Protein Alignment capu and frl-1

DIOPT Version :10

• Sequence 1: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_497505.4
• Gene: frl-1 / 175346
• WormBaseID: WBGene00021698
• Length: 1200
• Species: Caenorhabditis elegans
• Alignment Length: 1316
• Identity: 285/1316 - (21%)
• Similarity: 472/1316 - (35%)
• Gaps: 343/1316 - (26%)

  Fly   183 SSNDSLF-TDPVDELIISKHYLNTAAKEHN-------NPKAKRDRP------LSEISVTSVDTLS 233
            |:::||. |..:....:|:...|.:.|...       .||.|::.|      |...:.||.|..|
 Worm     7 STSESLSETSEIRRKAVSEDLQNESFKRTKLRRTFGVKPKKKKEDPGGSANSLRRSNSTSSDIRS 71

  Fly   234 PNTAKAVLELQKRCRADKLACLSLTRVTYLSIANDLQEVEEPDRA--SILHDTDLLVAPNSPAES 296
            ...:..:  ..:.|.         |.:...::|..:...|:.|:.  .:|...||
 Worm    72 RRISSVI--QSRECS---------TMIVGPTVAPPMPPQEQLDKMFDDVLKHMDL---------- 115

  Fly   297 SPDEELMALQ---LGKKLAQVLGSGAGSPLTP--------------------------GTMEPCA 332
             |.::|..|:   ..||...::.......:||                          |..|.
 Worm   116 -PVDKLRILRGYDNDKKWKLIVDQQVAKQVTPPAKYLEKLSYFLDKKLLKKALKNKEIGVDET-- 177

  Fly   333 AGSGSPLANGEL----------FNVSKAKKVELQNLSSRFTAAVTQTPPGVTSSTPNESGVTGPA 387
              |.|.|.:.|:          |.......:.|:.|.......:....|.|.|::   ||:  ||
 Worm   178 --STSVLRHIEISLRTNSVDWVFEFLNTPNLGLRKLVDYMRTLLADCAPSVPSTS---SGL--PA 235

  Fly   388 GPLGATTSSP--SLETQSTVIISFKSSQTPVQSQTNSAASENVEDDTAPLPLPPPPPGFGTPTTP 450
            |.|.:|.:|.  :....|::..|...:.:...|.|.:|.:.|..|.||
 Worm   236 GFLNSTANSSVGANNNHSSLNESPSHNSSYEMSTTTTANTSNSFDATA----------------- 283

  Fly   451 LLSSNVLKKVASFTVEKSSAG---------------------NNSSNPPNLCPTSDET-TLLATP 493
                |:||| ...|:.|....                     ||......:...:|.. .::.:.
 Worm   284 ----NLLKK-GPLTISKGKVAKTTGEAVDDIHICMMCLRAIMNNKQGFQQVFADTDAIYCIVRSI 343

  Fly   494 CSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFEGQMLIK---WLISTMQ 555
            ...:|...||..::.  ::...|.||           ::|...|:::||......   |.:....
 Worm   344 LHQNLRTKTLVLQML--SSICWVQGG-----------QELVSDAFDRFEKDFREPRRFWTLMQFV 395

  Fly   556 SNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWTHTEQPTTSLPLT 620
            |:|.....:     |.:.|:||.  ..:|.|.......||.     |||          |.|.|.
 Worm   396 SHPPEFHVE-----FLSSAVQFF--YYFVNVDDLNFRVHLQ-----YEM----------TLLGLD 438

  Fly   621 PGKLDKVAAWPFSSTPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQILKKRLL 685
            . .:|.:|......       |:...::....|        |.........||||......:|:|
 Worm   439 K-YIDMMAECESDE-------LQERMISYQNNG--------IDVQQLLDDSNQKTELLDENERIL 487

  Fly   686 NCTTLAE--VHAVVNELLSSVDEPPRRPSKRCVNLTELLNASEATVYEY-NKTGAEGCVKSFTDA 747
            :..:.|:  :..|..:.::......||       |.:|:...|:...|| .:.|:  ..|:..:.
 Worm   488 SQLSQAKERIQEVEAKWITDKAALDRR-------LFDLVKERESMEKEYVEEKGS--WTKTMNEK 543

  Fly   748 ETQTESE---------DCEGTCKCGQSSTKVSDNESAKEDGEKPHAVAPPPPPPPPPLHAFVAP- 802
            :.|...|         :.|...|..|:..:|...:.|........|...||.||||      ||
 Worm   544 DRQAREERKRLEQKIGELEAIQKQMQAGLQVQQQQQAAAAAAAAAAQKSPPTPPPP------APG 602

  Fly   803 ------------PPPPPPPP----PPPPPLA--------NYGAPPPPPPPPPG--SGSAPPPPPP 841
                        ||.|.|||    |||||:|        |...|||||||.|.  ||:.||||||
 Worm   603 PHKEQRRSTSKDPPRPAPPPVSSIPPPPPIAGLLAANGTNVPIPPPPPPPLPQNLSGAPPPPPPP 667

  Fly   842 APIEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMRP-LYWTRI 905
            .|:.||   ||||||          .|..|..||..:    ..|::|  :...|...| |.||
 Worm   668 PPMLGG---PPPPPP----------PPGGLMGPASND----AKTIKK--IYQTKNKLPQLNWT-- 711

  Fly   906 VTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWTEIEETPLDNIDEFT 970
                  |.:|....|:.....|     ||                     ..||:.....::|..
 Worm   712 ------AMKPMQAKNTVFEKLN-----DE---------------------LIIEKLDFSKLEEMF 744

  Fly   971 ELF----------SRQA----IAPVSKPKELKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIE 1021
            :|.          |.|:    ::|.|.........|:...:||.:|.:||.|..|.:.:.:..|.
 Worm   745 KLAQPTLGLAEPKSEQSVIGQVSPGSTTSAAGTSSARKNTLLDTKRLQNVAITRRKVAMDAKSIM 809

  Fly  1022 HAIYHIDTSVVSLEALQHMSNIQATEDEL-----QRIKEAAGGDIPLDHPEQFLLDISLISMASE 1081
            .|::.::.|.:|.|.:..:|.|..|::|.     ::..|:......|...:.|:..:..|.....
 Worm   810 AAVHQLNLSALSAEKVDILSRILPTDEERKLYAGKKTTESENSMENLSEDDNFVAALCEIERLEH 874

  Fly  1082 RISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGF 1146
            :::.:...:||:||..||..:...|:..|:...|::....|..:||..|||||.|  :||.|.||
 Worm   875 KLAVMRVMSEFDESAGLLEPQFTHVTAASKCAREAQLFHGVLEVILAFGNYMNSG--KRGGAYGF 937

  Fly  1147 NLDILGKLKDVKSKESHT-TLLHFIVRTYIAQRRKEGVHPLEIRLPIPEPADVERAAQMDFEEVQ 1210
            .|..|..|..:|:....: ||||.||    |:..|...|   ::....:...|::|..:.::.||
 Worm   938 KLSSLDSLAILKAPADRSLTLLHMIV----AEIEKNLPH---LKTFSEQLKFVDKATSVQWDSVQ 995

  Fly  1211 QQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETM 1275
            ..:.:|...|...:: ..::.....||.:..|.:..::       .||.|.|:.......|.:..
 Worm   996 TDMKELAAGFKMAEK-EQELKGTDCPEALSTFTASRKQ-------KMADLEQAFQLAASSFKDCC 1052

  Fly  1276 RFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIWKKEITSLLNELMKKSKQAQIESRRNVST 1340
            .||..:.|:       .:|..||:...:|..:::   |....:.....::|.:|.:.|.|..|::
 Worm  1053 EFYGENEKS-------TSPTVFFQKLAHFVQNYQ---KCRGENEAKAALEKRRQEEAERRARVAS 1107

  Fly  1341 KVEKSGRISLKERMLM 1356
              .||...|.:::::|
 Worm  1108 --TKSSASSEQDQLMM 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	99/447 (22%)
frl-1	NP_497505.4	Drf_GBD	94..362	CDD:461886	53/311 (17%)
		Drf_FH3	366..561	CDD:461885	47/252 (19%)
		FH2	695..1079	CDD:396655	98/443 (22%)