Protein Alignment Col4a1 and COL28A1

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001032852.2
• Gene: COL28A1 / 340267
• HGNCID: 22442
• Length: 1125
• Species: Homo sapiens
• Alignment Length: 783
• Identity: 295/783 - (37%)
• Similarity: 348/783 - (44%)
• Gaps: 253/783 - (32%)

  Fly   544 QKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGER 608
            :|||.|.||.||..|:.||||:         .||||:.|.:                ::|..|||
Human   243 EKGDPGDPGPPGTHGNPGIKGE---------RGPKGNPGNA----------------QKGEAGER 282

  Fly   609 GHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGA 673
            |..||.|..|..||:||.|:.|                     :|||||.||..|.||.:|.:|.
Human   283 GPGGIPGYKGDKGERGECGKPG---------------------IKGDKGSPGPYGPKGPRGIQGI 326

  Fly   674 EGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGS 738
            .|.||.||||   ||:|.||..|.||..|:||.      |||..|.||||.|..||.||.|..|
Human   327 TGPPGDPGPK---GFQGNKGEPGPPGPYGSPGA------PGIGQQGIKGERGQEGRPGAPGPIG- 381

  Fly   739 FGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVE 803
                                     .|||||   |||.|.:|.|||||..|
Human   382 -------------------------VGEPGQ---PGPRGPEGVPGERGLPG-------------- 404

  Fly   804 GPRGLNGPRGEKGNQGAVGVPGNPGKDGLRG--IPGRNGQPGPRGEPGISRPGPMGPPGLNGLQG 866
              .|..||:||||::|..      |..||:|  |.|..|..||.|.     .||||.||: |.||
Human   405 --EGFPGPKGEKGSEGPT------GPQGLQGLSIKGEKGDIGPVGP-----QGPMGIPGI-GSQG 455

  Fly   867 EKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGID 931
            |:|.:||.||            ||.:|.||       .|:.|.||:||.:||.|..||.|:
Human   456 EQGIQGPIGP------------PGPQGPAG-------QGLPGSKGEVGQMGPTGPRGPVGI---- 497

  Fly   932 GVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGA 996
               |..|.||||||.||.|.|      |.||.||..|..|..|.||.|||.|.|
Human   498 ---GVQGPKGEPGSIGLPGQP------GVPGEDGAAGKKGEAGLPGARGPEGPP----------- 542

  Fly   997 TGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDAS 1061
                       |:|.||.      |||:|..|:.|.||..|:||.:|.:|.||:.||.|:||.:.
Human   543 -----------GKGQPGP------KGDEGKKGSKGNQGQRGLPGPEGPKGEPGIMGPFGMPGTSI 590

  Fly  1062 EKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKG 1126
                   |||.|.:||.|..|.||:.||.||                           .|.|.||
Human   591 -------PGPPGPKGDRGGPGIPGFKGEPGL---------------------------SIRGPKG 621

  Fly  1127 EQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGET 1191
            .||.:|..|.||.||. |.||:||..|:.|.||..|..|.    ||.|.|||||:.|.|   |.:
Human   622 VQGPRGPVGAPGLKGD-GYPGVPGPRGLPGPPGPMGLRGV----GDTGAKGEPGVRGPP---GPS 678

  Fly  1192 GPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGY--TGEKGEQGERGLTGPAGV 1254
            ||.|:    |..||||:.|.:|.||.|             |..||  .|.|||||.:|..||.|.
Human   679 GPRGV----GTQGPKGDTGQKGLPGPP-------------GPPGYGSQGIKGEQGPQGFPGPKGT 726

  Fly  1255 AGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGL 1319
            .|                :|:||.||:.|.||::|..|  .|||.|.||.||:.|.||..|..||
Human   727 MG----------------HGLPGQKGEHGERGDVGKKG--DKGEIGEPGSPGKQGLQGPKGDLGL 773

  Fly  1320 IGE 1322
            ..|
Human   774 TKE 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478
		gly_rich_SclB	<355..>642	CDD:468478	33/97 (34%)
		gly_rich_SclB	<543..820	CDD:468478	101/275 (37%)
		gly_rich_SclB	<727..>968	CDD:468478	89/242 (37%)
		gly_rich_SclB	<969..>1218	CDD:468478	93/248 (38%)
		gly_rich_SclB	<1186..>1420	CDD:468478	53/139 (38%)
		gly_rich_SclB	<1321..>1547	CDD:468478	1/2 (50%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
COL28A1	NP_001032852.2	vWFA_subfamily_ECM	47..209	CDD:238727
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..769		291/774 (38%)
		gly_rich_SclB	<272..>582	CDD:468478	173/472 (37%)
		gly_rich_SclB	<478..>759	CDD:468478	153/398 (38%)
		VWA	798..974	CDD:459670
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	999..1066
		Kunitz-type	1072..1122	CDD:444694