Protein Alignment Shaw and KCNF1

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_002227.2
• Gene: KCNF1 / 3754
• HGNCID: 6246
• Length: 494
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 165/523 - (31%)
• Similarity: 242/523 - (46%)
• Gaps: 98/523 - (18%)

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALA-----------NYDPILNEYFFDRHPGVFAQV 80
            :|:||||:|...|...|.:.|.|||:.|...||           :|||...|::|||.|..|..|
Human    25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCV 89

  Fly    81 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLA-----VLDRLDL 140
            :..|..|::|....:|...|:.|::||.:|...::.||....::.|:..|.:|     :||.|.:
Human    90 IEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGV 154

  Fly   141 DTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILS 205
            |..:                     ..|:..:..:|...::|.||..|:.:.|:|...|.:|.:.
Human   155 DAAE---------------------GRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVV 198

  Fly   206 FCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNA-HIAFFYIECVCNAWFTFEILVRFISSP 269
            .|:.|.|:::|                  ||...... |.....:|..|..|||.|.|:|..|||
Human   199 MCMGTIPELQV------------------LDAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSP 245

  Fly   270 NKWEFIKSSVNIIDYIATLSFYIDLVLQRFAS---HLENA-DILEFFSIIRIMRLFKLTRHSSGL 330
            ||..|..|.:||:|.:|.|.||:.|.|....:   .|.|. ..::...|:||.|:|||.||||||
Human   246 NKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGL 310

  Fly   331 KILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGY 395
            :.|....:.|.|||.||:.:|.:||.:|::|.|..|  |.:|...|.|||...|||::|||||||
Human   311 QTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTME--QSHPETLFKSIPQSFWWAIITMTTVGY 373

  Fly   396 GDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQP 460
            ||:.|||.:|....|:..|.||:.||||:..|::||..||:           ::|||......:.
Human   374 GDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYN-----------KQRVLETAAKHEL 427

  Fly   461 RLPGAPGGVSGCGTPGSGPHSGPMGSGGTGPRRMNNKTKDLVSPKSVAQLFAGPLGASIVAMSPR 525
            .|...              :|...|.|.||..|.:   .|.:.|:        |.|....:.|.|
Human   428 ELMEL--------------NSSSGGEGKTGGSRSD---LDNLPPE--------PAGKEAPSCSSR 467

  Fly   526 TML 528
            ..|
Human   468 LKL 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	39/123 (32%)
		Ion_trans	188..439	CDD:459842	100/255 (39%)
		PRK14959	<418..>585	CDD:184923	26/111 (23%)
KCNF1	NP_002227.2	BTB_POZ_Kv5_KCNF1	23..138	CDD:349690	37/112 (33%)
		Ion_trans	181..417	CDD:459842	100/266 (38%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..469		12/46 (26%)