DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and ARHGAP32

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001364953.1	Gene:	ARHGAP32 / 9743	HGNCID:	17399	Length:	2101	Species:	Homo sapiens

Alignment Length:	296	Identity:	65/296 - (21%)
Similarity:	117/296 - (39%)	Gaps:	45/296 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 KRKPFKRRRKEEG----NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLR 402
            |.:|.|::.|:.|    .:||..:...:..    :|.:   ||..|:.....:.|.|. .:|:.|
Human   365 KSRPTKQKLKQRGILKERVFGCDLGEHLLN----SGFE---VPQVLQSCTAFIERYGI-VDGIYR 421

  Fly   403 IGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQC 467
            :.|.....:.|.:|.:|...  ||.....: ...:|.:.||.|.:.||||.||||.:|.:.|...
Human   422 LSGVASNIQRLRHEFDSEHV--PDLTKEPY-VQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 483

  Fly   468 HTLPSIDQMNALSI--LCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR 530
             ...:.|:...:.|  :...|||.:..||..|:...:::.:...|..|:..|:|.:.||::...:
Human   484 -VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSK 547

  Fly   531 YIHPSDNNSIAEQVRMAAQCCRLTNIL--------------ILRGEKLFQVPNNLIVESQKTMMG 581
            .|..:..:..|..:.:..|...:..||              :..|......|.:|:|.|..|.:
Human   548 QIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKL- 611

  Fly   582 KKGWHRHRNSNEITAKPSGKASNVGVGHDSTVINKY 617
                        :|.:.:...:...|.......|||
Human   612 ------------LTLEEAQARTQAQVNSPIVTENKY 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	53/235 (23%)
ARHGAP32	NP_001364953.1	PX_RICS	141..255	CDD:132831
		SH3_ARHGAP32_33	277..330	CDD:212769
		RhoGAP_CdGAP	382..576	CDD:239849	49/205 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..872
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..1052
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1183..1271
		Interaction with GAB2. /evidence=ECO:0000269\|PubMed:12819203	1405..1725
		Interaction with FYN. /evidence=ECO:0000269\|PubMed:12788081	1699..2101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1812..1910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910