Protein Alignment Hsp60C and CCT5

DIOPT Version :10

• Sequence 1: NP_608948.2
• Gene: Hsp60C / 33796
• FlyBaseID: FBgn0031728
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_036205.1
• Gene: CCT5 / 22948
• HGNCID: 1618
• Length: 541
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 120/549 - (21%)
• Similarity: 213/549 - (38%)
• Gaps: 129/549 - (23%)

  Fly    37 RAMMLQGVDVL------ADAVAVTM----GPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQ 91
            |...|.|::.|      |.|||.||    ||.|.:.::....|...:|.||.|:   :::.|...
Human    24 RKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATI---LSMMDVDH 85

  Fly    92 NIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLR 156
            .| |||:.:::.:.::|.|||||...|||.|:.:|..:.:.||..|:.|..|...|.....::|.
Human    86 QI-AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLD 149

  Fly   157 RLSRPV----NTPEEICQVATISANGDKSVGNLISEAIKKVGRDGVITVKD-------------- 203
            ::|..|    ...|.:.|.|..:. |.|.| |.....:.::..:.|:||.|
Human   150 KISDSVLVDIKDTEPLIQTAKTTL-GSKVV-NSCHRQMAEIAVNAVLTVADMERRDVDFELIKVE 212

  Fly   204 GKT--LCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLL--FCEKKIKSAPSI-VPALEL 263
            ||.  ..::.::|:|:..|:.:..|......:.||:    |:|.  |...|.|:...: |.::|.
Human   213 GKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKI----AILTCPFEPPKPKTKHKLDVTSVED 273

  Fly   264 ANAQRKPLVIIAEDLEAEALSTLV--VNRLKVGLQVCAVKAPGFGDNRKENLMD----------- 315
            ..|.:|        .|.|....::  :......|.:|..   ||.|.....|:.
Human   274 YKALQK--------YEKEKFEEMIQQIKETGANLAICQW---GFDDEANHLLLQNNLPAVRWVGG 327

  Fly   316 -----MAVATGGIVFGDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLR 375
                 :|:||||.:      :.|..::.....|..|
Human   328 PEIELIAIATGGRI------VPRFSELTAEKLGFAG----------------------------- 357

  Fly   376 EAIKESTSSYEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVEEG-IVPG 439
             .::|.:....|:||.......:|....:.:.|.:.:.:.|.|..:.|||...|..:.:. :|.|
Human   358 -LVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYG 421

  Fly   440 GGTALLRC---IQKLNDLKGANEDQNM-----GIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEI 496
            ||.|.:.|   :.:..|.....|...|     .:|:|..||       ::|:|::....:.:|..
Human   422 GGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMAL-------SENSGMNPIQTMTEVRA 479

  Fly   497 -----LDGDYGYDALKGEYGNMIERGIID 520
                 ::...|.|.|.....:|.::.:|:
Human   480 RQVKEMNPALGIDCLHKGTNDMKQQHVIE 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	120/549 (22%)
CCT5	NP_036205.1	TCP1_epsilon	10..535	CDD:239455	120/549 (22%)