Protein Alignment Rat1 and XRN1

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: NP_011342.1
• Gene: XRN1 / 852702
• SGDID: S000003141
• Length: 1528
• Species: Saccharomyces cerevisiae
• Alignment Length: 854
• Identity: 289/854 - (33%)
• Similarity: 411/854 - (48%)
• Gaps: 213/854 - (24%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||:|.|||::|.::|.::               .:.|...:|     ||||||||||.|:|.|||
Yeast     1 MGIPKFFRYISERWPMIL---------------QLIEGTQIP-----EFDNLYLDMNSILHNCTH 45

  Fly    66 PEDKPAPK--NEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTE 128
            ..|....|  .|:|:...|...||.||..::|:|:.|||||||||||||||||:||||.|.: .|
Yeast    46 GNDDDVTKRLTEEEVFAKICTYIDHLFQTIKPKKIFYMAIDGVAPRAKMNQQRARRFRTAMD-AE 109

  Fly   129 KRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGI 193
            |.|:.|      :..|.::|    |||.||||.|||||.||.:|:|.|.||:||:.:|:..|:.:
Yeast   110 KALKKA------IENGDEIP----KGEPFDSNSITPGTEFMAKLTKNLQYFIHDKISNDSKWREV 164

  Fly   194 KVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFL 258
            ::|.|...||||||||||::||..::|.|.:.||:|.:.|.|||||||||:||.|:|.::|||..
Yeast   165 QIIFSGHEVPGEGEHKIMNFIRHLKSQKDFNQNTRHCIYGLDADLIMLGLSTHGPHFALLREEVT 229

  Fly   259 PNKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQTLEM-- 321
                        ||....:...|                 ....|..:.||:||||::  ||.
Yeast   230 ------------FGRRNSEKKSL-----------------EHQNFYLLHLSLLREYME--LEFKE 263

  Fly   322 --PNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSG 384
              ..:.|||:|||.|||::.:.|.:||||||:||.|.:.:||...|::.:|:.:..|.||:.:.|
Yeast   264 IADEMQFEYNFERILDDFILVMFVIGNDFLPNLPDLHLNKGAFPVLLQTFKEALLHTDGYINEHG 328

  Fly   385 DVNLDRVQLIMTDLGNAEDQIFKSRQRREEQFKAR------DKARKRQ----------------- 426
            .:||.|:.:.:..|...|...|:......|.|..:      :..||||
Yeast   329 KINLKRLGVWLNYLSQFELLNFEKDDIDVEWFNKQLENISLEGERKRQRVGKKLLVKQQKKLIGS 393

  Fly   427 ------ERNQDHGS-------------------------LNQSAFGASAVGPNSQQRSVGNYKEE 460
                  |:.|:..|                         |.:.||.......:|  :|.|:|
Yeast   394 IKPWLMEQLQEKLSPDLPDEEIPTLELPKDLDMKDHLEFLKEFAFDLGLFITHS--KSKGSY--- 453

  Fly   461 AAALRNRKRTSDMANLDD-------------------------EDEEENNDEVRLWEDGF---KD 497
                 :.|...|..|.|:                         ||:||...|..::.:.|   |.
Yeast   454 -----SLKMDLDSINPDETEEEFQNRVNSIRKTIKKYQNAIIVEDKEELETEKTIYNERFERWKH 513

  Fly   498 RYYESKFDVAPGNQQFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLST 562
            .||..|......:::....:|..||.||.|||.|||:||.||:||:|:||||..||..  :||..
Yeast   514 EYYHDKLKFTTDSEEKVRDLAKDYVEGLQWVLYYYYRGCPSWSWYYPHHYAPRISDLA--KGLDQ 576

  Fly   563 MFEKG-TKPFNPLEQLMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKKFAWQGV 626
            ..|.. :|||.|.:|||.|.|..|.:.:|..:..||.|.:|||.||||.:.::|.|||...|:.|
Yeast   577 DIEFDLSKPFTPFQQLMAVLPERSKNLIPPAFRPLMYDEQSPIHDFYPAEVQLDKNGKTADWEAV 641

  Fly   627 ALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYLYISNQSPHYKKVKKISEKDDESVCKAIS 691
            .|:.|||||||.:|:.||..:|:.||..||:.|.:.:|                          |
Yeast   642 VLISFVDEKRLIEAMQPYLRKLSPEEKTRNQFGKDLIY--------------------------S 680

  Fly   692 FDGMRGTLGKTELNTAISGVLKSPISGL-SDINDNITVTTTFRDPEYDEDYIFEAKRLENAVDPP 755
            |            |..:..:.|||:.|: |||..|..|         :::||  ...|:::....
Yeast   681 F------------NPQVDNLYKSPLGGIFSDIEHNHCV---------EKEYI--TIPLDSSEIRY 722

  Fly   756 QVLPNEQSG 764
            .:|||.:.|
Yeast   723 GLLPNAKLG 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	282/823 (34%)
XRN1	NP_011342.1	XRN1	1..955	CDD:227382	289/854 (34%)
		XRN1_D2_D3	918..1005	CDD:436419
		Xrn1_D3	1087..1156	CDD:465674
		SH3_12	1163..1233	CDD:465661