DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and pkp1

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_012809816.1	Gene:	pkp1 / 100496099	XenbaseID:	XB-GENE-949309	Length:	753	Species:	Xenopus tropicalis

Alignment Length:	760	Identity:	195/760 - (25%)
Similarity:	316/760 - (41%)	Gaps:	139/760 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NMNSTHINMDLSLTHEPANM------------QSQFGSF---QNYDQFSAAGYSSTPLYITKPTG 63
            |||..: |.:....::.||.            |.:|.|:   .|:.|.....|:| ||
Frog    78 NMNYNN-NANQYSKYQSANSIGYQYNGTLKRDQQRFSSYSQADNWGQHRHMSYAS-PL------- 133

  Fly    64 VGAITKVAPHCSQNKIETNSTDNSIPDIENHPLATTVR----YVQ----------AGQYEDTSEY 114
                   :|....:..:|..:..|.||:....:..|:|    |.|          .|:..::|.|
Frog   134 -------SPGSDFDYKQTLKSSRSEPDLTGPDVRATLRRQNQYNQMQNQHHQQQRPGRAHNSSFY 191

  Fly   115 GVAGL---------------TCGIDSEYTAEAVVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDN 164
            .....               :.....:...:....:||     ||..|...|:.:.|: .|..||
Frog   192 SYHSTQQKKRGPMTPARTPSSLSTVQQQQQQQQQQHCY-----YTNAQRNESNFQNFN-IPKQDN 250

  Fly   165 INGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSENDICSTMRWRDPNLSE 229
                                       ..:|| ||.|::.:|::..|.            ..|..
Frog   251 ---------------------------YGTIN-VPSRMDTRDEFDAGG------------MTLDR 275

  Fly   230 VISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNL 294
            .:..|..|....:.:.|.|:||.|:.|:..|.......||..|:.||...:..:.:...||||||
Frog   276 AVELLGYPDDKFQMSGANYIQHACFQDENAKNLVYQSNGISKLINLLQSPNENVQQATAGALRNL 340

  Fly   295 SYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVC 359
            .:  :|..||......||....|.||.|:...::::.:||:|||:||.:.||..::.|||..:..
Frog   341 VF--KNSANKLETSQKGGTREAVSLLKRTSHPDIQKQLTGLLWNLSSSDQLKDELVKEALPVLNE 403

  Fly   360 SVIKPHSGW-DAVCCGETCF--STVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSI 421
            .|:.|:||| :.....:.|.  ..||.||:|.|||:||| :..|..:|||..||:.|::.::..:
Frog   404 RVVIPYSGWSERSMSNQNCMLDPEVFFNATGCLRNLSSA-DVGRKAMRNCPGLVDSLMFYIQKCL 467

  Fly   422 EKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEA 486
            ......:|:||||.|||.||||.. :.:.||  |:..:..:......:.....||| :||.:|..
Frog   468 ANKCPDDKSVENCACILHNLSYHL-DSEVPN--KYSQLDEQMYRLQQNDKTTTGCF-SNKSEKLQ 528

  Fly   487 NNSDALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLS 551
            ||:..|......|:           .||...|.....::.|||||:......||||.|||:|||:
Frog   529 NNNFQLPLPEEDAN-----------PKGAALLSHSSAIRTYLSLLEQSKKDSTLEACAGALQNLT 582

  Fly   552 ACYWQPSIDIRATV-RKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLV 615
            |...|.|..:...: .|:||:|.:..||:.....||.|.::.|.|::......:.:...|:.|:.
Frog   583 ASKGQMSNGMSQIIGLKDKGIPQITRLLQSGNADVVKAGSSLLSNMSRHPSLHKTMATQALPDVS 647

  Fly   616 QKL--PSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCV 678
            :.|  .||...:    |:|.:::...|:..:....|:.::..:....:..|:|:.|   ...|..
Frog   648 RILSQSSGKTMN----SEDILSSACYTMRNLAMAEPQIAKQNISGNLLGNLVNMCK---SGASPK 705

  Fly   679 LKFASQVLYT-MWQHNELRDVYKKNGWKEQDFVSKHFTA-HNTPP 721
            :..|::|..| ||...||:...|:.|..:....|...|| .||.|
Frog   706 VGEAARVFLTDMWAQRELQGFLKQQGLDKSIMGSLASTALRNTIP 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	35/113 (31%)
		armadillo repeat	227..252	CDD:293788	6/24 (25%)
		armadillo repeat	260..296	CDD:293788	12/35 (34%)
		armadillo repeat	304..339	CDD:293788	11/34 (32%)
		ARM	307..442	CDD:237987	51/137 (37%)
		armadillo repeat	347..392	CDD:293788	16/47 (34%)
		armadillo repeat	515..556	CDD:293788	17/40 (43%)
		ARM	516..643	CDD:237987	38/129 (29%)
		armadillo repeat	562..596	CDD:293788	10/34 (29%)
		armadillo repeat	601..641	CDD:293788	7/41 (17%)
pkp1	XP_012809816.1	armadillo repeat	273..298	CDD:293788	6/24 (25%)
		Syo1_like	301..>506	CDD:240521	73/210 (35%)
		ARM	302..342	CDD:214547	13/39 (33%)
		armadillo repeat	306..342	CDD:293788	12/35 (34%)
		armadillo repeat	348..383	CDD:293788	11/34 (32%)
		armadillo repeat	391..439	CDD:293788	16/47 (34%)
		Arm	542..582	CDD:366143	17/50 (34%)
		armadillo repeat	555..581	CDD:293788	13/25 (52%)
		armadillo repeat	595..630	CDD:293788	11/34 (32%)
		armadillo repeat	636..674	CDD:293788	8/41 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100