Protein Alignment Shaw and Kcnb1

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_032446.2
• Gene: Kcnb1 / 16500
• MGIID: 96666
• Length: 857
• Species: Mus musculus
• Alignment Length: 670
• Identity: 220/670 - (32%)
• Similarity: 321/670 - (47%)
• Gaps: 155/670 - (23%)

  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPIL----------NEYFFDRHPGVFAQV 80
            ||.|||||:.||....||.::|.|||.:|.:. ..:|.:|          ||||||||||.|..:
Mouse    32 RVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDC-NTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSI 95

  Fly    81 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKP 145
            ||:||||:||...::|...|.:||::||:|...:|.||...|.|.::           .::.|..
Mouse    96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKE-----------QMNEELK 149

  Fly   146 SEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKT 210
            .|.|..|:...||  :..|..  .|.:.::|.|.::|.||.|||.:.::|:.||.:|.::..|.|
Mouse   150 REAETLREREGEE--FDNTCC--AEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNT 210

  Fly   211 HPDMRVPIVRNITVKTANGSNGWFLD---KTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKW 272
            .|:::                  .||   ::..|..:|  ::|.||.||||.|.|:||:|||.||
Mouse   211 LPELQ------------------SLDEFGQSTDNPQLA--HVEAVCIAWFTMEYLLRFLSSPKKW 255

  Fly   273 EFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEF---------FSIIRIMRLFKLTRHSS 328
            :|.|..:|.||.:|.|.:|:.:.|..     .|..:|:|         |.|:||:|:.||.|||:
Mouse   256 KFFKGPLNAIDLLAILPYYVTIFLTE-----SNKSVLQFQNVRRVVQIFRIMRILRILKLARHST 315

  Fly   329 GLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTV 393
            ||:.|..|.|.|..||.||:.||.:||:||:|||::||:.:.:  ..|.|||...|||.:|||||
Mouse   316 GLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDD--TKFKSIPASFWWATITMTTV 378

  Fly   394 GYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPR 458
            ||||:.|||.:|..||.||.:||||.||||:|:||:||:.:|.. |.|.:...|||..|  |:.:
Mouse   379 GYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QKRQEKAIKRREAL--ERAK 440

  Fly   459 QPRLPGAPGGVSGCGTPGSGPHSGPM-----GSGGTGPRRMN---------NK---TKDLVSPKS 506
            :      .|.:.......:...|..|     ...|.|..:.:         ||   ||..:|..|
Mouse   441 R------NGSIVSMNMKDAFARSIEMMDIVVEKNGEGVAKKDKVQDNHLSPNKWKWTKRALSETS 499

  Fly   507 VAQLF-AGPLGASIVAMSPRTMLDLN-----------------PALAMGK--PTFQPR------- 544
            .::.| ....|:...|.|..:...||                 |.|...:  |..||:
Mouse   500 SSKSFETKEQGSPEKARSSSSPQHLNVQQLQDMYSKMAKTQSQPILNTKEMAPQSQPQEELEMGS 564

  Fly   545 IPTPLAATPP--------------------------------PPVSS----AGGMTASGIGTTSA 573
            :|:|:|..|.                                .|::|    :||.||..:|...|
Mouse   565 MPSPVAPLPTRTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLASLSGKSGGSTAPEVGWRGA 629

  Fly   574 TGATSAPQPAT-PLPSIAVS 592
            .||:......| |:|..:.|
Mouse   630 LGASGGRLMETNPIPEASRS 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	49/118 (42%)
		Ion_trans	188..439	CDD:459842	110/262 (42%)
		PRK14959	<418..>585	CDD:184923	55/247 (22%)
Kcnb1	NP_032446.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719	49/109 (45%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	59..75		3/16 (19%)
		Ion_trans	188..424	CDD:459842	110/263 (42%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	448..481		4/32 (13%)
		Kv2channel	467..678	CDD:397541	37/183 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..569		18/93 (19%)
		FFAT. /evidence=ECO:0000250|UniProtKB:Q14721	590..596		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..627		7/18 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..802
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..857