Protein Alignment Spindly and Spdl1

DIOPT Version :10

• Sequence 1: NP_608791.2
• Gene: Spindly / 33578
• FlyBaseID: FBgn0031549
• Length: 781
• Species: Drosophila melanogaster
• Sequence 2: NP_001029310.1
• Gene: Spdl1 / 303037
• RGDID: 1306908
• Length: 597
• Species: Rattus norvegicus
• Alignment Length: 593
• Identity: 144/593 - (24%)
• Similarity: 240/593 - (40%)
• Gaps: 118/593 - (19%)

  Fly    26 HQQLKDQSEKDAQRIYELKRNLDTALAAESYLTQELEHLSSQPVAIAS-------GGNGQELEEL 83
            |:::...:|...|..|.|:|.::........|:.|.|.|..|..|...       ..:.||:..|
  Rat    44 HEEMMTTAENYNQEKYALQREVELKSRMLESLSCECEALRQQQKAQLEQLEMQLHRSHRQEVHGL 108

  Fly    84 RRKFKTLKEEQDVLQQDYDAKVEETRSLKDKLTAAEKNLAEKSASRSNQLHDDFFARLNALELEN 148
            |.|.:.||.|.|      :|::.| :.||.||....:.|:.|    |.:|.  ..:...||...:
  Rat   109 RNKLENLKVELD------EARLSE-KQLKQKLDHQGELLSHK----SEELR--LLSEQRALSSVS 160

  Fly   149 CELLQ---KLAEYEDLRIANTLAVAEKEKTIECLQDRVSCMEQNLNCKRDELEEKLQ-------- 202
            .|||.   :|.|.|.::    .|:.|:...::|.|:::.|:..:|..:.|.|:|:.:
  Rat   161 SELLSLQTELTEAEGVK----NALREEVNELQCKQEQLECLNASLLHQVDRLKEEKEEREKEAVS 221

  Fly   203 ---LLESCQEQLVDANAKI--ALLTSAPENNDRKGNSLFAEVDDQRQAMKQILAAQKKSYLDMKK 262
               .||..:.:..|...::  ||..:|..|:  |||||||||:|:|.||::.|...|..|..:||
  Rat   222 YYNALEKARVENQDLQVQLGHALQQAADPNS--KGNSLFAEVEDRRVAMERRLNLMKDKYQSLKK 284

  Fly   263 --IFTDSQFEIRRLKRENV----AMHTELQACSTIFCSADKTYQNKLNERIRQLMTANDSLERQL 321
              .||..|....:|:...:    ...||.:....:|...::.     |..|:.|:...:.||:..
  Rat   285 QNAFTRDQMNKMKLQISTLLRMRGSQTEFEQQERLFAMLEQK-----NGEIKHLLGEINKLEKFK 344

  Fly   322 NLSQERLRQLAS--------EKSVTWLDSM---LDFCKRETDELKAQLHSMRIQKAGLEERMRCV 375
            || .|.:...:|        |.|..:.|.:   ||...:|.:..|.:|...|::  .|.|..|.:
  Rat   345 NL-YENMESKSSTSDSACALEDSTYYTDLLQLKLDKLNKENESTKGELSIQRMK--ALFESQRTL 406

  Fly   376 QQEMARWRFESLKSRCVLIDRENL-----LAEHKIVFKPMQAMEFNIKEAELKTALPRIVSVAAQ 435
            ..|...:..|   ....|.:.|||     |.|.|:.::|.:.:|..:.:.. :..||..::...:
  Rat   407 DIERKLFANE---RHLQLSESENLKLRAKLDELKLKYEPEERIEVPVLKRR-REVLPLNINTPEE 467

  Fly   436 SPSSSA--------QLHTHPETSLKSAAETT-----------SKSFPTATEIIVLDAPLKPAIKE 481
            :.::||        .|....|:.|.:..:.|           .||.|..|:      |.|.....
  Rat   468 TAAASATGEDVSRLPLERKEESCLDNLKDNTVQWKQPASLSPHKSLPLDTQ------PKKEKCVT 526

  Fly   482 EVVEPLSQEL----------KPALKD-----TSVKVEQELEVSESKACIKRTPIKTIMGMKIKRE 531
            .|..|.|.|:          .|.|.:     |.||..:|......|...|::  .|||.:..|..
  Rat   527 LVASPASTEVLHEQSGNTPSSPRLTEESRLPTKVKERKEATSKLEKGASKKS--HTIMYVSSKST 589

  Fly   532 IDLNLEQQ 539
            .::...||
  Rat   590 PEMQCPQQ 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spindly	NP_608791.2	SMC_prok_B	<78..380	CDD:274008	90/334 (27%)
Spdl1	NP_001029310.1	Smc	<2..>277	CDD:440809	69/251 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..597		15/67 (22%)