Protein Alignment Shaw and Kcns2

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_851834.1
• Gene: Kcns2 / 16539
• MGIID: 1197011
• Length: 477
• Species: Mus musculus
• Alignment Length: 427
• Identity: 137/427 - (32%)
• Similarity: 222/427 - (51%)
• Gaps: 38/427 - (8%)

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVF 77
            |.|.|:  ||||.:......||.:.|.|||.||         .|...:||.:..|::|||:|.:|
Mouse    16 DGEIRI--NVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78

  Fly    78 AQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDT 142
            ..||::|.|||||...::|...|.:|:|:||::...::.||..:|...:...|.....::.|.::
Mouse    79 PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQES 143

  Fly   143 EKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFC 207
            ...|.:|:   ..|..|..|.........:.::|...|.|..|..::...|:|:..:..||::.|
Mouse   144 TTSSFDEI---LAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMC 205

  Fly   208 LKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKW 272
            |.:.||.::|        .:.|:.|         ....|..:|....||||||::.||..:|:..
Mouse   206 LNSLPDFQIP--------DSQGNPG---------EDPRFEIVEHFGIAWFTFELVARFAVAPDFL 253

  Fly   273 EFIKSSVNIIDYIATLSFYIDLVLQ---RFASHLEN-ADILEFFSIIRIMRLFKLTRHSSGLKIL 333
            :|.|:::|:||.::.:.|||.||:.   ..:..|.| ..:.:...::||.|:.||.|||:||:.|
Mouse   254 KFFKNALNLIDLMSIVPFYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSL 318

  Fly   334 IQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDM 398
            ..|.:.|.||:.||:.:|.:||.||:.:.|   .|:...:....:||...|||.|:||||||||:
Mouse   319 GATLKYSYKEVGLLLLYLSVGISIFSVVAY---TIEKEENEGLATIPACWWWATVSMTTVGYGDV 380

  Fly   399 APKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            .|.|..|....:.|.|||:|.:.||:.:|.:.|:.:|
Mouse   381 VPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFY 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	41/119 (34%)
		Ion_trans	188..439	CDD:459842	85/252 (34%)
		PRK14959	<418..>585	CDD:184923	6/18 (33%)
Kcns2	NP_851834.1	BTB_POZ_KCNS2	18..124	CDD:349734	39/107 (36%)
		Ion_trans	186..421	CDD:459842	85/252 (34%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)