DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GRIK5

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	887	Identity:	254/887 - (28%)
Similarity:	438/887 - (49%)	Gaps:	82/887 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QFLVLLALAIASGANEDTLVIKIGAIFFDTEM-----KLADAFSAALEEVNAINPALKLDAIKRY 64
            :.|:||.:|.||.:.:....:::.||..|..:     :|  |.:.|.|::|.|   :::.| |..
Human     4 ELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERL--ALALAREQINGI---IEVPA-KAR 62

  Fly    65 VTVD------DS-IVLQDISCDLIGSGVAAIFGPSSK-TNSDIVEVLCNMTGIPHLQFDWHPQQS 121
            |.||      || ....|..|.::..||.::.||||. .::..|..:|....|||::..  |:::
Human    63 VEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG--PEET 125

  Fly   122 NRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGI 186
            .|.:.....:|::.|....:|.|.|.||  |:|::.|.::...::..|:||:.::....:.|..:
Human   126 PRLQYLRFASVSLYPSNEDVSLAVSRIL--KSFNYPSASLICAKAECLLRLEELVRGFLISKETL 188

  Fly   187 KMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSG 251
            .::..:...|...|.|.|.:.:...:::|..:.|...::..:....||.:|....||.:|..:..
Human   189 SVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILH 253

  Fly   252 IDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRF-----------SSLGSQLVYDSIV 305
            :||.......:...::...::   |.:.|   |..|::..:           .:|.:.|::|::.
Human   254 LDGIVEDSSNILGFSMFNTSH---PFYPE---FVRSLNMSWRENCEASTYLGPALSAALMFDAVH 312

  Fly   306 LFYNALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQRED 369
            :..:|:.|:::.....:...:| ....|..|..|:..:     :||:....|.|::.|:.|||.:
Human   313 VVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYL-----RMVEYDGLTGRVEFNSKGQRTN 372

  Fly   370 FNLEVYNPIIDRVTH----IWNKEFQL-VDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATR 429
            :.|.:...  .|..|    :|.....| ::...|..|.:|.|..|.|             .|.|.
Human   373 YTLRILEK--SRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTL-------------VVTTI 422

  Fly   430 VGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGI 494
            :..||...|  |......|||||||:.||::..||:..:|.:....|.|..||:.:.| ..|.|:
Human   423 LENPYVMRR--PNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPN-GSWTGM 484

  Fly   495 IRQLID-NNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL 558
            :.:||: ..|.:.:...|||..|..|:||:.|||.||||||.......|...::||:|::..|||
Human   485 VGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWL 549

  Fly   559 FVMIAMMITAFALIFTGRIDQYEWDQPVENVN-REMERQNIWHLSNALWLVLGSMLNQGCDLLPR 622
            |:::|.:..:..|....|:..|||..|...:. |....:|.:.|.|:||..:|..:.||.:::||
Human   550 FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPR 614

  Fly   623 GLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYF 687
            .|..|.::..||.|.|:|..:|.|.||||:|..::...:.|..||.||..:::|||..|:|..:|
Human   615 ALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFF 679

  Fly   688 SESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGE 752
            ..|.....:..||.|.|.:|..|.|:.|||:.||..|:  ||||:|:|..:|:.:.||.|||||.
Human   680 QNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGG 742

  Fly   753 SFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ---FD 814
            ....|.|||.:||.:.||..:::.||:|.|...|..|:.||:....  |    |..:|.:   ..
Human   743 LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGR--C----PKEEDHRAKGLG 801

  Fly   815 MDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPM 856
            |:::||:|:|||.|:::.:.:.|.||:|..:|.:..|:.|.:
Human   802 MENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPAL 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	85/396 (21%)
		ANF_receptor	41..378	CDD:279440	77/356 (22%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	139/374 (37%)
		Lig_chan	555..822	CDD:278489	97/270 (36%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	85/396 (21%)
		ANF_receptor	42..379	CDD:279440	78/357 (22%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	141/388 (36%)
		Lig_chan	546..816	CDD:278489	101/277 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850