Protein Alignment Spindly and spdl1

DIOPT Version :10

• Sequence 1: NP_608791.2
• Gene: Spindly / 33578
• FlyBaseID: FBgn0031549
• Length: 781
• Species: Drosophila melanogaster
• Sequence 2: NP_001123745.1
• Gene: spdl1 / 100170491
• XenbaseID: XB-GENE-5754925
• Length: 611
• Species: Xenopus tropicalis
• Alignment Length: 670
• Identity: 149/670 - (22%)
• Similarity: 254/670 - (37%)
• Gaps: 192/670 - (28%)

  Fly    31 DQSEKDAQRIYELKRNLDTALAAE-SYLTQE----LEHLSSQPVAIASGGNGQELEELRRKFKTL 90
            :|.:...||..|||..:..:|.:| ..:.|:    ||.|..|    ....:.:||.|::.|.:.|
 Frog    57 EQEKYSLQREVELKNRMLESLTSECENIRQQQKLCLEQLQEQ----LERNHHRELSEIKDKLEKL 117

  Fly    91 KEEQDVLQQDYDAKVEETRSLKDKLTAAEKNLAEKSAS---RSNQLHDDFFARLNALELENCELL 152
            |.|.|      :|::.| :.||.||....:.||.||..   .|.::|:...:.:..|:||..||.
 Frog   118 KAELD------EARLSE-KQLKHKLEYQSEVLANKSEELRMMSERVHETMSSEMLTLQLEKTELE 175

  Fly   153 QKLAEYEDLRIANTLAVAEKE---------KTIECLQDRVSCMEQNLNCKRDELEEKL---QLLE 205
            ...|..|  :..|.|...|::         :.:|.|||.          |.|..:|.:   :.||
 Frog   176 SAKANLE--QEVNELQYREQQLLLTNGTQSRQLERLQDE----------KEDREKEAVGYFKALE 228

  Fly   206 SCQEQLVDANAKIALLTSAPENNDRKGNSLFAEVDDQRQAMKQILAAQKKSYLDMKKIFTDSQFE 270
            ..:|...|..|::.:.....::.:.|||||||||:|:|..|::.|.:.|..:..::|....|:.:
 Frog   229 KAREANQDLQAQLDIALQQAQDPNSKGNSLFAEVEDRRAEMERQLISMKVQFQSLQKQHAFSRQQ 293

  Fly   271 IRRLKRENVAMHTELQACSTIFCSADKTYQNKLNERIRQLMTANDSLERQLNLSQERLRQLASEK 335
            :.|:|   |.:.|.||                        :..:.|...||    |||:.:.::|
 Frog   294 MHRMK---VQIATLLQ------------------------LKGSQSDPEQL----ERLQAMVAQK 327

  Fly   336 S---------VTWLDSMLDFCKR--------------ET---DELKAQL--HSMRIQKAGLEERM 372
            :         |..|:.....|:.              ||   |.||.:|  .|..|:|
 Frog   328 NSEFETLVMKVRQLEKSQQICENGPVANSSDGLGQGDETYYVDLLKMKLVNSSKEIEK------- 385

  Fly   373 RCVQQEMARWRFESLKSRCVLIDRENLLAEHKIVFKPMQA----MEFNIKEAELKTALPRIVSVA 433
              ::.|::..|.::|.....::|.|..|..:....|..|.    :..|:.|.::|
 Frog   386 --IKDELSLQRMKALAESQRVLDLERKLFANDRHLKLSQGENMKLRVNLDEMKMK---------- 438

  Fly   434 AQSPSSSAQLHTH----PETSLKSAAETTSKSFPTATEIIVLDAPLKPAIKEEVVEPLSQELKPA 494
             ..|...|::.|.    .:..|..|.:.||.:..:.::.    ..|..||.|::.        ||
 Frog   439 -YEPDEIAKIRTQKRRKEQLPLDCAIDNTSATVTSGSQA----HGLSDAIPEDMC--------PA 490

  Fly   495 LKDTSVKVEQELEVSESKACIKRTPIKTIMGMKIKREIDLNLEQQDAVDIKKELEAPELIPKPQL 559
                           ||          |:....:|.:..|:.::||       |.:..:.|....
 Frog   491 ---------------ES----------TVHRNLLKEDSSLSTKEQD-------LSSVAVKPIEPA 523

  Fly   560 KGTPVKAKNDGVTPQMNIQEDENEETGLNSVET---------PAKPLMKGTPVKQRLGGIKVKSN 615
            .|.|.|.:.     ::.|.|:||:...:|...|         |.....:.|...:|....:.|..
 Frog   524 NGQPPKERK-----RVRIVENENDNQDINKRNTNNCSVTSTSPRSASEESTSESKRFDEEQEKRK 583

  Fly   616 EELLGARL---PGTVTPAKP 632
            :| ..:||   |....|:||
 Frog   584 QE-RKSRLRAPPVLHVPSKP 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spindly	NP_608791.2	SMC_prok_B	<78..380	CDD:274008	84/344 (24%)
spdl1	NP_001123745.1	Smc	<2..>268	CDD:440809	66/233 (28%)
		SMC_prok_B	<158..477	CDD:274008	81/385 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	499..611		26/117 (22%)