Protein Alignment capu and FMNL2

DIOPT Version :10

• Sequence 1: NP_001137784.1
• Gene: capu / 33611
• FlyBaseID: FBgn0000256
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: XP_054196315.1
• Gene: FMNL2 / 114793
• HGNCID: 18267
• Length: 1100
• Species: Homo sapiens
• Alignment Length: 1042
• Identity: 229/1042 - (21%)
• Similarity: 386/1042 - (37%)
• Gaps: 287/1042 - (27%)

  Fly   402 QSTVIISFKSSQTPVQSQTNSAA--SENVEDDTAPLPLPPP-------------------PPGFG 445
            |..|...|:|.::.|:|..:.:.  |.::||......||.|                   |....
Human   144 QYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRT 208

  Fly   446 TPTTPLLSSN--------VLKKVASF------------TVEKSSAGNNSSNPPNLCPTSDETTLL 490
            ...:.|:|..        .|:.:.::            .|.:.:...|:.||.......:   ||
Human   209 LKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLE---LL 270

  Fly   491 ATPCSSSLTVATLPPEIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFEGQMLIKWLISTMQ 555
            |..|.                    |.||           .::..:|::.|:.....|.....:.
Human   271 AAVCL--------------------VRGG-----------HEIILSAFDNFKEVCGEKQRFEKLM 304

  Fly   556 SNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWT------------ 608
            .:.::...:.:   |...::||.|.:.:       |.|  |..|..:..|::|
Human   305 EHFRNEDNNID---FMVASMQFINIVVH-------SVE--DMNFRVHLQYEFTKLGLDEYLDKLK 357

  Fly   609 HTEQPTTSLPLTPGKLDKVAAWPFSSTPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQ 673
            |||.....:.: ...||.|    |.                      .|:|...|....|:.:..
Human   358 HTESDKLQVQI-QAYLDNV----FD----------------------VGALLEDAETKNAALERV 395

  Fly   674 KTLQQILKKRLLNCTTLAE-VHAVVNELLSSVDEPPRRPSKRCVNL---TELLNASEATVYEYNK 734
            :.|::       |.:.|:| :....||.:|.:.|..::..:|...|   .|:...:...|:...|
Human   396 EELEE-------NISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHTLRK 453

  Fly   735 --TGAEGCVKSFTDAETQTESEDCEGTCK-------------------CGQSSTKVSDNESAKED 778
              ...|..::..:..|.:....:.:||.|                   ....|..|:.|......
Human   454 MVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTM 518

  Fly   779 GEKPHAVAPPPPPPPPP--------LHAFVAPPPPPPPPPPPPPPLANYGAPPPPPPPPPGSGSA 835
            |.......||||||.||        .:..|.||.|||||||||||      |||||||||
Human   519 GAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPP------PPPPPPPPP----- 572

  Fly   836 PPPPPPAPIEGGGGIPPPP--------PPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVN 892
            ||.|.||    ...:|.||        ||:..:.|.|.:..:.|.|          ..::..:|.
Human   573 PPLPGPA----AETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAD----------GPIKLFSVK 623

  Fly   893 PPKPMR-----PLY-WTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPAT 951
            ..||::     |:: |..:                            :|...||.
Human   624 IKKPIKTKFRMPVFNWVAL----------------------------KPNQINGT---------- 650

  Fly   952 KEIWTEIEETPL--D-NIDEFTELFSRQAIAPV----SKPKELKVKRAKSIKVLDPERSRNVGII 1009
              ::.||::..:  | |:|||.|:|..:|..|.    |..:::..|.:..:.:|:..|::|:.|.
Human   651 --VFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAIT 713

  Fly  1010 WRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGGDIPLDH---PEQFLL 1071
            .|.....:.||..||:..|...:.::.::.:.....||:|::.::.......||::   .::|::
Human   714 LRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMM 778

  Fly  1072 DISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGG 1136
            ..|.|....::::.:.|...|.||:.:|..:|..:...|..:..|:.||.:..|||.||||||
Human   779 QFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMN-- 841

  Fly  1137 NRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRLPIPEPADVERA 1201
            :.:||...||.|..|..|.|.||.:...||||     ||:...||..|  ::.|...|...||:|
Human   842 SSKRGAVYGFKLQSLDLLLDTKSTDRKQTLLH-----YISNVVKEKYH--QVSLFYNELHYVEKA 899

  Fly  1202 AQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADKSMAKLHQSLDE 1266
            |.:..|.|...:.:|.:   |...|       .|...|....:.::||:...:..:.||......
Human   900 AAVSLENVLLDVKELQR---GMDLT-------KREYTMHDHNTLLKEFILNNEGKLKKLQDDAKI 954

  Fly  1267 CRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIWKKEITSLLNELMKKSKQAQ 1331
            .:|.|.:.::::..:||.       ..|..||..:..|...:|...::      |||.||.:||.
Human   955 AQDAFDDVVKYFGENPKT-------TPPSVFFPVFVRFVKAYKQAEEE------NELRKKQEQAL 1006

  Fly  1332 IE 1333
            :|
Human  1007 ME 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	103/442 (23%)
FMNL2	XP_054196315.1	Drf_GBD	23..275	CDD:461886	23/133 (17%)
		Drf_FH3	278..475	CDD:461885	41/253 (16%)
		FH2	624..975	CDD:396655	97/416 (23%)