DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and ARHGAP22

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_011538304.1	Gene:	ARHGAP22 / 58504	HGNCID:	30320	Length:	720	Species:	Homo sapiens

Alignment Length:	313	Identity:	79/313 - (25%)
Similarity:	135/313 - (43%)	Gaps:	56/313 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 SETDM----KRLQTILWLEL--ATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVT 372
            |:.||    :.::.::|..|  .|....:...|:...|         .:||..:...:..:::.
Human   135 SQRDMEDWVQAIRRVIWAPLGGGTARRSHAHPLEPLPP---------GIFGQRLEETVHHERKY- 189

  Fly   373 GTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTF--YQNPDNLDNLFRTA 435
              ...|.||.:|:.:..:..||..||||.|:.|...    |..:|:.:|  .:.|     ||.:.
Human   190 --GPRLAPLLVEQCVDFIRERGLTEEGLFRMPGQAN----LVRDLQDSFDCGEKP-----LFDST 243

  Fly   436 T-VHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNA---LSILCHLLPPENRNTLRS 496
            | ||.::||||.:|||||:|::.....:.|..|..|.:.|:...   |:.....||..|.|.||.
Human   244 TDVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRY 308

  Fly   497 LLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHP---SDNNSIAEQVRMAAQCCRLTNILI 558
            :..|.:.:....::|||:|.|:||:..|::..|:...|   .:..|:.:         .|..:||
Human   309 ICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLVQ---------HLMTVLI 364

  Fly   559 LRGEKLFQVPNNLIVESQKTMMG----KKGWHRHRNSNEITAKPSGKASNVGV 607
            .:..:||..|   :.|...:..|    ..||    .|.|:|....|:....|:
Human   365 RKHSQLFTAP---VPEGPTSPRGGLQCAVGW----GSEEVTRDSQGEPGGPGL 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	63/228 (28%)
ARHGAP22	XP_011538304.1	PH_RhoGAP2	42..157	CDD:241529	5/21 (24%)
		RhoGAP_ARHGAP22_24_25	173..371	CDD:239855	59/218 (27%)
		SMC_N	<612..>700	CDD:330553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910