DRSC/TRiP Functional Genomics Resources

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Protein Alignment: Spindly and SPDL1

Sequence 1:NP_608791.2 Gene:Spindly FlyBaseID:FBgn0031549 Length:781 Species:Drosophila melanogaster
Sequence 2:NP_001316568.1 Gene:SPDL1 HGNCID:26010 Length:622 Species:Homo sapiens

Alignment Length:602 Identity:137/603 (23%)
Similarity:249/603 (41%) Gaps:163/603 (27%)


  Fly    31 DQSEKDAQRIYELKRNLDTALAAESYLTQE-----LEHLSSQPVAIASGGNGQELEELRRKFKTL 90
            :|.:...||..|||..:..:|:.|....::     ||.|..|    .|..:|||:.||:.|.:.|
Human    56 EQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQ----LSRSHGQEVNELKTKIEKL 116

  Fly    91 KEEQDVLQQDYDAKVEETRSLKDKLTAAEKNLAEKSAS---RSNQLHDDFFARLNALELENCELL 152
            |.|.|      :|::.| :.||.::...::.|:.||..   .|.::.:...:.:.||::|     
Human   117 KVELD------EARLSE-KQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIE----- 169

  Fly   153 QKLAEYEDLRIANTLAVAEKEKTIECLQDRVSCMEQNLNCKRDELEEK----------------- 200
              |.|.|.::    ..:.|:...::..|:::..:..||..:.|.|:|:                 
Human   170 --LTEMESMK----TTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEK 228

  Fly   201 -------LQL-LESCQEQLVDANAKIALLTSAPENNDRKGNSLFAEVDDQRQAMKQILAAQKKSY 257
                   ||: |:...:|.:|.|:              |||||||||:|:|.||::.|.:.|..|
Human   229 ARVANQDLQVQLDQALQQALDPNS--------------KGNSLFAEVEDRRAAMERQLISMKVKY 279

  Fly   258 LDMKKIFTDSQFEIRRLKRENVAMHTELQACSTIFCSADK--TYQNKLNERIRQLMTANDSLERQ 320
            ..:||....::.:::|:|.: :|...:::...|.|...::  ....:.|..|:.|:....:||:.
Human   280 QSLKKQNVFNREQMQRMKLQ-IATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKF 343

  Fly   321 LNL--SQERLRQLAS---EKSVTWLDSM---LDFCKRETDELKAQLHSMRIQKAGLEERMRCVQQ 377
            .||  |.|....:.|   |.:..:.|.:   ||...:|.:..|.:|...|::  .|.|..|.:..
Human   344 KNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMK--ALFESQRALDI 406

  Fly   378 EMARWRFESLKSRCV-LIDRENL-----LAEHKIVFKPMQAMEFNIKEAELKTALPRIVSVAAQS 436
            |...:..|    ||: |.:.||:     |.|.|:.::|.:.:|..:                   
Human   407 ERKLFANE----RCLQLSESENMKLRAKLDELKLKYEPEETVEVPV------------------- 448

  Fly   437 PSSSAQLHTHPETSLKSAAETTSKSFPTATEIIVLDAPL------KPAIKEEVVEPLSQELKPAL 495
                          ||...|.......||.:..|.::.|      .|..|||     :|....:|
Human   449 --------------LKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEE-----TQSCPNSL 494

  Fly   496 KDTSVKVEQELEVSESKACIKRTPIKTIMGMKIKREIDLNLEQQDAVDIKKELEAPELIPKPQLK 560
            :|.::::|:.:.:        .||:.::...|     :|.::.|    :|||.:..:||      
Human   495 EDNNLQLEKSVSI--------YTPVVSLSPHK-----NLPVDMQ----LKKEKKCVKLI------ 536

  Fly   561 GTPVKA----KNDGVTP 573
            |.|..|    :..|.||
Human   537 GVPADAEALSERSGNTP 553

Known Domains:


GeneSequenceDomainRegion External IDIdentity
SpindlyNP_608791.2 Smc <11..336 CDD:224117 84/345 (24%)
SPDL1NP_001316568.1 GrpE 351..>417 CDD:295646 17/72 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 76 1.000 Inparanoid score I5184
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 1 0.960
User_Submission 00.000 Not matched by this tool.
22.010

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