Protein Alignment Hsp60C and CCT4

DIOPT Version :10

• Sequence 1: NP_608948.2
• Gene: Hsp60C / 33796
• FlyBaseID: FBgn0031728
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_006421.2
• Gene: CCT4 / 10575
• HGNCID: 1617
• Length: 539
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 130/553 - (23%)
• Similarity: 238/553 - (43%)
• Gaps: 86/553 - (15%)

  Fly    35 EVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQ 99
            ::|...:.....:|||:..::||||.:.:|:...|...||.||.|:.|.:    :..:..|:::.
Human    32 QIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQM----QVLHPAARMLV 92

  Fly   100 DVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPV-- 162
            :::...:.|||||||:..::|.::.....:.:.:|..|..|......|:|...:.|..:||||
Human    93 ELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVEL 157

  Fly   163 NTPEEICQVATISANGD--KSVGNLIS----EAIKKV----------GRDGVITVKDGKTLCDEL 211
            :..|.:...||.|.|..  ....:|:|    .|:.||          .||..|..|.|.|: |:.
Human   158 SDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTI-DDC 221

  Fly   212 EVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSI-----VPALELANAQRKPL 271
            |::||:...: .:|...|...:.||:    .|:.||    .|||..     :...:.|...|
Human   222 ELVEGLVLTQ-KVSNSGITRVEKAKI----GLIQFC----LSAPKTDMDNQIVVSDYAQMDR--- 274

  Fly   272 VIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDEANMVRLED 336
             ::.|  |...:..||....|.|..|..:        :|..|.| |::...:.|.::..::.::|
Human   275 -VLRE--ERAYILNLVKQIKKTGCNVLLI--------QKSILRD-ALSDLALHFLNKMKIMVIKD 327

  Fly   337 IKMSDFGRVGEVVVSK------DDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEKMQERLA 395
            |:..|...:.:.:.:|      ..|..:.|..:.|| |..:.|..:.:|.:..:
Human   328 IEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAE-EVNLNGSGKLLKITGCA----------- 380

  Fly   396 RLSSG-VALLRVGGSSDVEVSEKKDRVIDALNATRAAVEE-GIVPGGGT----ALLRCIQKLNDL 454
              |.| ...:.|.||:.:.:.|.:..:.|||...|..|:: .::.|||.    ..||..:....|
Human   381 --SPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTL 443

  Fly   455 KGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKV--EILDGD--YGYDALKGEYGNMIE 515
            .|.   ::..:.....|:.:...|:|:|||::....|.::  ....|:  .|.:..||...|::|
Human   444 SGM---ESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILE 505

  Fly   516 RGIIDPTKVVRTAISDAA-GVASLLTTAEAVVT 547
            ..::.|..|..:|::.|. .|.|:|...:.|.|
Human   506 ELVVQPLLVSVSALTLATETVRSILKIDDVVNT 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	130/553 (24%)
CCT4	NP_006421.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		TCP1_delta	25..538	CDD:239454	129/551 (23%)