Protein Alignment Shaw and KCNK10

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_612190.1
• Gene: KCNK10 / 54207
• HGNCID: 6273
• Length: 543
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 53/296 - (17%)
• Similarity: 99/296 - (33%)
• Gaps: 117/296 - (39%)

  Fly   175 IWSLFDEPYSSNAAKTIGVVSVFF----ICIS------ILSFCLKTHPDMRVPIVRNITVKTANG 229
            ::...::|:.|:...||.:....|    :|:|      ::...|........||     ..::|.
Human    94 VFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPI-----GNSSNN 153

  Fly   230 SNGWFLDKTQTNAHIAFFY---------------------IECVCNAWFTFEILVRFISSPNKWE 273
            |:.|.|..       |||:                     |.|:..|.|...:          :.
Human   154 SSHWDLGS-------AFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPL----------FG 201

  Fly   274 FIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFR 338
            |:.:.:.  |.:.|:          |..           ||.|:.::|:..:.|.....:|.|
Human   202 FLLAGIG--DQLGTI----------FGK-----------SIARVEKVFRKKQVSQTKIRVIST-- 241

  Fly   339 ASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIP-----LGLWWALVTMTTVGYGDM 398
                     :.|::.|.::|.::          |...|..|.     ..:::.:||:||||:||.
Human   242 ---------ILFILAGCIVFVTI----------PAVIFKYIEGWTALESIYFVVVTLTTVGFGDF 287

  Fly   399 A--------------PKTYIGMFVGALCALAGVLTI 420
            .              |..:..:.|| |...|.||::
Human   288 VAGGNAGINYREWYKPLVWFWILVG-LAYFAAVLSM 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723
		Ion_trans	188..439	CDD:459842	51/283 (18%)
		PRK14959	<418..>585	CDD:184923	1/3 (33%)
KCNK10	NP_612190.1	Ion_trans_2	<153..211	CDD:462301	12/76 (16%)
		Ion_trans_2	249..328	CDD:462301	19/85 (22%)