Protein Alignment Hsp60C and CCT2

DIOPT Version :10

• Sequence 1: NP_608948.2
• Gene: Hsp60C / 33796
• FlyBaseID: FBgn0031728
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_006422.1
• Gene: CCT2 / 10576
• HGNCID: 1615
• Length: 535
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 135/580 - (23%)
• Similarity: 220/580 - (37%)
• Gaps: 157/580 - (27%)

  Fly    43 GVDVLADAVAVTMGPKGRNVIIEQSW--GSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNT 105
            |...:.|.|..|:||||.:.|:..|.  .|..:|.||.|:.|:|.:    .|..||::.|::...
Human    31 GAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGV----DNPAAKVLVDMSRVQ 91

  Fly   106 NEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRL-----SRPVNTP 165
            ::|.|||||:.||||..:.:|....|::...|..|..|...|.:..::.|...     |..|...
Human    92 DDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFR 156

  Fly   166 EEICQVA--TISA-----NGD-------------KSVGNLISEAIKKVGRDGVITVKDGKTLCDE 210
            :::..:|  |:|:     :.|             |..|||  |||.       |..|.|.:|.|.
Human   157 QDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNL--EAIH-------IIKKLGGSLADS 212

  Fly   211 LEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCE-----KKIKSAPSIVPALELANAQRKP 270
            .       .|.|::....|..::..::|  :|.:|...     .|||...|.|.....|.
Human   213 Y-------LDEGFLLDKKIGVNQPKRIE--NAKILIANTGMDTDKIKIFGSRVRVDSTAK----- 263

  Fly   271 LVIIAEDLEAEALSTLVVNRLKVGLQ--------------------VCAVKAPGFGDNRKENLMD 315
             |...|..|.|.:...|...||.|:.                    |.|::...|....:
Human   264 -VAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVER----- 322

  Fly   316 MAVATGGIVFG--DEANMVRLEDIKMSDFGRVGE--------VVVSKDDTMLLKGKGQKA--EVE 368
            :|:.|||.:..  |...:|:|...|:.:...:||        |.:.:..|::|:|..|:.  |.|
Human   323 LALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAE 387

  Fly   369 KRVEG----LREAIKESTSSYEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATR 429
            :.:..    |.:.:|:|.:.|.                    ||.|::.::.   .|....|.|
Human   388 RSLHDALCVLAQTVKDSRTVYG--------------------GGCSEMLMAH---AVTQLANRT- 428

  Fly   430 AAVEEGIVPGGGTALLRCIQKLNDLKGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKV 494
                    ||                    .:.:.:|...:||||....||.|||.|.|.:||::
Human   429 --------PG--------------------KEAVAMESYAKALRMLPTIIADNAGYDSADLVAQL 465

  Fly   495 EILDGD----YGYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELP 550
            .....:    .|.|..:|..|:|...||.:..:|.|..:..||..|.::...:.::...|
Human   466 RAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAP 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	134/576 (23%)
CCT2	NP_006422.1	TCP1_beta	11..527	CDD:239452	135/580 (23%)