DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kr-h1 and Zfp384

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_038962888.1	Gene:	Zfp384 / 171018	RGDID:	708346	Length:	680	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	150/570 - (26%)
Similarity:	224/570 - (39%)	Gaps:	151/570 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTESKNDTKSWAPKQIWIKDVLKKSGTELLDISKSPAKAVAVKKSPAKDSATTKMVYYSANQLLI 65
            ||...:.::.|           ::.|::    |:.|...:.   ||:....||..   ||....|
  Rat   167 MTAGVSCSQRW-----------RREGSQ----SRGPGLVIT---SPSGSLVTTAS---SAQTFPI 210

  Fly    66 KTEQ-------SSQAQFCLQVPPPLT----ATTTSVGLG--------VPPSGGQQEHFELLQTPQ 111
            .|..       .|||   |||.|.|:    :|.|..|.|        .||           :.|:
  Rat   211 STPMIVSALPPGSQA---LQVVPDLSKKVASTLTEEGGGGGGGGGTVAPP-----------KPPR 261

  Fly   112 QRQMQLQLQDQHQQEQQQFVSYQLAIQQHQKQQQQQQHESITNAAPTAAPSAQRIKTEPVGGFPA 176
            .|:.:..|:....:....:|........|||..:..:.|.  |.......|...:.:.|
  Rat   262 GRKKKRMLESGLPEMNDPYVLAPGDDDDHQKDGKTYRSEG--NCGTGNGQSLGLMDSVP------ 318

  Fly   177 SAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAI 241
             .:..:.:..|.       |..|.:||.|||....|:|||::.:
  Rat   319 -GSTTNLLCDPG-------CRMCSLTFYSKSEMQIHSKSHTETK--------------------- 354

  Fly   242 ELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHK 306
                                        |::|..|.||||..:.|.:|.|.|:|.:|:.|.||.|
  Rat   355 ----------------------------PHKCPHCSKTFANSSYLAQHIRIHSGAKPYSCNFCEK 391

  Fly   307 LFSVKENLQVHRRIHTKE-----RPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQ 366
            .|....:||.|.|||:|.     :|:||..|.:.|.::..|.:|:|||:|.:|:.||.|:|.|.|
  Rat   392 SFRQLSHLQQHTRIHSKMHTETIKPHKCPHCSKTFANTSYLAQHLRIHSGAKPYNCSYCQKAFRQ 456

  Fly   367 SGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDF----GYNHV 427
            ...|..|.|.|||::||||..|||.|.||....|:.|.|.|..:||:.|..|.|.:    .....
  Rat   457 LSHLQQHTRIHTGDRPYKCAHPGCEKAFTQLSNLQSHRRQHNKDKPFKCHNCHRAYTDAASLEAH 521

  Fly   428 LKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVPD--DEAEAAAASAA---------- 480
            |..|.|:|  :|.|.||||...:.::..:..|::.|  ..||  .:.:||||:||
  Rat   522 LSTHTVKH--AKVYTCTICSRAYTSETYLMKHMRKH--NPPDLQQQVQAAAAAAAVAQAQAQAQA 582

  Fly   481 -------ASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQ 523
                   |...|.:.|.:.:....:|..:.....||..||..:.|..|.|
  Rat   583 QAQAQAQAQAQAQAQAQAQAQASQASQQQQQQQPPPPQPPHFQSPGAAPQ 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	9/19 (47%)
		COG5048	<270..420	CDD:227381	67/154 (44%)
		zf-C2H2	271..293	CDD:278523	9/21 (43%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	286..309	CDD:290200	10/22 (45%)
		C2H2 Zn finger	301..321	CDD:275368	9/19 (47%)
		zf-H2C2_2	313..338	CDD:290200	12/29 (41%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..396	CDD:290200	15/25 (60%)
		C2H2 Zn finger	385..407	CDD:275368	10/21 (48%)
		zf-H2C2_2	400..424	CDD:290200	9/27 (33%)
		C2H2 Zn finger	415..435	CDD:275368	6/23 (26%)
		zf-C2H2	441..463	CDD:278523	6/21 (29%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
Zfp384	XP_038962888.1	C2H2 Zn finger	330..350	CDD:275368	9/19 (47%)
		COG5048	<353..508	CDD:227381	66/203 (33%)
		C2H2 Zn finger	358..378	CDD:275368	9/19 (47%)
		C2H2 Zn finger	386..406	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..497	CDD:275368	10/21 (48%)
		C2H2 Zn finger	505..525	CDD:275368	4/19 (21%)
		C2H2 Zn finger	535..555	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000