172 LEMRDVYMEEDVYQLQELRQQLEQVHKTCRILQYRLKKAERRGLRVAQTGQVDSELISTLEQDVK 236

  Fly   523 -------RQSSFNAELSNKIKKLE---EELR---FSNELTRK-LQAEAEELRNPGKKKAPMLGVL 573
                   |..|....:..|..|||   ||||   ...:|.:: ||.|.|:::....||....|.:
 Frog   237 VAKDVSVRLHSELEAVEKKRIKLEDENEELRQRLIETDLAKQVLQNEMEKMKENSLKKRRSSGRI 301

  Fly   574 GKSTSADAKFTRESLTRGGSQEDPQHLQRELQDSIERETDLKDQLKFAEEELQRLRDRERKRVRF 638
            .|..|.              |||              ..|||.||.||:||...:
 Frog   302 DKKPSL--------------QED--------------SADLKCQLHFAKEESALM---------- 328

  Fly   639 SCGTQTEVPLEVVAFPRGTQTVATVQSDMSTSVENLVTSNVAVTQTDFEVPDRNVSIERETMSSP 703
             |...|::..:............::..||                      |.::|:|
 Frog   329 -CKKLTKLAKDNDNMKEDLTKYRSMYGDM----------------------DSSLSVE------- 363

  Fly   704 FAGLFPPSSSSRVGQSGSLLFPSAISHVLLSGAGRKLSPTPHPHRLAPEVHADRDEGISDEDDPA 768
                                               :|:.:||...                   |
 Frog   364 -----------------------------------ELANSPHSRE-------------------A 374

  Fly   769 ELRILLELNEQEASILRLKVEDLEKENAESKKYVRELQAKLRQDSSNGSKSSLLSL-----GTSS 828
            ||::.|:|.|:||::|..::.:||.||...:..:.|:  |:..|....|:....:.     |.:.
 Frog   375 ELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDEM--KIHHDRELLSQDGRFAFPPGESGDNF 437

  Fly   829 SAAEKKVKTLNEELVQLRRTLTEKEQTVDSLKNQLSKLDTLETENDKLAKENKRLLALRKASEKT 893
            ....:.::.:.||...|||::.|.|.....|.|:|:|   .::::|         |.:..:.:..
 Frog   438 VELRRHLQFVEEEAELLRRSMMELEDQNKLLMNELNK---YKSDHD---------LDITLSEDSC 490

  Fly   894 GEVDQKMKESLAQAQRERDELTARLKRMQLEAEDKLPPRTAKRVNDLTPKSHLKKWVEELEDEIS 958
            ..:.:..:|.|..|:.:..||:.::|::|.
 Frog   491 SVISEPSQEELTTAKMQISELSGKVKKLQY----------------------------------- 520

  Fly   959 EMRVMLSSSGTDQLKALQSAKGALEEDLR-----KCKQKLSLAEGDVQRLKLLNGSSSKVSELEQ 1018
            |.||:||:.....|.:.|:.:..:|.|..     :|.......||.:       |..:..::.::
 Frog   521 ENRVLLSNLQRYDLASCQATRPLMETDAEAGDSAQCVPSPLWREGPI-------GGETDAADSKE 578

  Fly  1019 KLKRGDEEAKKLN----SKLKDLEDKVKKQEAQLKLGETSKSTWESQSKREKEKLSSLEKDMEKQ 1079
            :..:|:..:..::    |||      :|.:|.:..||.|:::...|::
 Frog   579 QEGKGNTRSPNVSHSSPSKL------IKVKELETLLGITTQAGLISKA----------------- 620

  Fly  1080 AKEKEKLEAKISQLDAELLSAKKSAEKS--KSSLEKEIKDLKTKASKSDSKQVQDLKKQVEEVQA 1142
                           .|:|.:..:...|  |...:.:..||....:..:|:...| .|.:..:.:
 Frog   621 ---------------IEVLKSDYNGFPSGVKLRTDNDCGDLLLTEAIDNSEMTSD-SKLIGAIFS 669

  Fly  1143 SLSAEQKRYEDLNNHWEKLSEETILMRAQLTTEKQSLQAELNASKQKIAEMDTIRIERTDMARKL 1207
            .|:.                                ||.|||...:|:..:.....|:.|.:..|
 Frog   670 RLAV--------------------------------LQQELNCFTKKVDALGACCKEQMDSSASL 702

  Fly  1208 SEAQKRIADLQAKALKTVNGNGAEYERTVLKNKLAEKEH-------EYERLRRENE--------- 1256
            .||..                      |......:.|||       |...||::.|
 Frog   703 PEAAS----------------------TDTSKDSSRKEHCSNVQQPECRNLRQKEEPCTEKQDGD 745

  Fly  1257 MNIDLVFQLR-------KDNDDLNGKLSDYNRI-EQAQSSLNG--HGARREAEIR---------- 1301
            .|.|   |.|       :|||....::.|...: .:|..|:.|  ....:|.|:|
 Frog   746 HNCD---QTRSYKTYQPEDNDSYAAEIKDLQLVLSEANESIQGLQEQLSQERELRKEDKMAYNQK 807

  Fly  1302 --ELKEQLQSTELQMKSEVATVRLRYEQQVKNLSGELTSMQRQCERFKKD--------------- 1349
              :|||..:...|:.:.|:.::.|:...:.|..|.|...:.::..:||::
 Frog   808 IAQLKEDQEKLLLRREFELQSLGLQRRLEQKFWSQEKNVLVQETHQFKQNFLLLFMKLKWYLQHW 872

  Fly  1350 -------RDAFKQMLEVAQKK--------------IGDLKAN-------NTGRQSRGSMHSSDDD 1386
                   ||.  ..|||...|              |.|.|.:       |..|:|
 Frog   873 RQGKALPRDG--DFLEVNSVKELYMLIEEEELNPPISDYKVSDGESWPQNVARES---------- 925

  Fly  1387 DKSKIAYLEQQIGHLEDQLVESRLESSKIKTELVSERSANEIKISEMQSKLNEFEEERVIGSGST 1451
             ...|:.::..:..|.::|.|.|...::::.:....::|.|::  .|:.||:         ||..
 Frog   926 -MKTISDIKGTLKDLCNELQEERRGMNELQQQFAKAKAAWEME--RMEFKLD---------SGKH 978

  Fly  1452 KLPGMKTKLELSWQKEREDQQRLLQETSTLARDLRQTLFEVERERDKERLESKRKLDQIKRATEE 1516
            .:....:.|:.:.::|||:.|.||.|:.:...||.:.|...|:...:|:.|...:....::..::
 Frog   979 GVDRASSDLKSALKREREEHQHLLAESYSAVMDLTKQLQVNEKNWAQEKEELLNRFQDERKLADQ 1043

  Fly  1517 EMEEGRKKIAELQCDLLELRDVHAKLRTSNEKLRRERERYE---KELIKRRMEAD--------GG 1570
            :|.|.:||:.:.:.|               ..:::|.||..   ||.:..:::..        ..
 Frog  1044 QMRELQKKLKQKEAD---------------SWVKKEPERRSSCWKEAVSNKLQDKDIDCDCDCDS 1093

  Fly  1571 DRKVGALLQT--------VDELVKIAP-----------------------DLKIVGSGGSARSSS 1604
            |..|.:|.:|        .:.|:..:|                       .|.:.||..|.:..|
 Frog  1094 DASVTSLKRTKSVSSMSEFESLLDCSPFLHDNTSSANGENANERRGLPASTLLVNGSKNSEKHCS 1158

  Fly  1605 SSGYDKNL------------------------------------RPEQPNVRRSRSPS------- 1626
            ..|.|.:|                                    .|::..:|...||.
 Frog  1159 YEGNDNSLAGHLPKGNLVISSWDYTMAKADNRVDGQKHIQRSYTAPDKTGIRIYYSPPVVRRLDV 1223

  Fly  1627 PTLSSSQ-----ITSVLARLAEASE-----------------ELRKFQR---------------- 1653
            |.:.:.:     .|..|..:|:..|                 ...|.||
 Frog  1224 PLVQNKEDKLMVETGFLFTMAKPKESEKSDGLSGNSYSRWLCNFSKKQRDLLDGDSVKDSSSVPG 1288

  Fly  1654 -------------VNEDEQE-----RSRMRRSNLRR----AASQ-------------------EN 1677
                         :::|.:|     |..:|.|:|.|    .|||                   :.
 Frog  1289 FPSSLGDLEISGNMSDDMKEITNCVRQAIRSSSLERKPKSTASQTVGLSSVGVQTVQMVSVGLQT 1353

  Fly  1678 DPHGSTSSVASAAGSQRGGGRLSRNSSNNGSLIRKSLSLDHS---------------IQR----- 1722
            ||  :.||:.|.:.|.|....||..:.:    |..||...||               :||
 Frog  1354 DP--TRSSLTSKSWSPRSSSLLSTRTKH----ISTSLDKVHSRIDRPCCSPKYGSPKLQRRLSSK 1412

  Fly  1723 -----DQNIW----RQDDGS--VSSMQSIDSELGGLVRD--SSLDSRLDSRLSGGSTQSDIPRG- 1773
                 |:::|    .:.:||  ..|..:.||.:...:.|  |||.:.:|   ..|||:|....|
 Frog  1413 LDGSKDRSLWNLHQNKQNGSAWARSTTTRDSPVLSNINDGSSSLFNVVD---HAGSTESICRLGL 1474

  Fly  1774 --PRKK----KKGIMGK-LRSLTKSSRNSESEISIQGSDSDISVASDMRS--------------- 1816
              .|.|    |.||:.: .|::...:..|.|.:|.:....|.:...|...
 Frog  1475 GESRSKSDTPKYGIVQEFFRNVCGRTSQSSSAVSEKKEAEDCNKRPDNHDHCSSVCHSTYNVSKL 1539

  Fly  1817 -SKKDLRGRLSGMFKRSGSASRSESMERAGSD-------QRPVAVTVVGHPDGPQPREPPPANSL 1873
             |||..|...|.  ::.||...||.:..:.::       .:|: .:....|..||.|:......|
 Frog  1540 LSKKVPRQHTSD--EQKGSPKDSEVIATSTNEDYACNCSSQPL-TSCFSRPSRPQSRQAQYKCQL 1601

  Fly  1874 TPRPIRSIPKPPSAGA 1889
            .|.|  ::|:..:..|
 Frog  1602 HPDP--TVPEDKAGPA 1615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18304	NP_001260170.1	SMC_prok_B	<354..1093	CDD:274008	144/782 (18%)
		SMC_prok_B	831..>1544	CDD:274008	140/804 (17%)
		PHA03307	1657..>1901	CDD:223039	73/325 (22%)
mtcl2	XP_002942331.3	SMC_prok_B	185..>477	CDD:274008	88/418 (21%)
		SOGA	310..404	CDD:463264	33/201 (16%)
		SOGA	439..525	CDD:463264	22/132 (17%)
		GumC	<929..>1059	CDD:442439	31/155 (20%)
		DUF4482	1010..>1120	CDD:464333	21/124 (17%)