Protein Alignment capu and FMN1

DIOPT Version :10

• Sequence 1: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_001264242.1
• Gene: FMN1 / 342184
• HGNCID: 3768
• Length: 1419
• Species: Homo sapiens
• Alignment Length: 1471
• Identity: 379/1471 - (25%)
• Similarity: 579/1471 - (39%)
• Gaps: 385/1471 - (26%)

  Fly    41 SERRGSRVRVLSRLMGQKRIREAFLHSPKLGSSSEVNLQGAGNGSSDWIAAE--TEVEHGQLDCS 103
            ::|:|...|..:.|||:.:|..:  ||..| |.:..||         |:..|  ..:.:|.|.||
Human   177 TKRKGRGGRESAPLMGKDKICSS--HSLPL-SRTRPNL---------WVLEEKGNLLPNGALACS 229

  Fly   104 AE-----PADFHDVVSLDC-TDSLEY-------------HNCSSDECCYASNDTLTERQNRELQQ 149
            .:     |.|.......|. ..|.|.             .:|||.|   |..|.: .|....|:.
Human   230 LQRRESCPPDIPKTPDTDLGFGSFETAFKDTGLGREVLPPDCSSTE---AGGDGI-RRPPSGLEH 290

  Fly   150 RQRQHHHHHHHIHNAHESHHHYPYDRRSLCTSCSSNDSLFTDPVDELIISKHYLNTAAKEHNNPK 214
            :|.          ...|||.                     ||      .||  ..|.|:.....
Human   291 QQT----------GLSESHQ---------------------DP------EKH--PEAEKDEMEKP 316

  Fly   215 AKR---DRPLSEISVTSVDTLSPNTAKAVLELQKRCRADKLACLSLTRVTYLSIANDLQEVEEPD 276
            |||   .:|:|:: |..|..||....:.|....|                    ..:...:....
Human   317 AKRTCKQKPVSKV-VAKVQDLSSQVQRVVKTHSK--------------------GKETIAIRPAA 360

  Fly   277 RASILHDTDLLVAPNSPAESSPDEELMALQLGKKLAQVLGSGAGSPLTPGTMEPCAAGSGSPLAN 341
            .|..:...|||..|.:.|.:.........:.|.:.:|   |.||...:..::...|.|:    .|
Human   361 HAEFVPKADLLTLPGAEAGAHGSRRQGKERQGDRSSQ---SPAGETASISSVSASAEGA----VN 418

  Fly   342 GELFNVSKAKKVELQNLSSRFTAAVTQTPPGVTSSTPNESGVTGPAG-----------PLGATTS 395
            .....|.:::|::......|....|..:.|.....|.|:.....|.|           .:|..:|
Human   419 KVPLKVIESEKLDEAPEGKRLGFPVHTSVPHTRPETRNKRRAGLPLGGHKSLFLDLPHKVGPDSS 483

  Fly   396 SPSLETQSTVIISFKSSQTPVQSQ-----TNSAASENVEDDTAPLPLPPPPPGFGTPTTPLLSS- 454
            .|..:.        |....|..:.     .|||:..:....|:|:|         :|.:|.|.|
Human   484 QPRGDK--------KKPSPPAPAALGKVFNNSASQSSTHKQTSPVP---------SPLSPRLPSP 531

  Fly   455 ---NVLKKVASFTVEKSSAGNNSSNPPNLCPTSDETTLLATPC------SSSLTVATLPPEIAVG 510
               :.:.::.:...|:.:|.|:|                  ||      |..::..||.|..:..
Human   532 QQHHRILRLPALPGEREAALNDS------------------PCRKSRVFSGCVSADTLEPPSSAK 578

  Fly   511 AAAGGVAGGAGSRRGS-SYVPEKLSFAAYEKFEGQMLIKWL-------ISTMQSNPKSSSGDANQ 567
            ......|..|..|.|. ..||            |:.|.|.|       ....||.|..||.....
Human   579 VTETKGASPAFLRAGQPRLVP------------GETLEKSLGPGKTTAEPQHQSPPGISSEGFPW 631

  Fly   568 ELFNTLALQFCNN-------LKY---------VGVLKQISNEHLDCGFSPYEMYQWTHTEQPTTS 616
            :.||....:...|       |.|         :...::.||..        |:|...|.:...|.
Human   632 DGFNEQTPKDLPNRDGGAWVLGYRAGPACPFLLHEEREKSNRS--------ELYLDLHPDHSLTE 688

  Fly   617 L-PLTPGKLDKVAAWPFSSTPS-----GIRALESASLASLGAGGVAGSLATIATASTASSDNQKT 675
            . ..|||:|.  |.||...|..     |::..|:...|::               .....::::.
Human   689 QDDRTPGRLQ--AVWPPPKTKDTEEKVGLKYTEAEYQAAI---------------LHLKREHKEE 736

  Fly   676 LQQILKKRLLNCTTLAEVHAVVNELLSSVDEPPRRPSKRCVNLTELLNASEATVYEYNKTGAEGC 740
            ::.:..:..|....:...||::...|....|          ||...|        |:...|  ||
Human   737 IENLQAQFELRAFHIRGEHAMITARLEETIE----------NLKHEL--------EHRWRG--GC 781

  Fly   741 ---------------VKSFTDAETQTESE----DCEGTCKCGQSSTKVS--------DNESAKED 778
                           .|:|.:...||:.|    .||...|..:|:..|.        ...|...|
Human   782 EERKDVCISTDDDCPPKTFRNVCVQTDRETFLKPCESESKTTRSNQLVPKKLNISSLSQLSPPND 846

  Fly   779 GEKPHA--------------VAPPPP---PPPPPLHA---FVAPPPPPPP----PPPPPPPLANY 819
            .:..||              ..||||   ||||||.:   .::|.||.||    ||.||||
Human   847 HKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPP---- 907

  Fly   820 GAPPPPPPPPPGSGSAPPPPPPAPIEGG------GGIPPPPPPMSASPSKTTISPAPLPDPAEGN 878
              |||||.|||.|...||||||.|:...      ||.||.|||           |...|.|..|.
Human   908 --PPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPP-----------PGLAPPPPPGL 959

  Fly   879 WF----HRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAAN 939
            :|    ..:...||.|:.|..||:|||||||..|              |.::|
Human   960 FFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQIS--------------DRSQN------------ 998

  Fly   940 GADAPPTAPPATKEIWTEIEETPLDNIDEFTELFSR----QAIAPVSKPKELKVKRAKSIKVLDP 1000
                      ||..:|..:||..:.:..||..|||:    |...|:|:..|.|.|..|.||:||.
Human   999 ----------ATPTLWDSLEEPDIRDPSEFEYLFSKDTTQQKKKPLSETYEKKNKVKKIIKLLDG 1053

  Fly  1001 ERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKE----AAGGDI 1061
            :||:.|||:..|||:...:|:.||:::|.|||.||.|..:...:|.||||.:|::    :...::
Human  1054 KRSQTVGILISSLHLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEEL 1118

  Fly  1062 P-LDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSI 1125
            . ||.|||||.:::.|...:||..||:|::.|.|.:|.|.||:|.:::.|:.|:..:.:|.:.::
Human  1119 KLLDKPEQFLHELAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILAL 1183

  Fly  1126 ILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRL 1190
            ||..|||||||||.||||||::|:||.|||||||:::...|:.::|:.|:....:|......: .
Human  1184 ILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSV-F 1247

  Fly  1191 PIPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADK 1255
            |:|||.|...|:|:.||::.:.:..|.::....::....|...|..|.::|||.|:|||.:.|.|
Human  1248 PLPEPQDFFLASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKK 1312

  Fly  1256 SMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIWKKEITSLL 1320
            ........|:..:..|..|:|::...||:..   .:.||...|..|..|.:|||.|||:|..::.
Human  1313 EHKMEESHLENAQKSFETTVRYFGMKPKSGE---KEITPSYVFMVWYEFCSDFKTIWKRESKNIS 1374

  Fly  1321 NELMKKSKQ--AQIESRRNVSTKVEKSGRISLKERMLMRRS 1359
            .|.:|.:::  :::.|.:.|.|| :.:...|||||:..:.:
Human  1375 KERLKMAQESVSKLTSEKKVETK-KINPTASLKERLRQKEA 1414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	153/435 (35%)
FMN1	NP_001264242.1	Microtubule-binding. /evidence=ECO:0000250	1..622		113/574 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..194		6/16 (38%)
		PHA03307	222..>633	CDD:223039	101/528 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..331		23/112 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..641		67/371 (18%)
		Mediates interaction with alpha-catenin. /evidence=ECO:0000250	456..842		87/477 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..711		9/27 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	859..978		52/135 (39%)
		FH2	973..1370	CDD:214697	153/436 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1390..1419		9/26 (35%)