Protein Alignment CG11147 and Abcb4

DIOPT Version :10

• Sequence 1: NP_608954.1
• Gene: CG11147 / 33803
• FlyBaseID: FBgn0031734
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_032856.2
• Gene: Abcb4 / 18670
• MGIID: 97569
• Length: 1276
• Species: Mus musculus
• Alignment Length: 774
• Identity: 155/774 - (20%)
• Similarity: 282/774 - (36%)
• Gaps: 224/774 - (28%)

  Fly    13 YGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLGAKPGEPGSG 77
            |.|::|.|| |..||:.|..|....|:|.|||||:|.:..:  ||..:..|     .|....|..
Mouse   400 YPSRANIKI-LKGLNLKVKSGQTVALVGNSGCGKSTTVQLL--QRLYDPTE-----GKISIDGQD 456

  Fly    78 VPGSRVGFMPQEIALVEE------MTVKETIFYFGRIYGLTDERIREKFKLLKE------LLQLP 130
            :....|..:.:.|.:|.:      .|:.|.|     .||..:..:.|..|.:||      :::||
Mouse   457 IRNFNVRCLREIIGVVSQEPVLFSTTIAENI-----RYGRGNVTMDEIEKAVKEANAYDFIMKLP 516

  Fly   131 PARQMI-----KQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKL 190
            .....:     .|.||||::|::.|.|::.:|::|:|||.|..||.....:: ...::..|..:.
Mouse   517 QKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRT 580

  Fly   191 AVIITTHYIEEAKQANCIGLMRNGVLLAEDTPTNIMIK------------FGTQSIEDAFLI-LS 242
            .::| .|.:...:.|:.|....:||::.:.:.:.:|.|            .|:|.:.:.|.: ||
Mouse   581 TIVI-AHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLVNMQTAGSQILSEEFEVELS 644

  Fly   243 QRQGNEDEL-----AQIMDHNKNQALPA--------------AVLPP----EVIDTHEPNMP--- 281
            ..:...|..     |:|..::..::|.:              |.:||    :|:..::...|
Mouse   645 DEKAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEETNELDANVPPVSFLKVLKLNKTEWPYFV 709

  Fly   282 ----------EKQPI-------------PFEEPLNENRKKI------------FFT------TKG 305
                      ..||.             |.::.:.:.:..:            |||      |.|
Mouse   710 VGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQKCNMFSLVFLGLGVLSFFTFFLQGFTFG 774

  Fly   306 RVKALMTKN-----FVQLFRQP------------------------------------------- 322
            :...::|..     |..:.||.
Mouse   775 KAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANL 839

  Fly   323 -SGIIFMLLFPIIQLTCFYLAIGKTP-----TNLEIGVYSG-------EVENYGECFDE------ 368
             :|||...::. .|||...|::  .|     ..:|:.:.:|       |:|..|:...|
Mouse   840 GTGIIISFIYG-WQLTLLLLSV--VPFIAVAGIVEMKMLAGNAKRDKKEMEAAGKIATEAIENIR 901

  Fly   369 NLVTVYKDSDNESCLFNKL------SCRYIRVLG--DDVATRKYYASEADALNDAKRATTVGYLH 425
            .:|::.::...||....||      |.|...:.|  ..::....|.|.|............|::.
Mouse   902 TVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMR 966

  Fly   426 FAQ---NFSDSILSVMEDGIHSSDGAVDHAELSIHIDMTDQQVAY----FMQRKLRDKFS----- 478
            |..   .||..:|..:..| |:|..|.|:|:..:       ..||    |.::.|.|.:|
Mouse   967 FKDVILVFSAIVLGAVALG-HASSFAPDYAKAKL-------SAAYLFSLFERQPLIDSYSGEGLW 1023

  Fly   479 --TFMRSVVKDCNVSTAIVDLPVQFQEPIFGSTDIEFQQYCAPGVVMTMVFFLATLMTAAVFISE 541
              .|..||    ..:..:.:.|.:...|:.....:|.::    |..:.:|.......:..|.:.|
Mouse  1024 PDKFEGSV----TFNEVVFNYPTRANVPVLQGLSLEVKK----GQTLALVGSSGCGKSTVVQLLE 1080

  Fly   542 RM-DGIWDRTLLAGVSATEMLWAHLLTQLIIMALQSFEVIMYIGLVFDTYNNGDTTTLI 599
            |. |.:....||.|..|.::....|..||.|:   |.|.|::...:.:....||.:.::
Mouse  1081 RFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIV---SQEPILFDCSIAENIAYGDNSRVV 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	4..245	CDD:440746	67/261 (26%)
		ABC2_membrane_3	322..702	CDD:463674	67/363 (18%)
		YadH	513..710	CDD:440604	19/88 (22%)
Abcb4	NP_032856.2	PTZ00265	30..1269	CDD:240339	155/774 (20%)
		MdlB	39..632	CDD:440747	62/246 (25%)
		Interaction with HAX1. /evidence=ECO:0000250	622..646		5/23 (22%)