Protein Alignment Shaw and KCNK15

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_071753.2
• Gene: KCNK15 / 60598
• HGNCID: 13814
• Length: 330
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 83/416 - (19%)
• Similarity: 127/416 - (30%)
• Gaps: 173/416 - (41%)

  Fly   133 AVLDRLDLDTEKPSEE-------ELARKFGFE-EDYYKGTISWWQEMKPRIWSLFDEPYSSNAAK 189
            ||.|.|:.:.|...:.       .|.|||||. |||        :|:: |: :|..||:  .|.:
Human    24 AVFDALESEAESGRQRLLVQKRGALRRKFGFSAEDY--------RELE-RL-ALQAEPH--RAGR 76

  Fly   190 TIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCN 254
            .......|:..|::::                 |::..:.:.|     |.:......||
Human    77 QWKFPGSFYFAITVIT-----------------TIEYGHAAPG-----TDSGKVFCMFY------ 113

  Fly   255 AWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMR 319
                                           |.|.  |.|.|..|.|..|..:     :::|  |
Human   114 -------------------------------ALLG--IPLTLVTFQSLGERLN-----AVVR--R 138

  Fly   320 LFKLTRHSSGLK-ILIQTFRASAKELTLLVFFLVLGIVIFASL-------VYYAERIQPNPHNDF 376
            |....:...||: ..:.|.......|......|.||.|.|:..       .||
Human   139 LLLAAKCCLGLRWTCVSTENLVVAGLLACAATLALGAVAFSHFEGWTFFHAYY------------ 191

  Fly   377 NSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGA-------------LCALAGVLTIALPVPVIV 428
                    :..:|:||:|:||     ::.:..|.             |..|.|:..|...:.::|
Human   192 --------YCFITLTTIGFGD-----FVALQSGEALQRKLPYVAFSFLYILLGLTVIGAFLNLVV 243

  Fly   429 SNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAP---------------GGVS-------- 470
            ..|.:      |.|..|::..|.      ..||.||||               |..|
Human   244 LRFLV------ASADWPERAART------PSPRPPGAPESRGLWLPRRPARSVGSASVFCHVHKL 296

  Fly   471 -GCGTP--GSGPHSGP-MGSGGTGPR 492
             .|...  |..|.|.| :..||..||
Human   297 ERCARDNLGFSPPSSPGVVRGGQAPR 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	1/1 (100%)
		Ion_trans	188..439	CDD:459842	42/271 (15%)
		PRK14959	<418..>585	CDD:184923	24/102 (24%)
KCNK15	NP_071753.2	Ion_trans_2	<73..132	CDD:462301	16/119 (13%)
		Ion_trans_2	177..243	CDD:462301	14/90 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..276		7/25 (28%)