Protein Alignment Shaw and Kcns1

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_032461.2
• Gene: Kcns1 / 16538
• MGIID: 1197019
• Length: 497
• Species: Mus musculus
• Alignment Length: 442
• Identity: 138/442 - (31%)
• Similarity: 226/442 - (51%)
• Gaps: 54/442 - (12%)

  Fly    29 LNVGGIRHETYKATLKKIPATRLSRLTEALA---------NYDPILNEYFFDRHPGVFAQVLNYY 84
            :||||:|.......|.:.|.|||.||..|.:         :||...:|::||||||.|..:|::|
Mouse    23 VNVGGVRRLLSARALARFPGTRLGRLQAAASEEQARRLCDDYDAAAHEFYFDRHPGFFLGLLHFY 87

  Fly    85 RTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPS--- 146
            |||.||...::|...|.:|.::|||..|.:..||...|.:.|     :|.....|.|::.||
Mouse    88 RTGHLHVLDELCVFAFGQEADYWGLGENALATCCRARYLERR-----VARPRAWDEDSDAPSSVD 147

  Fly   147 ---------EEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICIS 202
                     :.|||| :|         .:....::.|:|...:.|..|..:|....||:..:..|
Mouse   148 PCPDEISDVQRELAR-YG---------AARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLAS 202

  Fly   203 ILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFIS 267
            |.:.|:.:.|:.:   .|......|..:.|...::.:.:..:.  .:|..|.|||:||:..|.:.
Mouse   203 IAAMCIHSLPEYQ---AREAAAAVAAVAAGRSAEEVRDDPVLR--RLEYFCIAWFSFEVSSRLLL 262

  Fly   268 SPNKWEFIKSSVNIIDYIATLSFYIDLVL------QRFASHLENAD---ILEFFSIIRIMRLFKL 323
            :|:...|....:|:||.::.|.||:.|:.      ||.||..|..|   :::.|.::||.|:.||
Mouse   263 APSTRNFFCHPLNLIDIVSVLPFYLTLLAGAALGDQRGASGEELGDLGKVVQVFRLMRIFRVLKL 327

  Fly   324 TRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALV 388
            .|||:||:.|..|.:.|.:|:.:|:.:|.:|:.:|:.:.|.||    ..:..|::||...||..|
Mouse   328 ARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAE----EENEGFHTIPACWWWGTV 388

  Fly   389 TMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQA 440
            :||||||||:.|:|..|....:.|.|.|:|.:|||:.:|.:.|:.:|...:|
Mouse   389 SMTTVGYGDVVPETVGGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKA 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	42/114 (37%)
		Ion_trans	188..439	CDD:459842	82/259 (32%)
		PRK14959	<418..>585	CDD:184923	8/23 (35%)
Kcns1	NP_032461.2	BTB_POZ	21..126	CDD:453885	39/102 (38%)
		Ion_trans	188..439	CDD:459842	82/259 (32%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	392..397		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..497