Protein Alignment Aatf and AATF

DIOPT Version :10

• Sequence 1: NP_609066.1
• Gene: Aatf / 33943
• FlyBaseID: FBgn0031851
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_036270.1
• Gene: AATF / 26574
• HGNCID: 19235
• Length: 560
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 183/571 - (32%)
• Similarity: 277/571 - (48%)
• Gaps: 118/571 - (20%)

  Fly     9 PQTVAEKVSKLLAHPNESDSAEDSDFDVATGPRLVD-FEEEEYDLPDARSTDF------RKRNVK 66
            ||.:|.::.:|| :|..|::..::|.:.||..|::| |:|.|    |... ||      ||....
Human     4 PQPLALQLEQLL-NPRPSEADPEADPEEATAARVIDRFDEGE----DGEG-DFLVVGSIRKLASA 62

  Fly    67 LLSEQSDRYKGKISSRKELDDDE-----DKDDEQEVSYEE--SDEDDENLTNFKQKLNAGGAEDS 124
            .|.:...||.||.:|||..::|.     ....::|:|.||  .|||.|.|          |.|:.
Human    63 SLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEEGSGDEDSEGL----------GLEEY 117

  Fly   125 EEET--AAGHSESGEESEEIES-------------NLTDFKKKFEAGDFKYDDDEEEDDDS--EE 172
            :|:.  ||...|.|:..|..:|             :::||:|..:..|.....:||||::|  ||
Human   118 DEDDLGAAEEQECGDHRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGMEE 182

  Fly   173 EDHSQESEG--DDDDSEDDEAEDDAIKPSDVM--SKTNHQAEIQKGLAVQNQLRIWERLLELRIN 233
            .|.:::|:|  ::|.:.|..:|||.:    ||  |......|::||.||:||:.:|::|||.||.
Human   183 GDDAEDSQGESEEDRAGDRNSEDDGV----VMTFSSVKVSEEVEKGRAVKNQIALWDQLLEGRIK 243

  Fly   234 TQKFTSKANQLPAPETLTKLASE-SDELQSVLNEAQERSSKLLQQLLSLQSALHQQY-------- 289
            .||.....||||.|:.......: ..|..|.|..:.:....||:.|:.||..|..||
Human   244 LQKALLTTNQLPQPDVFPLFKDKGGPEFSSALKNSHKALKALLRSLVGLQEELLFQYPDTRYLVD 308

  Fly   290 ------------SEMKKSVKRKQPTEDSGPAVKK-----FGSVLQSNFQQMIGYRNEVLLKWDDR 337
                        ||..:.|:.|:......||.:|     :.|.:...|.....|||..|.||.|:
Human   309 GTKPNAGSEEISSEDDELVEEKKQQRRRVPAKRKLEMEDYPSFMAKRFADFTVYRNRTLQKWHDK 373

  Fly   338 TKL----LTPGAGVKRKSLQEDYDIIKKIGSALANREALVEKSQT----------PKNSQAEQQE 388
            |||    |..|.|...:|      |:.:|...|.::|.|:.::||          |:.:.....|
Human   374 TKLASGKLGKGFGAFERS------ILTQIDHILMDKERLLRRTQTKRSVYRVLGKPEPAAQPVPE 432

  Fly   389 NTPVQ-----------RLK----HIYDDSDFYHQQLRELIEYKASTSSNMSEIT--KQFVELQKL 436
            :.|.:           .||    .|:||.|||||.||||||.|.|:.....::.  :|::.:|||
Human   433 SLPGEPEILPQAPANAHLKDLDEEIFDDDDFYHQLLRELIERKTSSLDPNDQVAMGRQWLAIQKL 497

  Fly   437 RQKMKKKVDTRASKGRKLRYVVHNKLINFMAPNESSDWTDASKSELYKSLF 487
            |.|:.||||.:||||||||:.|.:||::||||.:.:...|.:::|||:|||
Human   498 RSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMNDDARTELYRSLF 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aatf	NP_609066.1	AATF-Che1	210..337	CDD:463850	46/152 (30%)
		TRAUB	405..487	CDD:462388	41/83 (49%)
AATF	NP_036270.1	MSCRAMM_ClfA	<20..206	CDD:468110	58/200 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..208		41/141 (29%)
		AATF-Che1	220..373	CDD:463850	46/152 (30%)
		POLR2J binding	273..315		10/41 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..333		4/23 (17%)
		RB1 binding	316..372		15/55 (27%)
		RB1 and SP1 binding	373..472		30/104 (29%)
		TRAUB	464..548	CDD:462388	41/83 (49%)