Protein Alignment Shaw and KCND3

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_004971.2
• Gene: KCND3 / 3752
• HGNCID: 6239
• Length: 655
• Species: Homo sapiens
• Alignment Length: 701
• Identity: 198/701 - (28%)
• Similarity: 305/701 - (43%)
• Gaps: 199/701 - (28%)

  Fly    12 AHAAMNLINMDSENR----VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDR 72
            |:..|.|...|...|    :||||.|.|.:|::.||::.|.|.|.. ||....::....||||||
Human    23 ANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEDTKEYFFDR 86

  Fly    73 HPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDR 137
            .|.||..|||:|||||||||...|...:::||.|:|:....:..||   |.:::|.:...|  :|
Human    87 DPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCC---YEEYKDRKRENA--ER 146

  Fly   138 LDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICIS 202
            |..|.:..:.:|......|.:               .:|..|:.|::|..|.....|:.|||.:|
Human   147 LMDDNDSENNQESMPSLSFRQ---------------TMWRAFENPHTSTLALVFYYVTGFFIAVS 196

  Fly   203 ILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFIS 267
            :::..::|.|...||           ||......:..:   :|||.::..|...||.|.|:|..:
Human   197 VITNVVETVPCGTVP-----------GSKELPCGERYS---VAFFCLDTACVMIFTVEYLLRLFA 247

  Fly   268 SPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSG 329
            :|:::.||:|.::|||.:|.:.:||.||:      ..|.|:...|   .:.|:.|:||.:|||.|
Human   248 APSRYRFIRSVMSIIDVVAIMPYYIGLVM------TNNEDVSGAFVTLRVFRVFRIFKFSRHSQG 306

  Fly   330 LKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVG 394
            |:||..|.::.|.||..|:|.|.:.|:|||::::|||:  .:..:.|.|||...|:.:|||||:|
Human   307 LRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPASFWYTIVTMTTLG 369

  Fly   395 YGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFA-MYYSHTQARAKLPKKRRRVLPVEQPR 458
            ||||.|||..|...|::|:|:|||.||||||||||||: :|:.:.:|..:..:|:.|:..:.
Human   370 YGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIR--- 431

  Fly   459 QPRLPGAPGGVSGCGTPGSGPHSGPMG-------SGGTGPRRMNNKTKDLVSPK----------- 505
                      |:..|:..:..||...|       ..||.......||..|:..:
Human   432 ----------VAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKT 486

  Fly   506 -SVAQLFAGPL------------------------------------------------------ 515
             .::.|...||
Human   487 TGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHPGLTTTCCSRRS 551

  Fly   516 -------GASIVAMSPRTMLDLN---------PALAMGKPTFQPR-------------------- 544
                   .:::.|...|:|.:|:         |:|...:.:...:
Human   552 KKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIIS 616

  Fly   545 IPTPLAATP-----PPPVSSAGGMTASGIGTTSATGATSAPQPATPLPSIA 590
            ||||.|.||     |||.|                     |.|.|.:||||
Human   617 IPTPPALTPEGESRPPPAS---------------------PGPNTNIPSIA 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	46/114 (40%)
		Ion_trans	188..439	CDD:459842	99/254 (39%)
		PRK14959	<418..>585	CDD:184923	49/281 (17%)
KCND3	NP_004971.2	BTB_POZ_KCND3	6..143	CDD:349726	49/123 (40%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34997220	6..21
		Interaction with KCNIP1. /evidence=ECO:0000269|PubMed:17187064	70..78		1/7 (14%)
		Ion_trans	186..412	CDD:459842	98/247 (40%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		3/4 (75%)
		DUF3399	468..563	CDD:463381	5/94 (5%)
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000269|PubMed:34997220	470..487		1/16 (6%)
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	472..487		0/14 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..565		0/39 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..655		18/53 (34%)