Protein Alignment Rat1 and exo2

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: NP_593482.1
• Gene: exo2 / 2542204
• PomBaseID: SPAC17A5.14
• Length: 1328
• Species: Schizosaccharomyces pombe
• Alignment Length: 730
• Identity: 285/730 - (39%)
• Similarity: 388/730 - (53%)
• Gaps: 148/730 - (20%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||:|.||||:|.:||.    |::           :.|:..:|     ||||||||||||:|.|||
pombe     1 MGIPKFFRWMSERYPL----CSQ-----------LIENDRIP-----EFDNLYLDMNGILHNCTH 45

  Fly    66 PED--KPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTE 128
            ..|  ...|..|:||.:|||..|:.||..::|:||||||:||.|||||||||||||||.||:..:
pombe    46 KNDDHSSPPLPEEEMYIAIFNYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRFRTAKDAHD 110

  Fly   129 KRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGI 193
            .||:..|..|:.        ||    |.||||||||||.||:|:|:.|:||:|.:..|:..|:.|
pombe   111 ARLKAERNGEDF--------PE----EQFDSNCITPGTTFMERVSRQLYYFIHKKVTNDSQWQNI 163

  Fly   194 KVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFL 258
            :||.|..:.|||||||||:|||.|:|||.::|||:|.|.|.|||||||||.:|:|:|.::|||..
pombe   164 EVIFSGHDCPGEGEHKIMEYIRTQKAQPSYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVT 228

  Fly   259 PNKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQTLE--M 321
                        ||             |.|.|...::   |..||..:.||:|||||:...:  .
pombe   229 ------------FG-------------PASRNRSKEL---AHQKFYLLHLSLLREYLEFEFQECR 265

  Fly   322 PNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGDV 386
            ....|:|..|:.|||::.:.||||||||||||.|.|.|||:..:..:|||.:....||:.:.|.:
pombe   266 STFTFKYDLEKILDDFILLAFFVGNDFLPHLPGLHINEGALALMFSIYKKVMPSAGGYINEKGVI 330

  Fly   387 NLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDKARKRQERNQDHGSLNQSAFGASAVGPNSQQ 451
            |:.|::||:.:|.|.|.:|||:           :.:..:...|.|..|.:...:...:.  |..:
pombe   331 NMARLELILLELENFEKEIFKA-----------EVSETKNNGNSDKPSFDFLKYITEST--NDIK 382

  Fly   452 RSVGNYKEEAAALRN-----------------------RKRTSDM-------------------- 473
            ...|..|.....::.                       |:..:|:
pombe   383 AMTGEQKNYFLQIKKFLSSREPFIDFSANISSVDQRFLRRLCNDLHLSFSKIIKVDGTHLLRITF 447

  Fly   474 --ANLDDEDEEE------------------NNDEVRLWEDG-------FKDRYYESKFDVAPGNQ 511
              ...:||||:|                  .|:|..|.|..       :||.||.||...:..::
pombe   448 RDLEFNDEDEDEIEQDEIERVLQKYDNIPLLNEEQALKEKNVEKDFIQWKDDYYRSKVGFSYYDE 512

  Fly   512 QFRYAVALQYVRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQ 576
            :...|:|.:||.||.|||.|||:||.||.||:.||:||..||.:....:...|:.|| ||.|.||
pombe   513 EALKAMAERYVEGLQWVLFYYYRGCQSWGWYYNYHFAPKISDVLKGLDVKIDFKMGT-PFRPFEQ 576

  Fly   577 LMGVFPAASSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKAL 641
            ||.|.||.|.:.||..:..||.:.||||||||||:|.:|.|||..:|:.|.::||:||.||..||
pombe   577 LMAVLPARSQALVPPCFRDLMVNSESPIIDFYPENFALDQNGKTASWEAVVIIPFIDETRLIDAL 641

  Fly   642 VPYYDQLTGEEVKRN 656
            ......||.||.|||
pombe   642 ASKDKFLTEEERKRN 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	285/730 (39%)
exo2	NP_593482.1	XRN1	1..932	CDD:227382	285/730 (39%)
		XRN1_D2_D3	895..980	CDD:436419
		Xrn1_D3	1060..1125	CDD:465674
		SH3_12	1133..1199	CDD:465661