DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Traf4 and Traf3

DIOPT Version :9

Sequence 1:NP_477416.1 Gene:Traf4 / 33638 FlyBaseID:FBgn0026319 Length:486 Species:Drosophila melanogaster
Sequence 2:XP_038968511.1 Gene:Traf3 / 362788 RGDID:1304633 Length:610 Species:Rattus norvegicus


Alignment Length:523 Identity:136/523 - (26%)
Similarity:206/523 - (39%) Gaps:162/523 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 DELRKLKGHLNACKHDATQCPN----------------KCGAQIPRIMMTDHLQYTCTMRRTRC- 164
            |:.:..|..|..|....|:|.:                ||.|....|:.....:..|..|.... 
  Rat    91 DKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESIIKDKVFKDNCCKREILAL 155

  Fly   165 -EFCQSEFSGAGLEEH----------NGSCGQEPVYC-EAKCGQRILRGRMTLHKSKDCAKRLRR 217
             .:|::|  |.|..|.          ...|..|.:.| .|.|.:::||..:..|..|.|..|...
  Rat   156 QIYCRNE--GRGCVEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRRDLRDHVEKACKYREAT 218

  Fly   218 CAHCQREFSADTLPLHA-AQCPRAPLACPQRCDAGPIPRGELEAHLRDECQSLAVSCSFKEAGCR 281
            ||||:.:....||..|. ..||...::||.:|....:.|.||.||| .||.:...:||||..||.
  Rat   219 CAHCKSQVPMITLQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHL-SECVNAPSTCSFKRYGCV 282

  Fly   282 FKGPRQMLEAHLESNAAAHLSLM----------VAL----SSRQGQQIQML-------------- 318
            |:|..|.::||..|:|..|::|:          |:|    |..:.:.||.|              
  Rat   283 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQ 347

  Fly   319 ---------------------------------------------KSAVSKL------------- 325
                                                         ||:|..|             
  Rat   348 KEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKS 412

  Fly   326 ----------------------------------------SINYTGTLLWKITDWSAKMAEARGK 350
                                                    :.:|.|.|:|||.|:..:..||...
  Rat   413 AGQAARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMG 477

  Fly   351 DGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFE 415
            ..|.|.|.||||..:|||:.|.::|||:|.|:.||:|::..::.|||||||.|||...:|..|.:
  Rat   478 KTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMD 542

  Fly   416 QGAQSGQGGVAESFVPDPTWENFQRPSNEPDQLGFGFPRFISHELLHSRPFIKGDTVFLRVKVDP 480
            ||  |.:..:.::|.|||...:|::|:.|.: :..|.|.|::..:|.:..:||.||:|::|.||.
  Rat   543 QG--SSRRHLGDAFKPDPNSSSFKKPTGEMN-IASGCPVFVAQTVLENGTYIKDDTIFIKVIVDT 604

  Fly   481 SKI 483
            |.:
  Rat   605 SDL 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Traf4NP_477416.1 PLN03086 <109..206 CDD:178635 24/117 (21%)
zf-TRAF 233..292 CDD:424248 23/59 (39%)
MATH_TRAF4 331..479 CDD:239750 59/147 (40%)
Traf3XP_038968511.1 RING-HC_TRAF3 93..134 CDD:319554 8/40 (20%)
zf-TRAF 178..234 CDD:280357 17/55 (31%)
zf-TRAF 239..289 CDD:424248 21/50 (42%)
Smc <294..>475 CDD:224117 22/180 (12%)
MATH_TRAF3 420..605 CDD:239746 62/187 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D391991at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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