Protein Alignment Kr-h1 and ZNF652

DIOPT Version :8

• Sequence 1: NP_477466.1
• Gene: Kr-h1 / 33861
• FlyBaseID: FBgn0266450
• Length: 845
• Species: Drosophila melanogaster
• Sequence 2: NP_001138837.1
• Gene: ZNF652 / 22834
• HGNCID: 29147
• Length: 606
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 140/612 (23%)
• Similarity: 231/612 (38%)
• Gaps: 148/612 (24%)

  Fly     9 KSWAPKQIWIKDVLKKSGTELLDISKSP----AKAV----AVKKSPAKDSAT---TKMVYYSANQ 62
            :|.:|..:.:.  .|.|...|.:..:.|    .:||    |||:.......|   .:.|.|...|
Human    54 ESGSPYSVLVD--TKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQ 116

  Fly    63 LLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVPPSGGQQEHFELLQTPQQRQMQLQLQDQHQQEQ 127
            ::::...::|              |.:|..|......|.:...:|:|..:.      :::..:|:
Human   117 IIVEVNLNNQ--------------TLNVSKGEKGVSSQSKETPVLKTSSEE------EEEESEEE 161

  Fly   128 QQFVSYQLAIQQHQKQQ----------QQQQHESITNAAPTAAPS-----AQRIKTEPVGGFP-- 175
            ....|......:.||::          |::...:.:.||.|.:|:     .:|...||    |
Human   162 ATDDSNDYGENEKQKKKEKIVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEP----PKR 222

  Fly   176 ---ASAAVVSQVRKPSA-SKPQFKCDQCGMTFGSKSAHTSHTK-SHSKNQ-------------DL 222
               |:....:.|:|... .|....|::|...|.::.....|.. :|.:.|             :|
Human   223 KKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESEL 287

  Fly   223 SLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAG--ADPYQCNVCQKTFAVPAR 285
            ||:..:.    ...:...:..|.:     ..|..::.....:..|  ...:.|.:|:|.|...|.
Human   288 SLHQQTD----CEKNIQCVSCNKS-----FKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAH 343

  Fly   286 LIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHT 350
            :.:|...||.:.||.||.|.|.|....:|:||...|:.|:|::|:.|...|::..:|..||.||.
Human   344 VRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHI 408

  Fly   351 GERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHC 415
            |.:...|..|.|.|........||:|||||||:.|..  |||.||....:|.|.|||||||||.|
Human   409 GHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEI--CGKSFTSRPNMKRHRRTHTGEKPYPC 471

  Fly   416 DICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVPDDEAEAAAASAA 480
            |:|.:.|.::::||.|:     .||::.|                 ...|..|..:.....:.|.
Human   472 DVCGQRFRFSNMLKAHK-----EKCFRVT-----------------SPVNVPPAVQIPLTTSPAT 514

  Fly   481 ASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQPRVSKTVAATLSIPTSSPLSPS 545
            ...|..::|.:|                  :||....|.....||           |...|.|..
Human   515 PVPSVVNTATTP------------------TPPINMNPVSTLPPR-----------PIPHPFSHL 550

  Fly   546 SLSSTYSPSASSMASPPPTSAHYLPV 571
            .:            .|.|...|:||:
Human   551 HI------------HPHPHHPHHLPI 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	4/21 (19%)
		COG5048	<270..420	CDD:227381	63/150 (42%)
		zf-C2H2	271..293	CDD:278523	6/22 (27%)
		C2H2 Zn finger	273..293	CDD:275368	6/20 (30%)
		zf-H2C2_2	286..309	CDD:290200	10/23 (43%)
		C2H2 Zn finger	301..321	CDD:275368	8/20 (40%)
		zf-H2C2_2	313..338	CDD:290200	9/25 (36%)
		C2H2 Zn finger	329..349	CDD:275368	7/20 (35%)
		zf-H2C2_2	344..366	CDD:290200	9/22 (41%)
		C2H2 Zn finger	357..377	CDD:275368	7/20 (35%)
		zf-H2C2_2	370..396	CDD:290200	15/26 (58%)
		C2H2 Zn finger	385..407	CDD:275368	10/22 (45%)
		zf-H2C2_2	400..424	CDD:290200	15/24 (63%)
		C2H2 Zn finger	415..435	CDD:275368	7/20 (35%)
		zf-C2H2	441..463	CDD:278523	1/22 (5%)
		C2H2 Zn finger	443..463	CDD:275368	1/20 (5%)
ZNF652	NP_001138837.1	UFD1	<240..304	CDD:332114	10/68 (15%)
		C2H2 Zn finger	247..266	CDD:275368	4/19 (21%)
		C2H2 Zn finger	274..293	CDD:275368	3/19 (16%)
		C2H2 Zn finger	301..321	CDD:275368	2/25 (8%)
		C2H2 Zn finger	331..351	CDD:275368	6/20 (30%)
		C2H2 Zn finger	359..379	CDD:275368	8/20 (40%)
		SFP1	<381..464	CDD:227516	35/85 (41%)
		C2H2 Zn finger	387..407	CDD:275368	7/20 (35%)
		C2H2 Zn finger	415..435	CDD:275368	7/20 (35%)
		COG5048	439..>488	CDD:227381	26/51 (51%)
		C2H2 Zn finger	443..463	CDD:275368	10/22 (45%)
		C2H2 Zn finger	471..487	CDD:275368	6/16 (38%)
		Mediates interaction with CBFA2T3. {ECO:0000269|PubMed:16966434}	498..606		19/109 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.750	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910