Protein Alignment Hsp60C and CCT6B

DIOPT Version :10

• Sequence 1: NP_608948.2
• Gene: Hsp60C / 33796
• FlyBaseID: FBgn0031728
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 129/600 - (21%)
• Similarity: 224/600 - (37%)
• Gaps: 142/600 - (23%)

  Fly    28 KDVRFGPEV-RAMMLQGVDV-----LADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIAL 86
            |.|....|| ||.....|::     |.|.:...:||||...::....|..|:||||     ::.|
Human     5 KAVNSKAEVARARAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDG-----NVLL 64

  Fly    87 KD-KFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRG------- 143
            .: :.|:..|.|:..||...::..|||||:..::...:.|:....||.|..|..|..|
Human    65 DEMQIQHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIK 129

  Fly   144 ---VMLAIETVKD-------NLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGRDG- 197
               |:..::..|:       ::.|.|.......|:..|.|          .::.:::..|.|.|
Human   130 ALEVLEEVKVTKEMKRKILLDVARTSLQTKVHAELADVLT----------EVVVDSVLAVRRPGY 184

  Fly   198 -----VITVKDGK-TLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIK-SAP 255
                 ::.:.:.| .|..:.::|:|:..|.|...|       ..|...:||.:|.|...:: ...
Human   185 PIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHP-------DMKKRVEDAFILICNVSLEYEKT 242

  Fly   256 SIVPALELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFG------------DN 308
            .:........|:.|..::.|   |.:.:...|...:.:..:|||....||.            |:
Human   243 EVNSGFFYKTAEEKEKLVKA---ERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDS 304

  Fly   309 ------------RKENLMDMAVATGGIVFGDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGK 361
                        ::.|:..:::|.||:....      .||:.:...|..|
Human   305 LAKHGIVALRRAKRRNMERLSLACGGMAVNS------FEDLTVDCLGHAG--------------- 348

  Fly   362 GQKAEVEKRVEGLREAIKESTSSYEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALN 426
                           .:.|.|...||....|......| |.|| |.|.:...:::.||.:.|.|.
Human   349 ---------------LVYEYTLGEEKFTFIEECVNPCS-VTLL-VKGPNKHTLTQVKDAIRDGLR 396

  Fly   427 ATRAAVEEG-IVPGGGTALLRCIQKL----NDLKGANEDQNMGIEIIRRALRMPCLTIAKNAGVD 486
            |.:.|:|:| :|||.|...:...:.|    |.:||.   ..:|::....||.:....:|:|||.|
Human   397 AIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGR---ARLGVQAFADALLIIPKVLAQNAGYD 458

  Fly   487 GAMVVAKVEILDGD----YGYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVT 547
            ....:.||:....:    .|.|...||.....:.|:.|...|.:          .||.:...:.|
Human   459 PQETLVKVQAEHVESKQLVGVDLNTGEPMVAADAGVWDNYCVKK----------QLLHSCTVIAT 513

  Fly   548 ELPL-EEAAAAGAAA 561
            .:.| :|...||.::
Human   514 NILLVDEIMRAGMSS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	124/584 (21%)
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	129/599 (22%)