DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col16a1

DIOPT Version :10

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001391281.1	Gene:	Col16a1 / 107581	MGIID:	1095396	Length:	1598	Species:	Mus musculus

Alignment Length:	1576	Identity:	594/1576 - (37%)
Similarity:	716/1576 - (45%)	Gaps:	416/1576 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GVARGDLPP-------KNCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMG-----------F 108
            |....:.||       .|.|.|.:|..    ..||.|||.||.||.|.||..|           .
Mouse   310 GTGVNECPPCAHSARESNVTLGPSGLK----GGKGERGLTGPSGPKGEKGARGNDCVRVSPDAPL 370

  Fly   109 PGMEGPSGDKGQKGD------PGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDG 167
            ..:|||.|:||:.||      |||.||:|.|||:|..||   .|:||..|..|.||...:.|..|
Mouse   371 QCVEGPKGEKGESGDLGPPGLPGPTGQKGQKGEKGDGGL---KGLPGKPGRDGRPGEICVIGPKG 432

  Fly   168 CDGQDGIPGLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFP 232
            ..|..|..|.|||:|.|||.|..|..|.    |.|         |..|:||        ||   |
Mouse   433 QKGDPGFVGPEGLAGEPGPPGLPGPPGI----GLP---------GTPGDPG--------GP---P 473

  Fly   233 GEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPR 297
            |.|||:|.||..|.:||.|:             |.|||.||.|||||:|....|..|
Mouse   474 GPKGEKGSSGIPGKEGPGGK-------------PGKPGVPGTKGEKGDPCEVCPTLP-------- 517

  Fly   298 GDMGQKGEPGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGL 362
                 :|....||..|:|||:|:.| |.....:||                |:.|.|||||:||:
Mouse   518 -----EGSQNFVGLPGKPGPKGEPG-DPAPAWEGL----------------GTVGLKGDRGDPGI 560

  Fly   363 NGLPGNPGQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLP 427
            .|:   .|:||||..:.::|.......|.|   |.|.||.||..      |.|||:||.
Mouse   561 QGM---KGEKGEPCSSCSSGVGAQHLGPSP---GHGLPGLPGTS------GIPGPRGLK------ 607

  Fly   428 GPQGYNGQKGGAGLPGRPGNEGPPGKKGEKG------TAGLNGPKGSIGPIGHPGPPGPEGQKGD 486
            |.:|..|..|.||:||.||..||.|.||.||      ||......|.:..: |  .|||.|:||:
Mouse   608 GEKGSFGDTGPAGVPGSPGPVGPAGIKGAKGEPCEPCTALSELQDGDMRVV-H--LPGPAGEKGE 669

  Fly   487 AGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRP 551
            .|.||:|:.|.:|.|         |.:|.:|.||:||.|||     |||||..|.||..|:
Mouse   670 PGSPGFGLPGKQGKA---------GERGLKGQKGDAGNPGD-----PGTPGITGQPGISGE---- 716

  Fly   552 GTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQ 616
              ||.:|..|.||:.|..|::|.:........|||||.||..|..||.|. |:||:.|..|:.|.
Mouse   717 --PGIRGPAGPKGEKGDGCTACPSLQGALTDVSGLPGKPGPKGEPGPEGV-GHPGKPGQPGLPGV 778

  Fly   617 TGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLP---G 678
            .||||.||..|..|.||.                            ||:|.||..|.:|||   |
Mouse   779 QGPPGPKGTQGEPGPPGT----------------------------GAEGPQGEPGTQGLPGTQG 815

  Fly   679 IPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSG 743
            :|||:|..|..||||..|:||..|..|..|.      ||..:.|.|         |.|||   .|
Mouse   816 LPGPRGPPGSAGEKGAQGSPGPKGAIGPMGP------PGAGVSGPP---------GQKGS---RG 862

  Fly   744 EKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGL 808
            ||||||.|:..        ::|||..:||||.||.        :.|.....||||||||.||
Mouse   863 EKGEPGECSCP--------SRGEPIFSGMPGAPGL--------WMGSSSQPGPQGPPGVPGP--- 908

  Fly   809 NGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEK----- 868
                           ||.||..||:|:||.||.|   |:||::..       |..|..||
Mouse   909 ---------------PGPPGMPGLQGVPGHNGLP---GQPGLTAE-------LGSLPIEKHLLKS 948

  Fly   869 --GDRGPTGPIGFPGADGSVGYP------GDRGDAGLPGVSG------------RPGIVGEKGDV 913
              ||          .|.|...:|      |::||.|:|||.|            ||.....:|
Mouse   949 ICGD----------CAQGQTAHPAFLLEKGEKGDQGIPGVPGFDNCARCFIERERPRAEEARG-- 1001

  Fly   914 GPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGK 978
                             |...|..|..|.||.||..||||.:|:.|.|         |:.|:||.
Mouse  1002 -----------------DNSEGEPGCSGSPGLPGPPGMPGQRGEEGPP---------GMRGSPGP 1040

  Fly   979 RGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKG 1043
            .||.|.||..||                     .|:|||.|::|::||.|..|.:   |.||..|
Mouse  1041 PGPIGPPGFPGA---------------------VGSPGLPGLQGERGLTGLTGDK---GEPGPPG 1081

  Fly  1044 NQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKG 1108
            ..|:||..|||||||   .||::|..||||.:|::||      ||.:||||  ..|.|||.||:|
Mouse  1082 QPGYPGAMGPPGLPG---IKGERGYTGPSGEKGESGP------PGSEGLPG--PQGPAGPRGERG 1135

  Fly  1109 DQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDR 1173
            .||.|         ||||:||.|            |.||.||.||..|.||.|||||..|...::
Mouse  1136 PQGSS---------GEKGDQGFQ------------GQPGFPGPPGPPGFPGKAGAPGPPGPQAEK 1179

  Fly  1174 GDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTG 1238
            |.:|..|.|||||..|..||.|:|      ||.|..|:.|:.|.|.    :|||.|..|..|..|
Mouse  1180 GSEGIRGPSGLPGSPGPPGPPGIQ------GPAGLDGLDGKDGKPG----LRGDPGPAGPPGLMG 1234

  Fly  1239 EKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPG 1303
            ..|.:|:   ||..|:.|.|||.|..||||:||..|..|..|.:||:|..|.||..  |.:|.||
Mouse  1235 PPGFKGK---TGHPGLPGPKGDCGKPGPPGSSGRPGAEGEPGAMGPQGRPGPPGHL--GPQGPPG 1294

  Fly  1304 RPGRNGRQ--GLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPG 1366
            :||..|..  ||.|..|:.|||||.||.|:||..|.|||.|..||.   |.||..|.||:.|..|
Mouse  1295 QPGPPGLSTVGLKGDRGVPGERGLAGLPGQPGTPGHPGPPGEPGSD---GAAGKEGPPGKQGLYG 1356

  Fly  1367 APGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAP 1431
            .||.|||.||.|.||:.|..|..|..|..|..|..||.|.||..|::|..|.||..||.|..|.|
Mouse  1357 PPGPKGDPGPAGQKGQAGEKGRSGMPGGPGKSGSMGPIGPPGPAGERGHPGSPGPAGNPGLPGLP 1421

  Fly  1432 GERG--------------------------FTG----PKGRDGRDGTPGLPGQKGEPGMLPPPGP 1466
            |..|                          :|.    |.......|.||.||:.|.||.   ||.
Mouse  1422 GSMGDMVNYDDIKRFIRQEIIKLFDERMAYYTSRMQFPMEVAAAPGRPGPPGKDGAPGR---PGA 1483

  Fly  1467 KGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEG 1531
            .|.||.||:.|.:|..|.||.|||.|.:||:|:.|    :|..|..|.|||.|.:|.|| .|..|
Mouse  1484 PGSPGLPGQIGREGRQGLPGMRGLPGTKGEKGDIG----VGIAGENGLPGPPGPQGPPG-YGKMG 1543

  Fly  1532 AIGLIGQKGEPGAPAP 1547
            |.|.:||:|.||.|.|
Mouse  1544 ATGPMGQQGIPGIPGP 1559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	gly_rich_SclB	<107..>361	CDD:468478	96/270 (36%)
		gly_rich_SclB	<355..>642	CDD:468478	116/292 (40%)
		gly_rich_SclB	<543..820	CDD:468478	99/279 (35%)
		gly_rich_SclB	<727..>968	CDD:468478	82/265 (31%)
		gly_rich_SclB	<969..>1218	CDD:468478	103/248 (42%)
		gly_rich_SclB	<1186..>1420	CDD:468478	105/235 (45%)
		gly_rich_SclB	<1321..>1547	CDD:468478	108/255 (42%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
Col16a1	NP_001391281.1	TSPN	50..231	CDD:214560
		Nonhelical region 10 (NC10). /evidence=ECO:0000255	232..374		20/67 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..547		105/296 (35%)
		gly_rich_SclB	<331..>541	CDD:468478	101/267 (38%)
		Triple-helical region 9 (COL9) with 3 imperfections. /evidence=ECO:0000255	375..509		72/173 (42%)
		gly_rich_SclB	<503..>725	CDD:468478	106/292 (36%)
		Nonhelical region 9 (NC9). /evidence=ECO:0000255	510..524		3/26 (12%)
		Triple-helical region 8 (COL8) with 1 imperfection. /evidence=ECO:0000255	525..570		23/64 (36%)
		Cell attachment site. /evidence=ECO:0000255	555..557		1/1 (100%)
		Nonhelical region 8 (NC8). /evidence=ECO:0000255	571..586		1/14 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..935		179/471 (38%)
		Triple-helical region 7 (COL7) with 1 imperfection. /evidence=ECO:0000255	587..640		30/67 (45%)
		Nonhelical region 7 (NC7). /evidence=ECO:0000255	641..661		4/22 (18%)
		Triple-helical region 6 (COL6) with 1 imperfection. /evidence=ECO:0000255	662..732		38/89 (43%)
		gly_rich_SclB	<665..>868	CDD:468478	103/269 (38%)
		Nonhelical region 6 (NC6). /evidence=ECO:0000255	733..747		2/13 (15%)
		Triple-helical region 5 (COL5) with 3 imperfections. /evidence=ECO:0000255	748..870		66/168 (39%)
		gly_rich_SclB	<827..>1144	CDD:468478	159/460 (35%)
		Nonhelical region 5 (NC5). /evidence=ECO:0000255	871..881		3/17 (18%)
		Triple-helical region 4 (COL4) with 2 imperfections. /evidence=ECO:0000255	882..933		32/79 (41%)
		Nonhelical region 4 (NC4). /evidence=ECO:0000255	934..967		9/49 (18%)
		Triple-helical region 3 (COL3). /evidence=ECO:0000255	968..982		8/13 (62%)
		Nonhelical region 3 (NC3). /evidence=ECO:0000255	983..1005		4/40 (10%)
		Cell attachment site. /evidence=ECO:0000255	1000..1002		1/20 (5%)
		gly_rich_SclB	<1054..>1273	CDD:468478	118/266 (44%)
		gly_rich_SclB	<1210..>1509	CDD:468478	130/313 (42%)
		Cell attachment site. /evidence=ECO:0000255	1221..1223		1/1 (100%)
		Nonhelical region 2 (NC2). /evidence=ECO:0000255	1428..1466		2/37 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1463..1541		38/85 (45%)
		Triple-helical region 1 (COL1) with 2 imperfections. /evidence=ECO:0000255	1467..1572		49/101 (49%)
		Nonhelical region 1 (NC1). /evidence=ECO:0000255	1573..1598
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.

DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col16a1

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.