Protein Alignment Rat1 and xrn-1

DIOPT Version :10

• Sequence 1: NP_609082.1
• Gene: Rat1 / 33964
• FlyBaseID: FBgn0031868
• Length: 908
• Species: Drosophila melanogaster
• Sequence 2: NP_496945.3
• Gene: xrn-1 / 175059
• WormBaseID: WBGene00012730
• Length: 1591
• Species: Caenorhabditis elegans
• Alignment Length: 736
• Identity: 280/736 - (38%)
• Similarity: 380/736 - (51%)
• Gaps: 131/736 - (17%)

  Fly     1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGIIHPCTH 65
            ||||.|:||.|.:||.:....||::               :|     ||||||||||||||.|:|
 Worm     1 MGVPKFYRWTSERYPCLSEVINESQ---------------IP-----EFDNLYLDMNGIIHNCSH 45

  Fly    66 PEDKPAP--KNEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSRRFRAAKETTE 128
            |.|....  ..|||:.|.||..|:.|:.::||:|:.:||:|||||||||||||:|||.:|: |..
 Worm    46 PNDDDVTFRITEDEIFVNIFAYIENLYNLIRPQKVFFMAVDGVAPRAKMNQQRARRFMSAR-TAH 109

  Fly   129 KRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHYFVHDRQNNNPAWKGI 193
            .:|..|      |..|..:|.|    ..||||||||||.||.||.:.|..::..:...:..|:|.
 Worm   110 TQLAKA------LENGEIMPSE----ARFDSNCITPGTYFMTRLHQKLDDWIKTKSATDSRWQGR 164

  Fly   194 KVILSDANVPGEGEHKIMDYIRKQRAQPDHDPNTQHVLCGADADLIMLGLATHEPNFTIIREEFL 258
            |:|||..||||||||||||:||.:||...:||||:|.:.|.||||||||:.:|||:|:::|||..
 Worm   165 KIILSGHNVPGEGEHKIMDFIRTERAGSSYDPNTRHCMYGLDADLIMLGIVSHEPHFSLLREEVT 229

  Fly   259 PN-KPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIGAEVKFIFVRLSVLREYLKQTLE-- 320
            .| :||..|                    ..|..||........||..:.||:|||||.....
 Worm   230 FNTRPRKND--------------------NKATKKPKRTDSDVKKFHLLHLSLLREYLAWEFADV 274

  Fly   321 MPNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLEIREGAVDRLVELYKKCVYKTRGYLTDSGD 385
            ..:|||||..||.:|||:.:...||||||||||::.|.:.|:..|...|||.:....||:.::|.
 Worm   275 KDSLPFEYEMERIVDDWILLGLLVGNDFLPHLPNIHIHDDALPLLYSTYKKVLPTLDGYINEAGY 339

  Fly   386 VNLDRVQLIMTDLGNAEDQIFKSRQRREEQFKARDKARKRQERNQDHGSLNQSAFGASAVGPNSQ 450
            :||.|.:..:.:|...:...|..| ..:|||....:.|......|:.......||.:|.|
 Worm   340 LNLSRFEAFLAELALNDKTSFMER-LEDEQFMESKRIRVVDPEQQELAEPELVAFESSDV----- 398

  Fly   451 QRSVGNYKEEAAALRNRKRTSDMANLDDEDE-------EENNDEV----------------RLWE 492
                   ::||.|..::.........||||:       ||:.|::                :|.|
 Worm   399 -------EDEAGAEESKDEAGGAGAEDDEDDAAFVSDHEEDGDDLEPGSGSDELLLSNLDAQLLE 456

  Fly   493 DGFKDR------------------------------------YYESKFDVAPGNQQFRYAVALQY 521
            |.|.|.                                    ||..|......::|.....|..|
 Worm   457 DEFNDELATLALSGMNDADFANDVEACWTKTINNQFKRHKKTYYSDKLRYKNISKQQLREQAEGY 521

  Fly   522 VRGLCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAASS 586
            ||.:.|.|.|||.||.||:|::|:|||||.||.....|:...||. ::||:|.|||:.|.|.||:
 Worm   522 VRAIQWNLHYYYHGCVSWSWFYPHHYAPFISDVRGFVGMRMEFEL-SEPFHPFEQLLAVLPEASA 585

  Fly   587 SHVPEPWAKLM-SDP-ESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKALVPYYDQLT 649
            ..:|.|..:|| ||| :|||.||||.:|:.|||||:..|:.|.|:||::||||.:|:.....:||
 Worm   586 DCLPRPLRELMSSDPAKSPICDFYPANFETDLNGKRNEWEAVVLIPFIEEKRLLEAIEAKRSRLT 650

  Fly   650 GEEVKRNKRGDNYLYISNQSP 670
            .||..||..|.:...||:..|
 Worm   651 SEENARNSHGSHIQCISSPEP 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rat1	NP_609082.1	XRN1	1..735	CDD:227382	280/736 (38%)
xrn-1	NP_496945.3	XRN1	1..782	CDD:227382	280/736 (38%)
		SH3_12	1179..1244	CDD:465661