Protein Alignment CG11147 and pgp-12

DIOPT Version :10

• Sequence 1: NP_608954.1
• Gene: CG11147 / 33803
• FlyBaseID: FBgn0031734
• Length: 711
• Species: Drosophila melanogaster
• Sequence 2: NP_510126.1
• Gene: pgp-12 / 181415
• WormBaseID: WBGene00004006
• Length: 1318
• Species: Caenorhabditis elegans
• Alignment Length: 722
• Identity: 144/722 - (19%)
• Similarity: 260/722 - (36%)
• Gaps: 187/722 - (25%)

  Fly    13 YGSKSNPKIVLNQLNMNVMRGSIYGLLGASGCGKTTLLSCIVGQRRLNGGEVVVLGAKPGEPGSG 77
            |.::...| |||.||:.|..|:...|:|.|||||:|.:..:.......||:|::       .|..
 Worm   426 YPTRKKVK-VLNGLNLTVKPGTSVALVGHSGCGKSTSVGLLTRLYEPEGGKVMI-------DGQD 482

  Fly    78 VPGSRVGFMPQEIALVEEMTV--KETI---FYFGRIYGLTDERIRE-KFKLLKELLQLPP--ARQ 134
            |....:.::.:.:.:|::..:  .:||   ...|......::.||. |.....:.:|..|  ...
 Worm   483 VRSLNIDWLRKTVGIVQQEPILFNDTIHNNLLIGNPSATREDMIRVCKMANAHDFIQKMPNGYET 547

  Fly   135 MI----KQCSGGQQRRLSFACAMIHDPELLILDEPTVGLDPMLREKIWDFLVETTRNSKLAVIIT 195
            ||    .|.||||::|::.|..:|.||::|:|||.|..||......:...|....:..  ..|:.
 Worm   548 MIGDGSVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNAAKGR--TTIMI 610

  Fly   196 THYIEEAKQANCIGLMRNGVLLAEDTPTNIMI------------KF---------GTQSIEDAFL 239
            .|.:...::|:.|....|||::.......::.            ||         |.:..|:...
 Worm   611 AHRLSTIREADKIVFFENGVIVESGNHEELVALGGRYAKLVEAQKFKESDDIEDNGDEHEEETST 675

  Fly   240 ILSQRQGNEDELA--QIMDHNKNQALPAAVLPPEVIDTHEPNMPEKQPIPFEEPLNENRKKIFFT 302
            :     |..|.|:  |:..|...::|.:|.|                .|.:....|.      ||
 Worm   676 V-----GRHDRLSSRQVSFHKSCESLASADL----------------EIGYASTFNT------FT 713

  Fly   303 TKGRVKALMTKNF---VQLFRQPSGII---FMLLFPIIQLTCFYLAIGKTPTNLEIGVYSGEVEN 361
            .|...:.:..::|   ||...:..|:|   ::.:|...|....||::|.....|.....:.....
 Worm   714 LKTAQEEIENEDFAEEVQRVMEEDGVINSGYLDIFKNAQGNYLYLSVGTFFAILRGSELALLANM 778

  Fly   362 YGECFDENLVTVYKDSDNESCLFNKLSCRYIRVLGDDVATRKYYASEADALNDAKRATTVG-YLH 425
            :|..|     ..:|:.::|          .::.||  :....|.|              :| ::.
 Worm   779 FGFVF-----AAFKEPEDE----------MVKALG--LIFILYVA--------------LGLFVF 812

  Fly   426 FAQNFSDSILSVMEDGIHSSDGAVDHAELSIHI----DMTDQQVAYF-----MQRKLRDKFSTFM 481
            ..|..|.::.:::.:.:          .|...:    ::..|..::|     ...||       :
 Worm   813 ITQVISGTLFTIVAENL----------GLKFRVQSFKNLLYQDASFFDNPAHAPGKL-------I 860

  Fly   482 RSVVKDCNVSTAIVDLPVQFQEPIFGSTDIEFQQ-----YC----APGVVMTMVFFLATLMTAAV 537
            ..:..|.....|:||  .:..:.|:..|.|....     :|    ..|.:|.::|  ||:|.:..
 Worm   861 TRLASDAPNVKAVVD--TRMLQVIYSITSITINLITGYIFCWRIAIAGTIMIVLF--ATMMISMA 921

  Fly   538 FISERMDGIWDRTLLAGVSATEMLWAHLLTQLIIMA-----------------------LQSF-- 577
            :...|.:....|...||..|.|::.:....||:...                       :||.
 Worm   922 YKIARENLKQIRKDEAGKIAIEIIESVKTIQLLTSTQRFLTHYKDAQLVQHKSEMRKSYIQSVNN 986

  Fly   578 ---EVIMYIGLVFDTYNNGDTTTLIGLL----TLTAFCGMLFGLFISVFCKSHTEANFV----AT 631
               :..||..: |..|..|......|::    |..|...|:.| .::|...||....||    |.
 Worm   987 AISQTFMYFAM-FVCYGVGTPLMYHGIVEAEPTFRAINCMMMG-SVAVMHSSHNFPEFVKAKTAA 1049

  Fly   632 GAFYPMI 638
            |..:.:|
 Worm  1050 GMLFKLI 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11147	NP_608954.1	CcmA	4..245	CDD:440746	62/264 (23%)
		ABC2_membrane_3	322..702	CDD:463674	66/375 (18%)
		YadH	513..710	CDD:440604	35/171 (20%)
pgp-12	NP_510126.1	MdlB	77..654	CDD:440747	58/237 (24%)
		PTZ00265	145..1312	CDD:240339	144/722 (20%)