Protein Alignment GluRIIB and GRIK5

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 887
• Identity: 254/887 - (28%)
• Similarity: 438/887 - (49%)
• Gaps: 82/887 - (9%)

  Fly     5 QFLVLLALAIASGANEDTLVIKIGAIFFDTEM-----KLADAFSAALEEVNAINPALKLDAIKRY 64
            :.|:||.:|.||.:.:....:::.||..|..:     :|  |.:.|.|::|.|   :::.| |..
Human     4 ELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERL--ALALAREQINGI---IEVPA-KAR 62

  Fly    65 VTVD------DS-IVLQDISCDLIGSGVAAIFGPSSK-TNSDIVEVLCNMTGIPHLQFDWHPQQS 121
            |.||      || ....|..|.::..||.::.||||. .::..|..:|....|||::..  |:::
Human    63 VEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG--PEET 125

  Fly   122 NRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGI 186
            .|.:.....:|::.|....:|.|.|.||  |:|::.|.::...::..|:||:.::....:.|..:
Human   126 PRLQYLRFASVSLYPSNEDVSLAVSRIL--KSFNYPSASLICAKAECLLRLEELVRGFLISKETL 188

  Fly   187 KMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSG 251
            .::..:...|...|.|.|.:.:...:::|..:.|...::..:....||.:|....||.:|..:..
Human   189 SVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILH 253

  Fly   252 IDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRF-----------SSLGSQLVYDSIV 305
            :||.......:...::...::   |.:.|   |..|::..:           .:|.:.|::|::.
Human   254 LDGIVEDSSNILGFSMFNTSH---PFYPE---FVRSLNMSWRENCEASTYLGPALSAALMFDAVH 312

  Fly   306 LFYNALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQRED 369
            :..:|:.|:::.....:...:| ....|..|..|:..:     :||:....|.|::.|:.|||.:
Human   313 VVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYL-----RMVEYDGLTGRVEFNSKGQRTN 372

  Fly   370 FNLEVYNPIIDRVTH----IWNKEFQL-VDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATR 429
            :.|.:...  .|..|    :|.....| ::...|..|.:|.|..|.|             .|.|.
Human   373 YTLRILEK--SRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTL-------------VVTTI 422

  Fly   430 VGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGI 494
            :..||...|  |......|||||||:.||::..||:..:|.:....|.|..||:.:.| ..|.|:
Human   423 LENPYVMRR--PNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPN-GSWTGM 484

  Fly   495 IRQLID-NNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL 558
            :.:||: ..|.:.:...|||..|..|:||:.|||.||||||.......|...::||:|::..|||
Human   485 VGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWL 549

  Fly   559 FVMIAMMITAFALIFTGRIDQYEWDQPVENVN-REMERQNIWHLSNALWLVLGSMLNQGCDLLPR 622
            |:::|.:..:..|....|:..|||..|...:. |....:|.:.|.|:||..:|..:.||.:::||
Human   550 FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPR 614

  Fly   623 GLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYF 687
            .|..|.::..||.|.|:|..:|.|.||||:|..::...:.|..||.||..:::|||..|:|..:|
Human   615 ALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFF 679

  Fly   688 SESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGE 752
            ..|.....:..||.|.|.:|..|.|:.|||:.||..|:  ||||:|:|..:|:.:.||.|||||.
Human   680 QNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGG 742

  Fly   753 SFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ---FD 814
            ....|.|||.:||.:.||..:::.||:|.|...|..|:.||:....  |    |..:|.:   ..
Human   743 LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGR--C----PKEEDHRAKGLG 801

  Fly   815 MDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPM 856
            |:::||:|:|||.|:::.:.:.|.||:|..:|.:..|:.|.:
Human   802 MENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPAL 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	83/389 (21%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	139/374 (37%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	85/400 (21%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	141/388 (36%)