Protein Alignment capu and FMNL1

DIOPT Version :10

• Sequence 1: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_001398057.1
• Gene: FMNL1 / 752
• HGNCID: 1212
• Length: 1104
• Species: Homo sapiens
• Alignment Length: 1180
• Identity: 258/1180 - (21%)
• Similarity: 403/1180 - (34%)
• Gaps: 349/1180 - (29%)

  Fly   315 LGSGAGS------PLTPGTMEPCAAGSGSPLANGEL---FN------------------VSKAKK 352
            :|:.|||      |..|...:|.......|.| |||   ||                  ....||
Human     1 MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAA-GELEERFNRALNCMNLPPDKVQLLSQYDNEKK 64

  Fly   353 VELQNLSSRFTAAVTQTPPGV----TSSTPNESGVTGP-AGPLGATTSSPSLETQSTVIISFKSS 412
            .||.....||.   .:.||..    ..|..:..||:.. |....:.........:||.::  :..
Human    65 WELICDQERFQ---VKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQVL--REL 124

  Fly   413 QTPVQSQTNSAASENVEDDTAPLPLPPPPPGFGTPTTPLLSSNVLKKVA----SFTVEKSSAGNN 473
            :|.:::.......|.:.::...|.:                  :|:.:|    |.|.:..|..|.
Human   125 ETSLRTNHIGWVQEFLNEENRGLDV------------------LLEYLAFAQCSVTYDMESTDNG 171

  Fly   474 SSN-----------------PPNLCPTSDETTLLATPC--------------------------- 494
            :||                 ||:..|.|...|:..||.
Human   172 ASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRA 236

  Fly   495 ----SSSLTVATLPP----EIAVG----------------AAAGGVAGGAGSRRGSSYVPEKLSF 535
                .|..::....|    |||:.                ||...|.||           ..:..
Human   237 IMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGG-----------HDIIL 290

  Fly   536 AAYEKFE----GQMLIKWLISTMQSNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLD 596
            ||::.|:    .|...:.|:...::.      |:|.: |....:||.|.     |:..:.|
Human   291 AAFDNFKEVCGEQHRFEKLMEYFRNE------DSNID-FMVACMQFINI-----VVHSVEN---- 339

  Fly   597 CGFSPYEMYQWTHTEQPTTSLPLTPGKLDKVAAWPFSSTPSGIRALESASL-----ASLGAGGVA 656
            ..|..:..|::||     ..|.|...:|               |..||..|     |.|......
Human   340 MNFRVFLQYEFTH-----LGLDLYLERL---------------RLTESDKLQVQIQAYLDNIFDV 384

  Fly   657 GSLATIATASTASSDNQKTLQQ---ILKKRLLNC-----TTLAEVHAVVNELLSSVD-------- 705
            |:|........|..::.:.||:   :|.:||.:.     ..:||:...:::....::
Human   385 GALLEDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSE 449

  Fly   706 -----------EP-------PRRPSKRCVNLTELLNASEATVYEYNKTGAEGCVKSFTDAETQTE 752
                       ||       |.|||           |.|..|.|..:.|....::...||.:...
Human   450 STAMGPSRRPPEPEKAPPAAPTRPS-----------ALELKVEELEEKGLIRILRGPGDAVSIEI 503

  Fly   753 SEDCEGTCKCGQSSTKVSDNESAKEDGEKPHAVAPPP---PPPPPPLHAFVAPPPPPPPPPPPPP 814
            ......|...|.:.|......|...|  ...|..|.|   |||||||....:|...||..||..|
Human   504 LPVAVATPSGGDAPTPGVPTGSPSPD--LAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAP 566

  Fly   815 PLANYGAPPPPPPPP-PGSGSAPPPPPPAPIEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGN 878
            ||.  |:|.|||.|| ||....||||||.|....|.:||||||
Human   567 PLP--GSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPP---------------------- 607

  Fly   879 WFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEP-------P 936
                          ||               ||...||......||....|....:|       |
Human   608 --------------PP---------------PPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMP 643

  Fly   937 AANGADAPPTAPPATKEIWTEI-EETPLDNID--EFTELFSRQAIAPVSKPKELKVKRAK----S 994
            ..|.....|:  ..|..::||: :|..|..:|  :|.|.|..::..|......||.|.|:    .
Human   644 LLNWVALKPS--QITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSK 706

  Fly   995 IKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGG 1059
            ..:::..|::|:.|..|..::.:..|..||...|...:.|:.|:.:.....||.|...|......
Human   707 ATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFERE 771

  Fly  1060 DIP---LDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKL 1121
            ..|   |...::|:|..|.|....||::.:.|...|.::..||..:|..:...|..:..|:.|:.
Human   772 QRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQ 836

  Fly  1122 VFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKE--GVH 1184
            :..|:|..|||||  :.:||.|.||.|..|..|.::||.:...||||::|:. ||::..:  |.|
Human   837 ILEIVLAFGNYMN--SSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKV-IAEKYPQLTGFH 898

  Fly  1185 PLEIRLPIPEPAD---VERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKM 1246
                       :|   :::|..:..:.|...:..|.:   |.:.|       .|..:.:.....:
Human   899 -----------SDLHFLDKAGSVSLDSVLADVRSLQR---GLELT-------QREFVRQDDCMVL 942

  Fly  1247 EEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFK-- 1309
            :||:.....:|.||.......::.|...:.::..:||.       .:|..||..::.|...:|
Human   943 KEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKT-------TSPGLFFSLFSRFIKAYKKA 1000

  Fly  1310 ----DIWKKE 1315
                :.||||
Human  1001 EQEVEQWKKE 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	105/454 (23%)
FMNL1	NP_001398057.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		7/29 (24%)
		Drf_GBD	34..281	CDD:461886	43/269 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..200		7/32 (22%)
		Drf_FH3	284..>433	CDD:461885	38/195 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..474		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..635		55/179 (31%)
		FH2	633..998	CDD:396655	93/397 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1008..1037		3/3 (100%)