Protein Alignment eIF4A and ddx39aa

DIOPT Version :10

• Sequence 1: NP_476595.1
• Gene: eIF4A / 33835
• FlyBaseID: FBgn0001942
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: NP_001315271.1
• Gene: ddx39aa / 325550
• ZFINID: ZDB-GENE-030131-4275
• Length: 427
• Species: Danio rerio
• Alignment Length: 417
• Identity: 152/417 - (36%)
• Similarity: 241/417 - (57%)
• Gaps: 23/417 - (5%)

  Fly     2 DDRNEIPQDGPASMEPEGVIES-----------TWHEVYDN-FDDMNLREELLRGIYGYGFEKPS 54
            |..||: .|.....||:..::|           ::..::.: |.|..|:.||||.|...|||.||
Zfish     5 DVENEL-LDYEEDEEPQPTVDSGATTGKKEVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPS 68

  Fly    55 AIQQRAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVM 119
            .:|...|...:.|.|::.||:||.||||.|.:|.||||:....:...|::..|||||.||.:...
Zfish    69 EVQHECIPQAILGMDILCQAKSGMGKTAVFVLATLQQIEPVDGQVSVLVMCHTRELAFQISKEYE 133

  Fly   120 ALGEYM-KVHSHACIGGTNVREDARILESGC-HVVVGTPGRVYDMINRKVLRTQYIKLFVLDEAD 182
            ...:|| .|......||.::::|..:|:..| |:|||||||:..:...|.|..:.:|.|||||.|
Zfish   134 RFSKYMSSVKCAVFFGGMSIKKDEDVLKKNCPHIVVGTPGRILALSRNKTLTLKNVKHFVLDECD 198

  Fly   183 EMLSR-GFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKE-ELTLEGIKQ 245
            :||.: ..:..:||:|::.|.:.|.::.|||:..::..|.|.||:||:.:.|..| :|||.|::|
Zfish   199 KMLEQLDMRRDVQDIFRLTPHEKQCMMFSATLSKEIRPVCRKFMQDPMEVFVDDETKLTLHGLQQ 263

  Fly   246 FYVNVK--QENWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDR 308
            :||.:|  ::|.|   |.||.|.|...|.|||..:..:...|:|.:...||...|:|..|.|.:|
Zfish   264 YYVKLKDSEKNRK---LFDLLDVLEFNQVVIFVKSVPRCVALSQLLVEQNFPAIAIHRGMTQEER 325

  Fly   309 EVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFI 373
            ....:||:....|:|:.|:|..||:|:::|::|.|||:|.:.:.|:||:.|.||||.||:|:.|:
Zfish   326 LSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAVTFV 390

  Fly   374 TDD-DRRILKDIEQFYHTTIEEMPANI 399
            :|: |.:||.|::..:...:.|:|..|
Zfish   391 SDETDAKILNDVQDRFEVNVAELPEEI 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_476595.1	DEAD-like_helicase_N	6..403	CDD:475120	150/413 (36%)
ddx39aa	NP_001315271.1	DEADc_DDX39	43..250	CDD:350708	80/206 (39%)
		SF2_C_DEAD	261..390	CDD:350174	50/131 (38%)