Protein Alignment Shaw and kcnd1

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_031747765.1
• Gene: kcnd1 / 100488387
• XenbaseID: XB-GENE-6047565
• Length: 631
• Species: Xenopus tropicalis
• Alignment Length: 454
• Identity: 163/454 - (35%)
• Similarity: 242/454 - (53%)
• Gaps: 50/454 - (11%)

  Fly    21 MDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYR 85
            |.|:..:|:||.|.:.:|:|.||.:.|.|.|.. ||....::....||||||.|.:|..:||:||
 Frog    36 MKSDEILVVNVSGRKFQTWKNTLDRYPDTLLGS-TEKDFFFNQDTQEYFFDRDPEMFRHILNFYR 99

  Fly    86 TGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEEL 150
            |||||||...|...|:|||.|:|:....:..||...|...:...     |:||..||    |.|.
 Frog   100 TGKLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKEN-----LERLAEDT----EAET 155

  Fly   151 ARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMR 215
            |.......|         ...:.|:|..|:.|::|..|.....|:.|||.:|:::..::|.| .|
 Frog   156 AGDTPLPPD---------STFRQRLWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP-CR 210

  Fly   216 VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVN 280
            .|..|...:......|            :||..::..|...||||.|:|..::|::.:|::|.::
 Frog   211 PPAGRLKELPCGEKYN------------LAFVCMDTACVLIFTFEYLMRLFAAPSRCKFMRSVMS 263

  Fly   281 IIDYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAK 342
            |||.:|.:.|||.||:.      ||.::...|   .:.|:.|:||.:|||.||:||..|.::.|.
 Frog   264 IIDVVAIMPFYIGLVMP------ENENVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322

  Fly   343 ELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMF 407
            ||..|:|.|.:.|:|||::::|||:  ......|.|||...|:.:|||||:|||||.|.|..|..
 Frog   323 ELGFLLFSLTMAIIIFATVMFYAEK--GTSKTKFTSIPAAFWYTIVTMTTLGYGDMVPDTIAGKI 385

  Fly   408 VGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSG 471
            .|::|:|:|||.||||||||||||:..| |...||...:.::::      |..|:..|....:|
 Frog   386 FGSICSLSGVLVIALPVPVIVSNFSRIY-HQNQRADKRRAQQKI------RLARIRLAKSNTTG 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	42/110 (38%)
		Ion_trans	188..439	CDD:459842	99/253 (39%)
		PRK14959	<418..>585	CDD:184923	21/54 (39%)
kcnd1	XP_031747765.1	BTB_POZ_KCND1	6..143	CDD:349724	44/107 (41%)
		Ion_trans	184..415	CDD:459842	98/252 (39%)
		DUF3399	466..542	CDD:463381