Protein Alignment Col4a1 and COL17A1

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_000485.3
• Gene: COL17A1 / 1308
• HGNCID: 2194
• Length: 1497
• Species: Homo sapiens
• Alignment Length: 1184
• Identity: 367/1184 - (30%)
• Similarity: 444/1184 - (37%)
• Gaps: 414/1184 - (34%)

  Fly    87 EKGN-RGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGV 150
            |.|| ||.|||                     ||..|.|||      ||:||.|      |.||:
Human   561 ENGNLRGSPGP---------------------KGDMGSPGP------KGDRGFP------GTPGI 592

  Fly   151 QGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKG 215
            .||.|:||..|..|:.|..|.   ||:||..|.   ||..|.:|.:||.|.|       ..||||
Human   593 PGPLGHPGPQGPKGQKGSVGD---PGMEGPMGQ---RGREGPMGPRGEAGPP-------GSGEKG 644

  Fly   216 EPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGE 280
            |.|..|..|..||.|.||..|.:|.||..|.:||.|..||:|.:|       :.|.||:||:||
Human   645 ERGAAGEPGPHGPPGVPGSVGPKGSSGSPGPQGPPGPVGLQGLRG-------EVGLPGVKGDKG- 701

  Fly   281 PASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNF 345
                 |:.|.    ||:||.|:||..||.   |||            |.:||||..|:.|.:|..
Human   702 -----PMGPP----GPKGDQGEKGPRGLT---GEP------------GMRGLPGAVGEPGAKGAM 742

  Fly   346 GPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRG 410
            ||.|..|.:|.|||.||.|:   ||.:|.||.:|..|||||.||.||    :|.||.||..|.:|
Human   743 GPAGPDGHQGPRGEQGLTGM---PGIRGPPGPSGDPGKPGLTGPQGP----QGLPGTPGRPGIKG 800

  Fly   411 YVGAPG----PQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGTAGLNGPKGSIGP 471
            ..||||    .:| :.:..:|||.|..|..|..|.||.||..||.|..|.:....|.||.|..||
Human   801 EPGAPGKIVTSEG-SSMLTVPGPPGPPGAMGPPGPPGAPGPAGPAGLPGHQEVLNLQGPPGPPGP 864

  Fly   472 IGHPGP--PGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPG 534
            .|.|||  |||.|.:|..|            .|:||.||..||     |..|      |:....|
Human   865 RGPPGPSIPGPPGPRGPPG------------EGLPGPPGPPGS-----FLSN------SETFLSG 906

  Fly   535 TPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGA---- 595
            .||..|.||.|||.|.|                        ||:|.:|..||||......:
Human   907 PPGPPGPPGPKGDQGPP------------------------GPRGHQGEQGLPGFSTSGSSSFGL 947

  Fly   596 --RGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGY 658
              :|||               |..||.|.||:.|..|:|||.|.|..|:             :|
Human   948 NLQGPP---------------GPPGPQGPKGDKGDPGVPGALGIPSGPS-------------EG- 983

  Fly   659 PGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEK-------------------GLSGAPGNDGTP 704
                |:.......|..|.||.|||.|.....|::                   |:.|.||..|.|
Human   984 ----GSSSTMYVSGPPGPPGPPGPPGSISSSGQEIQQYISEYMQSDSIRSYLSGVQGPPGPPGPP 1044

  Fly   705 GRAGRDGYPGIPGQSIKGEPGFHG----------------------------------RDGAK-- 733
            |          |..:|.||...:.                                  ||..:
Human  1045 G----------PVTTITGETFDYSELASHVVSYLRTSGYGVSLFSSSISSEDILAVLQRDDVRQY 1099

  Fly   734 ------GDKGSFGRSGEKGEPGSCALDEIKMPAK--GNKGEPG-QTGMPGPPGEDGSPGE----- 784
                  |.:|..|..|..|:....:||..::.::  ......| ..|:|||||..|.||.
Human  1100 LRQYLMGPRGPPGPPGASGDGSLLSLDYAELSSRILSYMSSSGISIGLPGPPGPPGLPGTSYEEL 1164

  Fly   785 ----RG--YTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKD------------- 830
                ||  :.|:.|..||.|||                     |:|||....
Human  1165 LSLLRGSEFRGIVGPPGPPGPP---------------------GIPGNVWSSISVEDLSSYLHTA 1208

  Fly   831 GLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDA 895
            ||..|||..|.|||        |||.||||::|                    ....|..:..|
Human  1209 GLSFIPGPPGPPGP--------PGPRGPPGVSG--------------------ALATYAAENSD- 1244

  Fly   896 GLPGVSGRPGIVG-------EKGDVGPIGPAGVAGPPG---VPGIDGVRGRDGAKGEPGSPGLVG 950
                 |.|..::.       ....|||.||.|..||||   :...|....|..:.....|....|
Human  1245 -----SFRSELISYLTSPDVRSFIVGPPGPPGPQGPPGDSRLLSTDASHSRGSSSSSHSSSVRRG 1304

  Fly   951 MPGNKGDRGAPGNDGPKGFAGVTG-APGKRGPAGI---PGVSGAKGDKGATGLTGNDGPVGGRGP 1011
            ...:.......|..|..|..|..| |.|.|||.|.   ||        |..|.....|...|.|
Human  1305 SSYSSSMSTGGGGAGSLGAGGAFGEAAGDRGPYGTDIGPG--------GGYGAAAEGGMYAGNG- 1360

  Fly  1012 PGAPGLMG--IKGD--------------------QGLA----GAPGQQGLDGMPG------EKGN 1044
                ||:|  ..||                    ||:|    |.|||.|..|.||      ...|
Human  1361 ----GLLGADFAGDLDYNELAVRVSESMQRQGLLQGMAYTVQGPPGQPGPQGPPGISKVFSAYSN 1421

  Fly  1045 ---------QGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGR 1100
                     |.:..:.||||      :||:.|.|||   :||.||||.||.||..|     ..|.
Human  1422 VTADLMDFFQTYGAIQGPPG------QKGEMGTPGP---KGDRGPAGPPGHPGPPG-----PRGH 1472

  Fly  1101 AGPPGEKGDQGRSG 1114
            .|..|:||||..:|
Human  1473 KGEKGDKGDQVYAG 1486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478	98/253 (39%)
		gly_rich_SclB	<355..>642	CDD:468478	110/298 (37%)
		gly_rich_SclB	<543..820	CDD:468478	81/357 (23%)
		gly_rich_SclB	<727..>968	CDD:468478	69/319 (22%)
		gly_rich_SclB	<969..>1218	CDD:468478	62/191 (32%)
		gly_rich_SclB	<1186..>1420	CDD:468478
		gly_rich_SclB	<1321..>1547	CDD:468478
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
COL17A1	NP_000485.3	Nonhelical region (NC16)	1..566		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..154
		Necessary for interaction with DST and for the recruitment of DST to hemidesmosome. /evidence=ECO:0000269|PubMed:12482924	145..230
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..186
		gly_rich_SclB	508..>807	CDD:468478	134/330 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..1011		222/614 (36%)
		Triple-helical region	567..1482		360/1172 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1209..1234		17/52 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1261..1316		14/54 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1434..1497		29/67 (43%)
		Nonhelical region (NC1)	1483..1497		1/4 (25%)