Protein Alignment Rat1 and xrn-2

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: NP_496958.2
• Gene: xrn-2 / 175071
• WormBaseID: WBGene00006964
• Length: 975
• Species: Caenorhabditis elegans
• Alignment Length: 989
• Identity: 483/989 - (48%)
• Similarity: 609/989 - (61%)
• Gaps: 97/989 - (9%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||||||||::|||:.::..||::|.|.| |..:..|.|.||||..||||||||||||||||||
 Worm     1 MGVPAFFRWLTKKYPATVVNANEDRQRDQD-GNRVPVDCTQPNPNFQEFDNLYLDMNGIIHPCTH 64

  Fly    66 PEDKPAPKNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTEKR 130
            |||:|||||||||...|||.|||::.|||||:|||||||||||||||||||||||||:||..||.
 Worm    65 PEDRPAPKNEDEMFALIFEYIDRIYSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEMAEKE 129

  Fly   131 LEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGIKV 195
            ..|...|..|::.|..:||:|::..||||||||||||||.||:..|.|::|||..|:.:|..|::
 Worm   130 ASIEEQRNRLMAEGIAVPPKKKEEAHFDSNCITPGTPFMARLADALRYYIHDRVTNDASWANIEI 194

  Fly   196 ILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFLPN 260
            ||||||||||||||||||:||||..|.|||||.|.||||||||||||:||||.||.||||||:||
 Worm   195 ILSDANVPGEGEHKIMDYVRKQRGNPAHDPNTVHCLCGADADLIMLGIATHEANFNIIREEFVPN 259

  Fly   261 KPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDV--PIGAEVKFIFVRLSVLREYLKQTLEMPN 323
            :||.||:|..:|||:.:|.|    |....:...|.  |...|..|||:|:.||||||::.|.|||
 Worm   260 QPRACDLCGQYGHELKECRG----AENETDLGDDYCKPEQREKNFIFLRIPVLREYLEKELSMPN 320

  Fly   324 LPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGDVNL 388
            |||::..|||||||||:|||||||||||||||||||||:|||::|||:.||:.:||||..|...|
 Worm   321 LPFKFDVERALDDWVFLCFFVGNDFLPHLPSLEIREGAIDRLIKLYKEMVYQMKGYLTKDGIPEL 385

  Fly   389 DRVQLIMTDLGNAEDQIFKSRQRREEQFKARDKARK----------RQERNQDHGSLNQSAF--- 440
            |||::||..||..||:|||.||:.||:|:...:.:|          |..|.:..|...|.||
 Worm   386 DRVEMIMKGLGRVEDEIFKRRQQDEERFQENQRNKKARMQMYGGGGRGGRGRGRGRGQQPAFVPT 450

  Fly   441 --------------GASAVGPNSQQR-------------SVGNYK--------EEAAALRNRKRT 470
                          |.|.....|:.|             :..|.|        |..|.:.:|||.
 Worm   451 HGILAPMAAPMHHSGESTRQMASEARQTAMKFTNDANETAAANLKALLNVKGEESPADIASRKRK 515

  Fly   471 SDMANLDDEDEEEN--NDEVRLWEDGFKDRYYESKFDVAPGNQQFRYAVALQYVRGLCWVLKYYY 533
            ::...:..|:||:.  .|::||:|.|:|||||.:||||...:.:||:.||..||.||||||:|||
 Worm   516 AEQPLIKPEEEEDEGPKDDIRLYESGWKDRYYRAKFDVGSDDIEFRHRVAWAYVEGLCWVLRYYY 580

  Fly   534 QGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAASSSHVPEPWAKLMS 598
            ||||||:||||||||||||||..:......|.:.|||||||||||.||||||..|:|..|.|||.
 Worm   581 QGCASWDWYFPYHYAPFASDFETVGEFQPDFTRPTKPFNPLEQLMSVFPAASKQHLPVEWQKLMI 645

  Fly   599 DPESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKALVPYYDQLTGEEVKRNKRGDNYL 663
            ..:|||||.||.||:|||||||:|||||||||||||.||...|...|..||.||.:||.||.|.:
 Worm   646 QDDSPIIDLYPADFRIDLNGKKYAWQGVALLPFVDETRLLATLQSVYPTLTAEEKQRNTRGPNRI 710

  Fly   664 YISNQSPHYKKVKKISE-KDDESV-CKAISFDGMRGTLGKTELNTAISGVLKSPIS--GLSDIND 724
            :|......::..::::| |.|:.| ......:|:.|.:......||......||::  ...|:..
 Worm   711 FIGRNHKSFEFFQQVAESKSDDLVPLDPTLLNGVSGKIAYDSTATAPGLPFVSPVNHDECQDLPT 775

  Fly   725 NITVTTTFRDPEYDEDYIFEAKRLENAVDPPQVLP----NEQSGNKHRPVIGFNSHLTRAYVPDS 785
            |..:...:.||||.:||||.|.||:.|.:|.:.|.    |::...:::|.:|||.:..|..:..|
 Worm   776 NCGICVLYEDPEYPQDYIFPALRLDGAKEPEKTLKPDDWNDRRDGRYQPQVGFNRNAPRGSLDQS 840

  Fly   786 GHRMLNAGIRNQQGGG------------GNGGGGGGYGQGGGYGQGIGGNQGQSYQNNSRNYNYN 838
            |||.::..:|...|||            |.|||||||.....:|:..||..|    ...:.|:..
 Worm   841 GHRQVHHYVRGGGGGGGGYRGNSYDDRRGGGGGGGGYNDRQDFGRNYGGRDG----GGPQRYHDQ 901

  Fly   839 YNNNYNQHQGGGYQNNYNNRQQQQYG-----HNQRFNQDNSNQQQRNFNNYNGPRNNNYQQQ--- 895
            .......:|||||...|........|     ::|.:|||     ||......|.....||:.
 Worm   902 QQQRQGGYQGGGYGGGYGGGGGGGGGGGGGSYHQPYNQD-----QRRGGRGGGGGPPGYQRPPYR 961

  Fly   896 ---GGSRQQNQNYR 906
               ||....|.::|
 Worm   962 GGGGGGYHGNSSWR 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	422/789 (53%)
xrn-2	NP_496958.2	XRN1	1..848	CDD:227382	446/851 (52%)