Protein Alignment eya and eya3

DIOPT Version :10

• Sequence 1: NP_723188.1
• Gene: eya / 33916
• FlyBaseID: FBgn0000320
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: NP_001073521.1
• Gene: eya3 / 571385
• ZFINID: ZDB-GENE-060503-864
• Length: 609
• Species: Danio rerio
• Alignment Length: 715
• Identity: 249/715 - (34%)
• Similarity: 355/715 - (49%)
• Gaps: 180/715 - (25%)

  Fly   117 LPPQSQPLQPTIGSLASLSGHYSNGNA-NPNVNSSSCSLATASSFAQSA--------GSSFSTYQ 172
            ||.:.....|.:..........:|.:: :||.:.|| :.:..:|:..|:        |:...:.|
Zfish    10 LPTKKARHDPEVSQEGDSRSVVANDSSDSPNQDESS-TQSNVNSYPPSSVTHLHSIPGAPDQSNQ 73

  Fly   173 QAGGTSGGVSGEDGVVGGATVMSHWTHDG-TGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCS 236
            :....|.|...|:.          :||:. |....|..:.:....|::        .|||.
Zfish    74 ETISRSQGCVTENA----------YTHNAVTCKDLATTTSTEYTSQIY--------QGSNT---- 116

  Fly   237 SASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYY--YYNSMQQYTPPPF---YSGYGTPYAAATAA 296
                     ||...:|.||..:.    |:...|  :..|.|.|..|||   :.|..|....|.:.
Zfish   117 ---------AVTAYASQVAFPSL----GQSSMYSAFPQSGQTYGLPPFGAMWPGLKTELPEAPSV 168

  Fly   297 RQAKMEPGAAAAAAAYLTP-------SYAASGN--NNSQLYSS---------------PYAGYNN 337
            .|.    |..:.::||.:.       ||.:.|:  ..|.:|::               .:..||:
Zfish   169 GQT----GFLSFSSAYTSTQPNQILYSYPSQGSCFTTSSVYTNIPPSTAVTTAAGTHQEFTSYNS 229

  Fly   338 FGQQDYGGYYNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQT 402
            .||        .|:..||.|          |.|..|.|
Zfish   230 VGQ--------NQFSQYYVP----------PPSYMSAG--------------------------- 249

  Fly   403 THSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPTG------- 460
                   ||.:...|:|:       .|....|:.:.|.:|.....:...:...|.|||
Zfish   250 -------LPSTDRDGAGV-------VAPGYPAIKTEGSASANLPNTTDASPGVTLPTGVALPAGM 300

  Fly   461 --------------KT--GRARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHT 509
                          ||  |:|:|:. ::...::||.:|.         ||||:||||||:||||:
Zfish   301 ALPTGARDQDEQNRKTPAGKAKGKA-KKSDGSQSTDNDL---------ERVFLWDLDETIIIFHS 355

  Fly   510 LLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYN 574
            ||:||:|.::.||.::::.:..:|||::|.:||||.|||::|||||||:|||:|||||||||.||
Zfish   356 LLTGSFAQKFGKDPATVLNLGLQMEELIFELADTHLFFNDLEECDQVHVDDVASDDNGQDLSNYN 420

  Fly   575 FATDGF---HTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKRE 636
            |::|||   ...:.||:      ...|:|||:||||||||||::|:|||.|:||||.||.|.||:
Zfish   421 FSSDGFSGPSAGSGPGS------TAAVQGGVEWMRKLAFRYRRLKEIYNGYKGNVGGLLSPMKRD 479

  Fly   637 AWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIY 701
            ..|::|||||..||.|.:.|||.|.:|..|..|:|||||:|||.||||||||:|||.:|.|||||
Zfish   480 LLLRLRSEIETVTDAWLSTALKSLLLIQSRGRCMNVLVTTTQLVPALAKVLLYGLGDVFPIENIY 544

  Fly   702 SAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL 766
            ||.|||.|:|:|||::|||:|.||||||||.:||.|||..|.||||||:|.|:..|:.||::.||
Zfish   545 SATKIGKESCFERIISRFGKKVTYVVIGDGRDEEFAAKQHNMPFWRISSHGDLIFLHQALELDFL 609

  Fly   767  766
            Zfish   610  609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eya	NP_723188.1	HAD_Eya	492..766	CDD:319789	167/276 (61%)
eya3	NP_001073521.1	DUF5585	<157..>306	CDD:465521	36/211 (17%)
		HAD_Eya	338..609	CDD:319789	167/285 (59%)