Protein Alignment Shaw and kcna4

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_005169005.1
• Gene: kcna4 / 559036
• ZFINID: ZDB-GENE-121127-2
• Length: 667
• Species: Danio rerio
• Alignment Length: 531
• Identity: 196/531 - (36%)
• Similarity: 267/531 - (50%)
• Gaps: 132/531 - (24%)

  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKL 89
            |||:||.|::.||...||.:.|.|.|....:....:||:.|||||||:...|..:|.:|:: |:|
Zfish   206 RVVINVSGLKFETQLKTLAQFPDTLLGDPEKRSRYFDPLRNEYFFDRNRPSFDAILYFYQSGGRL 270

  Fly    90 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKF 154
            ..|.:|...:|.||::|:.|....:        .:.|:.:..:.       :.|||..|:
Zfish   271 KRPVNVPFDIFSEEVKFYELGDEAM--------LKFREDEGFVK-------EEEKPLPED----- 315

  Fly   155 GFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMR---- 215
                           |.|.:||.||:.|.||:.|:.|.||||..|.|||:.|||:|.|:.|
Zfish   316 ---------------EFKRQIWLLFEYPESSSPARGIAVVSVLVIVISIVIFCLETLPEFRDDKE 365

  Fly   216 --VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSS 278
              :|           |.|....|...|..:..||.:|.||..||:|||:|||.:||:|.:|.|:.
Zfish   366 FLIP-----------GKNSTQADNGFTPFNDPFFIVETVCIIWFSFEIIVRFFASPSKADFFKNV 419

  Fly   279 VNIIDYIATLSFYI----DLVLQR--------FASHLENADILEFFSIIRIMRLFKLTRHSSGLK 331
            :|.||.::.|.::|    ||..|:        ||       ||....::|:.|:|||:|||.||:
Zfish   420 MNTIDIVSILPYFITLGTDLAQQQGNGQQAMSFA-------ILRIIRLVRVFRIFKLSRHSKGLQ 477

  Fly   332 ILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYG 396
            ||..|.|||.:||.||:||||:|:::|:|.||:||..:|.  :.|.|||...|||:|||||||||
Zfish   478 ILGHTLRASMRELALLIFFLVIGVILFSSAVYFAEADEPT--SQFTSIPDAFWWAVVTMTTVGYG 540

  Fly   397 DMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY-----SHTQARAKLPKKRRRVLPVEQ 456
            ||.|.|..|..||:|||:|||||||||||||||||..:|     :..||.|           |||
Zfish   541 DMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDNEDQAPA-----------VEQ 594

  Fly   457 PRQPRLPGAP----------GGVSG---------------------CGTPGSGPHSGPMGSGGT- 489
            |.    ||.|          |..||                     ||    |....|....||
Zfish   595 PP----PGCPYFPDFLRKFKGSPSGSSLGDKAAEYMEMEEGVTESLCG----GDTQSPSRGNGTD 651

  Fly   490 --GPRRMNNKT 498
              |....:::|
Zfish   652 LGGKNSSHSRT 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	35/109 (32%)
		Ion_trans	188..439	CDD:459842	127/273 (47%)
		PRK14959	<418..>585	CDD:184923	36/120 (30%)
kcna4	XP_005169005.1	K_channel_TID	1..>21	CDD:429748
		BTB_POZ	205..331	CDD:453885	46/159 (29%)
		Ion_trans	382..582	CDD:459842	106/208 (51%)