Protein Alignment Col4a1 and Col4a5

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001413925.1
• Gene: Col4a5 / 363457
• RGDID: 1565499
• Length: 1691
• Species: Rattus norvegicus
• Alignment Length: 1789
• Identity: 819/1789 - (45%)
• Similarity: 972/1789 - (54%)
• Gaps: 212/1789 - (11%)

  Fly    73 CTAGYAGCVPKC-----IAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRGD 132
            |::|     .||     ..|||.||.||..|..||.   ||||.|||.|.:|||||.|..|..|.
  Rat    32 CSSG-----SKCDCSGIKGEKGERGFPGLEGHPGLP---GFPGPEGPPGPRGQKGDDGIPGPPGP 88

  Fly   133 KGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSKG 197
            ||.||.|||.|..|.||:.|..|:.||||..|..||:|..|..|..|..|.||.:|..|..|..|
  Rat    89 KGIRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPG 153

  Fly   198 EKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGAS 262
            .||||.........|.||..|:.|..|:.||   ||.||..|.|||
  Rat   154 MKGEPGSIIMSSLPGPKGNQGYPGPPGIQGP---PGPKGVSGPSGP------------------- 196

  Fly   263 CYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDM-----GQKGEPGLVGRKGEPGPEGDTG 322
                  ||.||:.|..|.|...          ||:|:|     |.|||.|..|.:|.|||.|...
  Rat   197 ------PGPPGLMGPPGPPGPP----------GPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQIS 245

  Fly   323 -------LDGQKGEKGLPGGPGDRGRQGNFGPPGST-GQKGDRGEPGLNGLPGNPGQKGEPGRAG 379
                   ||.|||::|:||..|..|..|..||||.. |.||::||      ||.||::|:||:.|
  Rat   246 EQKRPIDLDFQKGDQGVPGDRGPPGPPGIPGPPGPPGGVKGEKGE------PGEPGKRGKPGKDG 304

  Fly   380 ATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGR 444
            .||:||:.|.||.| |..|.||..|.||.:|..|.|||.|.  |...||.....|.||..|.||.
  Rat   305 ETGQPGIPGLPGDP-GYPGEPGRHGEKGQKGDTGPPGPPGF--VIPTPGTGVTIGAKGNIGQPGL 366

  Fly   445 PGNEGPPGKKGEKGTAGLNGPKGS--IGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYP 507
            ||.:|..|..|.:|..|..||.|:  :||.|.||.||..|||||.|.||         ..|||.|
  Rat   367 PGEKGERGFPGIQGPPGFPGPPGTAVMGPPGPPGYPGERGQKGDEGPPG---------ICIPGSP 422

  Fly   508 GLKGSKGERGFKGNAGAPGDS--------KLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKG 564
            ||.|..|..||.|..|.||..        |.|.||.||:            ||..|.:|:.|:||
  Rat   423 GLDGQPGAPGFPGPPGPPGPQLPPSDEICKAGPPGPPGS------------PGDQGLQGEQGVKG 475

  Fly   565 DVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGP---PGEKGED 626
            |.|..|.:|..     .|.||.||.||..|..||||..|.|||:|..|..|.|||   ||..|..
  Rat   476 DKGDTCFNCIG-----TGISGPPGQPGLPGLPGPPGSLGIPGEKGEKGQAGTTGPKGLPGIPGPP 535

  Fly   627 GRTGLPGATGEPGKPALCDLSLIEPLKGDK---GYPGAPGAKGVQGFKGAEGLPGIPGPKGEFG- 687
            |..|.||:.|:||     |:..:..:||:|   |.|||||..|:.|..|.:||||:||||||.|
  Rat   536 GAPGFPGSKGDPG-----DVLTLPGMKGEKGELGSPGAPGLPGLPGSPGKDGLPGLPGPKGEPGG 595

  Fly   688 --FKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGS 750
              ||||:   |.|||.|.||..|..|..|..|....|..|..|..|..|:.|..|..|.||:||
  Rat   596 ITFKGER---GPPGNPGLPGLPGNMGPTGPVGFGPPGPVGEKGIQGVAGNPGQPGLPGPKGDPG- 656

  Fly   751 CALDEIKMPAK-GNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGE 814
               ..|..|.| |..|.||:.|..|.||:.|.||:.|..|:.|:.|..|.||: ||.|..||:|.
  Rat   657 ---QTISQPGKPGLPGNPGRDGEVGLPGDPGLPGQPGLPGIPGSKGEPGIPGI-GPPGPPGPKGF 717

  Fly   815 KGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQ---GEKGDRGPTGP 876
            .|..|..|.||.||:.|..|.||..|.|||:||||...|||.||||..|.:   |.|||||..||
  Rat   718 PGIPGPPGPPGAPGRMGPEGPPGLPGFPGPKGEPGFGLPGPPGPPGFPGFKGTPGPKGDRGLPGP 782

  Fly   877 IGFPGADGSVGYPGDRGDA---GLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDG 938
            .|.||..|..|.||.:|||   |.||..|.||:.| .|..||.||.|..||.|.||:.|:   .|
  Rat   783 PGPPGHTGLDGLPGPKGDAGPNGQPGPIGPPGLPG-IGLQGPPGPPGTPGPIGQPGLHGI---PG 843

  Fly   939 AKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGND 1003
            .||:||.||| .:||..|:||:||..|..|..|..|:||..|.||:||..|.||:.|..|..|..
  Rat   844 EKGDPGPPGL-DVPGLPGERGSPGLPGAPGLIGPPGSPGIPGRAGVPGFPGVKGEMGMMGPPGPP 907

  Fly  1004 GPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPG--LPGDASEKGQK 1066
            ||:|..|..|||||   |||.|:.|.|   ||.|..||||.:|.|||.||||  .|.....||:|
  Rat   908 GPLGTPGRSGAPGL---KGDDGMQGQP---GLPGPVGEKGGKGEPGLPGPPGPMRPDFLGSKGEK 966

  Fly  1067 GEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQ 1131
            |:||..|:.|.:||.|..|.||:.|.|||:  |:.|.||..|.:|..|:.|..|:.
  Rat   967 GDPGLPGIPGLSGPKGYQGLPGDPGQPGLS--GQPGSPGLPGPKGTPGLPGPPGLT--------- 1020

  Fly  1132 GVWGQPGEKGSVGAPGIPGAPGMD---GLPGAAGAPGAVGYPGDRGDKGEPGLS--GLPGLKGET 1191
               |.||.||::|..|.||..|:|   |.||..|.||:.|.||.:|.|||||:|  |||||.|..
  Rat  1021 ---GPPGPKGNIGDMGFPGPQGVDGPPGPPGGPGQPGSPGLPGQKGSKGEPGVSGIGLPGLPGPK 1082

  Fly  1192 GPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAG 1256
            |..||.|:.|.||.||..|..|.||||.:    .|.||..|..|:.|..|..|.:|:.||.|..|
  Rat  1083 GEPGLPGYPGNPGIKGSMGEAGLPGLPGS----PGAKGQPGLPGFPGTPGLPGPKGMNGPPGNPG 1143

  Fly  1257 AKGD------RGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIG 1315
            ..|:      .|..||||..|..|.||..|..||.|:.|.||....|..|.||.||.:|::|..|
  Rat  1144 LPGEPGPVGGGGRPGPPGPPGEKGKPGQDGIPGPAGQKGEPGQPGFGIPGPPGLPGLSGQKGDGG 1208

  Fly  1316 APGLIGERGLPGLAGEP---GLVGLPGPIGPAGS--------KGERGLAGSPGQPGQDGFPGAPG 1369
            ||||.|..||||..|||   |..|:|||.||.||        ||..|..|.||:||..||.|.||
  Rat  1209 APGLPGNPGLPGSKGEPGFQGFPGMPGPPGPPGSPGPSLEGPKGNPGPQGPPGRPGPPGFQGPPG 1273

  Fly  1370 LKGDTGPQ---GFKGERGLNGFEGQ------KGDKGDRGLQGPSGLPGLVGQKGDTGYPGL---N 1422
            .:|..||.   |.|||||..|..||      |||:|..||.|..|.|||.|.|||.|.||:   .
  Rat  1274 TEGPRGPPGNGGIKGERGNPGPPGQPGLPGLKGDQGPPGLPGNPGRPGLNGMKGDPGLPGVPGFP 1338

  Fly  1423 GNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLP-PPGPKGEPGQPGRNGPKGEPGRPG 1486
            |..||:|.||..|..|..|..|..|.|||||..|:..::. .|||.|.|||||.   ||.||.||
  Rat  1339 GMKGPIGVPGSTGPDGEPGLTGPPGPPGLPGPSGQSIVIKGDPGPPGIPGQPGL---KGLPGLPG 1400

  Fly  1487 ERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGEPGAPAPAALD 1551
            .:||.|..|..|:.|..||.|..|..||.|..|..|:||.||.:|..|..|.:|.||.|...::.
  Rat  1401 PQGLPGPIGPPGDPGRNGLPGFDGAGGRKGDPGLPGQPGSRGLDGPPGPDGLQGPPGPPGTTSVA 1465

  Fly  1552 YLTGILITRHSQSETVPACSAGHTELWTGYSLLYVDGNDYAHNQDLGSPGSCVPRFSTLPVLSCG 1616
            :  |.|||||||:...|.|..|...::.|:|||||.||..||.||||:.|||:.||||:|.:.|.
  Rat  1466 H--GFLITRHSQTTDAPQCPQGTVHIYDGFSLLYVQGNKRAHGQDLGTAGSCLRRFSTMPFMFCN 1528

  Fly  1617 QNNVCNYASRNDKTFWLTTNAAIP--MMPVENIEIRQYISRCVVCEAPANVIAVHSQTIEVPDCP 1679
            .|||||:|||||.::||:|...:|  |.|::...|:.:||||.||||||.|||||||||::|.||
  Rat  1529 INNVCNFASRNDYSYWLSTPEPMPMNMEPLKGQSIQPFISRCAVCEAPAVVIAVHSQTIQIPHCP 1593

  Fly  1680 NGWEGLWIGYSFLMHTAVGNGGGGQALQSPGSCLEDFRATPFIECNGAKGTCHFYETMTSFWMYN 1744
            .||:.|||||||:|||:.|..|.||||.|||||||:||:.|||||:| :|||::|....|||:..
  Rat  1594 QGWDSLWIGYSFMMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHG-RGTCNYYANSYSFWLAT 1657

  Fly  1745 LESSQPFERPQQQTIKAGERQSHVSRCQVCMKNS 1778
            ::.|..|.:||.:|:|||:.::.:||||||||.:
  Rat  1658 VDMSDMFSKPQSETLKAGDLRTRISRCQVCMKRT 1691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478	109/266 (41%)
		gly_rich_SclB	<355..>642	CDD:468478	129/299 (43%)
		gly_rich_SclB	<543..820	CDD:468478	122/286 (43%)
		gly_rich_SclB	<727..>968	CDD:468478	117/247 (47%)
		gly_rich_SclB	<969..>1218	CDD:468478	119/255 (47%)
		gly_rich_SclB	<1186..>1420	CDD:468478	119/259 (46%)
		gly_rich_SclB	<1321..>1547	CDD:468478	118/249 (47%)
		C4	1555..1662	CDD:128421	58/108 (54%)
		C4	1663..1777	CDD:128421	68/113 (60%)
Col4a5	NP_001413925.1	None