Protein Alignment Col4a1 and COL13A1

DIOPT Version :10

• Sequence 1: NP_723044.1
• Gene: Col4a1 / 33727
• FlyBaseID: FBgn0000299
• Length: 1779
• Species: Drosophila melanogaster
• Sequence 2: NP_001355811.1
• Gene: COL13A1 / 1305
• HGNCID: 2190
• Length: 728
• Species: Homo sapiens
• Alignment Length: 955
• Identity: 328/955 - (34%)
• Similarity: 403/955 - (42%)
• Gaps: 298/955 - (31%)

  Fly   515 ERGFKGNA-GAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPG----------------------- 555
            ||..|..| ||.|..:||.|||.....|..::|  .|..:||
Human     4 ERTHKAAATGARGPGELGAPGTVALVAARAERG--ARLPSPGSCGLLTLALCSLALSLLAHFRTA 66

  Fly   556 -----------QKGDMGIKGDVGGKCSSC------------RAGPKGDKGTSGLPGIPGKDGARG 597
                       ::|:..::..:.|:.:..            |..||...|.:..||.||..|..|
Human    67 ELQARVLRLEAERGEQQMETAILGRVNQLLDEKWKLHSRRRREAPKTSPGCNCPPGPPGPTGRPG 131

  Fly   598 PPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLP--GATGEPGKPALCDLSLIEPLKGDKGYPG 660
            .||::|..|..|..|:.||   |||||..|..||.  |..|.||:|            |.:|:||
Human   132 LPGDKGAIGMPGRVGVKGQ---PGEKGSPGDAGLSIIGPRGPPGQP------------GTRGFPG 181

  Fly   661 APGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPG 725
            .||..|:      :|.||.|||||:.      ||:|.||.            ||..||
Human   182 FPGPIGL------DGKPGHPGPKGDM------GLTGPPGQ------------PGPQGQ------- 215

  Fly   726 FHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKM------PAKGNKGEPGQTGMPGPPGEDGSPGE 784
                   ||:||..|....:..|   .|:.:::      ..:..:||..|..:.|||
Human   216 -------KGEKGQCGEYPHRLLP---LLNSVRLAPPPVIKRRTFQGEQSQASIQGPP-------- 262

  Fly   785 RGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPG 849
                      ||.|||                                       |..||.|.||
Human   263 ----------GPPGPP---------------------------------------GPSGPLGHPG 278

  Fly   850 ISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVG 914
            :  |||||||||         .||.||.|.||..   ||.|.:|:.|:||:.|:.|..|..|
Human   279 L--PGPMGPPGL---------PGPPGPKGDPGIQ---GYHGRKGERGMPGMPGKHGAKGAPG--- 326

  Fly   915 PIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKR 979
             |..||:.|.||:|   |.:|..||:|:||.|||:|..|.:|::||.|:
Human   327 -IAVAGMKGEPGIP---GTKGDPGAEGKPGPPGLLGKRGQRGEKGAEGS---------------- 371

  Fly   980 GPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGN 1044
              .|:||:.|.||:||..|    :...||||.||.|                  ||.|.||.||.
Human   372 --PGLPGLLGQKGEKGDAG----NSIGGGRGEPGPP------------------GLPGPPGPKGE 412

  Fly  1045 QGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGD 1109
            .|..|..||||.|||..|:|..||.||.      ||.|:.|.||                  ||:
Human   413 AGVDGQVGPPGQPGDKGERGAAGEQGPD------GPKGSKGEPG------------------KGE 453

  Fly  1110 QGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRG 1174
            .    :|....||....|.....:.|.||..|.:|.||.||.||.   .|..|.||..|:.|::|
Human   454 M----VDYNGNINEALQEIRTLALMGPPGLPGQIGPPGAPGIPGQ---KGEIGLPGPPGHDGEKG 511

  Fly  1175 DKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGE 1239
            .:|:||..|.|      ||.|..|..|.||.|||.|..|.||       .:|:||..|:.|..||
Human   512 PRGKPGDMGPP------GPQGPPGKDGPPGVKGENGHPGSPG-------EKGEKGETGQAGSPGE 563

  Fly  1240 KGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGR 1304
            |||.||:|..| |.|.|..|.   :||||..||.|:|      ||:||.|..|.  |||||..|.
Human   564 KGEAGEKGNPG-AEVPGLPGP---EGPPGPPGLQGVP------GPKGEAGLDGA--KGEKGFQGE 616

  Fly  1305 PGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPG 1369
            .|..|..||.||.||.|.   ||..|.||.:|:|||.||   |||||..|.||..|..|..|.||
Human   617 KGDRGPLGLPGASGLDGR---PGPPGTPGPIGVPGPAGP---KGERGSKGDPGMTGPTGAAGLPG 675

  Fly  1370 LKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQG-----PSGLPGL 1409
            |.|..|.:|.:||||..|..|.||||||:|..|     |.|..||
Human   676 LHGPPGDKGNRGERGKKGSRGPKGDKGDQGAPGLDAPCPLGEDGL 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478
		gly_rich_SclB	<355..>642	CDD:468478	49/175 (28%)
		gly_rich_SclB	<543..820	CDD:468478	79/330 (24%)
		gly_rich_SclB	<727..>968	CDD:468478	74/246 (30%)
		gly_rich_SclB	<969..>1218	CDD:468478	87/248 (35%)
		gly_rich_SclB	<1186..>1420	CDD:468478	107/229 (47%)
		gly_rich_SclB	<1321..>1547	CDD:468478	47/94 (50%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
COL13A1	NP_001355811.1	gly_rich_SclB	<188..>451	CDD:468478	135/445 (30%)
		gly_rich_SclB	<340..>573	CDD:468478	116/316 (37%)
		gly_rich_SclB	<463..>712	CDD:468478	127/282 (45%)