DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grik1b

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	911	Identity:	267/911 - (29%)
Similarity:	450/911 - (49%)	Gaps:	121/911 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GLQFLVLLALA-IASGANEDTLVIKIGAIFFDTEMKLAD----AFSAALEEVN-----AINPALK 57
            |:.|::|..:| :...|.:   |::||.||...|.:...    ||..|:..:|     ..|..|.
Zfish    44 GVSFILLCLMAEVGLSAQQ---VLRIGGIFETLENEPISVEELAFKFAVTNINRNRTLMPNTTLT 105

  Fly    58 LDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDW-HPQQS 121
            .| |:| :.:.||......:||.:..||||:||||..::...|:.:||...:||:|..| ||...
Zfish   106 YD-IQR-INLFDSFEASRRACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVD 168

  Fly   122 NRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGI 186
            |::    ...:|:.|....:|.|..||:  :.:.||:.|:.||.::.|||||.::.....:...|
Zfish   169 NKD----SFYINLYPDYASISRAVLDIV--QFYKWKAVTVVYEDATGLIRLQELIKAPSRYSIKI 227

  Fly   187 KMQEFERGD-DYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLS 250
            |:::...|. |.|.|.|.:...:|..|:.||......||:...:...|...:.|.|.|.||.:..
Zfish   228 KIRQLPTGSKDARPLLKEMKKGKEFCVIFDCSYQTAADVLKQLLSMGMMTEYYHFFFTTLDLYSL 292

  Fly   251 GIDGF-YSRDFTVAVAAVRI------------------RTYVPPPVHDEIDVFDNSVDTRFSSLG 296
            .::.| ||   .|.:...|:                  |...||  ..|..:.|..:.|.
Zfish   293 DLEPFRYS---GVNMTGFRLLNIDNPQVASVVEKWSMERLQAPP--KPETGLQDGMMTTE----- 347

  Fly   297 SQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQ-----ITPKMVKPPFK 355
            :.|:||::.:...|....||   ..:.:..|.|.. |:.|.|.:...|:     :|.:::
Zfish   348 AALMYDAVYMVAAASQRASQ---ITVSSLQCHRHKPWRFGSRFISMFKEAQWNGLTGQII----- 404

  Fly   356 TQRLQIN-ADGQREDFNLEV----------------YNPIIDRVTHIWNKEFQLVDFEKLRENST 403
                 || .||.|:||:|::                :|.:..:: .:||....|        |.|
Zfish   405 -----INKTDGLRKDFDLDIISLKEDGLEKPLESGRFNKVWKKI-GVWNSNTGL--------NLT 455

  Fly   404 QALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECK 468
            .:.|.|.....:..:.:.:  .|.|.:..||..:::..:.::  ||:|||||.:||:..|:....
Zfish   456 DSNKDKNTNVTDSMANRTL--IVTTILENPYVMYKKSDKPLY--GNDRFEGYCLDLLKELSNILG 516

  Fly   469 FDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISI 533
            |.:..:.|.|.|||:.: :..||:|::|:|||:.|.:.:..||||..|..|:||:.|||.|||||
Zfish   517 FSYEVKLVTDGKYGAQN-DKGEWNGMVRELIDHVADLAVAPLTITYVREKVIDFSKPFMTLGISI 580

  Fly   534 LSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVE-NVNREMERQN 597
            |.:|.......:::||||.:.::|::|::|.:..:..|....|...|||..|.. |.:.::...|
Zfish   581 LYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENN 645

  Fly   598 IWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIG 662
             :.|.|::|..:|:::.||.:|:|:.|..|::...||.|.|:|..:|.|.||||:|..::...|.
Zfish   646 -FTLINSVWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMDSPID 709

  Fly   663 SLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGT 727
            |..||..|.|:::|.:|.|:|..:|.:|..:.....|..|.|.|..|..|||.||:.||..:  .
Zfish   710 SADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRKNTALVKNNREGIQRVLTT--D 772

  Fly   728 YAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNK 792
            ||.|||:|:::|..||||.|||||.....|.||:..|:.:.:|..:::.||:|.|.|:|..::.|
Zfish   773 YALLMESTSIEYISQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEK 837

  Fly   793 WFNSNESTCDSNVPTIDDGQ---FDMDSVGGLFVVLIVGVVVGLVIGVAEFLW------HVQRIS 848
            |:..|      ..|..|..:   ..::::||:|:||..|:|:.:.:.:.||::      .::.:|
Zfish   838 WWRGN------GCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNLDIEEVS 896

  Fly   849 V 849
            |
Zfish   897 V 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	106/419 (25%)
		ANF_receptor	41..378	CDD:279440	99/385 (26%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	136/373 (36%)
		Lig_chan	555..822	CDD:278489	91/270 (34%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	109/435 (25%)
		ANF_receptor	80..423	CDD:279440	98/373 (26%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	136/376 (36%)
		Lig_chan	602..871	CDD:278489	94/277 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591022
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850