Protein Alignment CG7742 and TBC1D19

DIOPT Version :10

• Sequence 1: NP_608913.1
• Gene: CG7742 / 33750
• FlyBaseID: FBgn0031690
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: XP_047271859.1
• Gene: TBC1D19 / 55296
• HGNCID: 25624
• Length: 551
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 209/544 - (38%)
• Similarity: 313/544 - (57%)
• Gaps: 72/544 - (13%)

  Fly     1 MEELQDASIHHMTAKVIAAIKNTKSYEPIYKELQKLVCNPSVDTHDMRNTLEDAIKSAGLETEIR 65
            ::|..|.|:  :.|:::..:|.:..|..:.::....:..|.:....::..:::..|.:|.|.:::
Human     2 LQEESDLSL--IIAQIVQKLKGSNLYSQLERQAWASLQRPEIKLESLKEDIKEFFKISGWEKKLQ 64

  Fly    66 NIVYNLVRTRLSKTDDKNLANKQGAKPT-VSDPLGYLKRAGVLWDRRVRKSLNAMCTELKVPLHG 129
            |.||       |:.....|.:...|.|. :.:||.|:::|...|::|:.||||:|||||.:|| .
Human    65 NAVY-------SELSVFPLPSHPAAPPEHLKEPLVYMRKAQGSWEKRILKSLNSMCTELSIPL-A 121

  Fly   130 QPRISADREDFMAKWNELSNYNMDLANYRPVYAPKDLLEVLLSLKGPAKTTENTD---------- 184
            :.|...::::.:.||||:.....||:.:||||||||.||||::|:.|  ..||.|
Human   122 RKRPVGEQKELLNKWNEMGTDEPDLSLFRPVYAPKDFLEVLINLRNP--NYENGDSLSFRTHLGL 184

  Fly   185 -QIPQWEFSHIALPVKNLFELRAHYADLLRSDSYLGVPDLT-----------VQC-QRILEARHA 236
             |:|        |.||::.||:..:.:|..:...||:.|.|           |:. |::|..:.:
Human   185 IQVP--------LKVKDIPELKECFVELGLNIGQLGIDDSTQVPPELFENEHVRIGQKVLAEQDS 241

  Fly   237 PMCQQFLKKGCTPAPYRGALWASVLDSKLHDYDIEYWQKLRNAVWTTDHIVDKLVFKDIQLTASN 301
            ...||::::| :|...|..|||.:|:......|:.|:::|:..|...|.:||.|::||::|||||
Human   242 AAAQQYIRQG-SPTALRAELWALILNISSQPEDVLYYEQLKTNVIQHDLLVDSLIYKDVKLTASN 305

  Fly   302 DDQYFVFEDVLYQVLLCFSRDTDI-----------------G--GCVEYETFPVKGKTYEGPPSG 347
            ||.||||||.||||||||||||.:                 |  |..||..|      |  ||:|
Human   306 DDYYFVFEDYLYQVLLCFSRDTSVLSHFAFNSASPPKSYIRGKLGLEEYAVF------Y--PPNG 362

  Fly   348 VVPFHGICMFAAPFCYLYDSPVSLYYTFRAFYIRYCHRLTTINTHPQGIVSLCLLFEKLLQTYEP 412
            |:||||..|:.||.|:||..|..||..||..|:|:..||.:|::||.||||||||||.|||||.|
Human   363 VIPFHGFSMYVAPLCFLYHEPSKLYQIFREMYVRFFFRLHSISSHPSGIVSLCLLFETLLQTYLP 427

  Fly   413 QLWSHFRELQIQPLRVVFKWLMRAFSGHLPPDQLLVLWDLILGFDSLEILPLFAIIILSFRKESI 477
            ||:.|.||:..||||:.|||::|||||:|..||||:|||.|||::|||||.:.|..:.:||..::
Human   428 QLFYHLREIGAQPLRISFKWMVRAFSGYLATDQLLLLWDRILGYNSLEILAVLAAAVFAFRAVNL 492

  Fly   478 MQVASLDSIEAILADLSSIKVLPL 501
            |:|.||.:.|.:.|........||
Human   493 MEVTSLAAAENLAAHSEQFCTAPL 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7742	NP_608913.1	TBC	249..478	CDD:214540	125/247 (51%)
TBC1D19	XP_047271859.1	TBC	248..466	CDD:214540	113/226 (50%)